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Article: Impact of Right Ventricular Dilation on Left Ventricular Myocardial Deformation in Patients After Surgical Repair of Tetralogy of Fallot

TitleImpact of Right Ventricular Dilation on Left Ventricular Myocardial Deformation in Patients After Surgical Repair of Tetralogy of Fallot
Authors
Issue Date2009
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 2009, v. 104 n. 9, p. 1264-1270 How to Cite?
AbstractLeft ventricular (LV) dysfunction is 1 of the major determinants of late adverse clinical outcomes in patients after surgical repair of tetralogy of Fallot (TOF). The aim of this study was to test the hypothesis that LV myocardial deformation is impaired in patients after TOF repair and related to right ventricular (RV) dilation and exercise capacity. Longitudinal, radial, and circumferential LV myocardial deformation was determined using speckle-tracking echocardiography in 23 postoperative patients with TOF and compared to that of 23 age-matched controls. Relations between LV strain and strain rate (SR) and RV volumes and exercise parameters were determined in patients. Compared to controls, patients had reduced global LV longitudinal, radial, and circumferential strain (all p values <0.05). Patients with significantly increased RV end-systolic volume (>2 SDs higher than normal; n = 17) had reduced global LV circumferential strain (p = 0.048) and SR (p = 0.038), but similar longitudinal and radial speckle-tracking echocardiographic parameters, compared to those without (n = 6). RV end-systolic volume was correlated inversely with global LV circumferential strain and SR (r = -0.58, p = 0.004, and r = -0.58, p = 0.005, respectively), while RV end-diastolic volume was correlated only with global LV circumferential strain (r = -0.43, p = 0.047). In patients, the LV ejection fraction was correlated with global LV circumferential strain (r = 0.54, p = 0.01) and SR (r = 0.66, p = 0.001) but not with longitudinal or radial speckle-tracking echocardiographic parameters. Using multivariate analysis, global LV circumferential SR (β = 0.66, p = 0.001) and male gender (β = 0.46, p = 0.012) were identified as independent predictors of peak oxygen consumption. In conclusion, the negative impact of RV dilation on LV function relates to its influence on LV circumferential strain and SR in patients after TOF repair. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170427
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, EWYen_US
dc.contributor.authorLiang, Xcen_US
dc.contributor.authorLam, WWMen_US
dc.contributor.authorCheung, Yfen_US
dc.date.accessioned2012-10-30T06:08:28Z-
dc.date.available2012-10-30T06:08:28Z-
dc.date.issued2009en_US
dc.identifier.citationAmerican Journal Of Cardiology, 2009, v. 104 n. 9, p. 1264-1270en_US
dc.identifier.issn0002-9149en_US
dc.identifier.urihttp://hdl.handle.net/10722/170427-
dc.description.abstractLeft ventricular (LV) dysfunction is 1 of the major determinants of late adverse clinical outcomes in patients after surgical repair of tetralogy of Fallot (TOF). The aim of this study was to test the hypothesis that LV myocardial deformation is impaired in patients after TOF repair and related to right ventricular (RV) dilation and exercise capacity. Longitudinal, radial, and circumferential LV myocardial deformation was determined using speckle-tracking echocardiography in 23 postoperative patients with TOF and compared to that of 23 age-matched controls. Relations between LV strain and strain rate (SR) and RV volumes and exercise parameters were determined in patients. Compared to controls, patients had reduced global LV longitudinal, radial, and circumferential strain (all p values <0.05). Patients with significantly increased RV end-systolic volume (>2 SDs higher than normal; n = 17) had reduced global LV circumferential strain (p = 0.048) and SR (p = 0.038), but similar longitudinal and radial speckle-tracking echocardiographic parameters, compared to those without (n = 6). RV end-systolic volume was correlated inversely with global LV circumferential strain and SR (r = -0.58, p = 0.004, and r = -0.58, p = 0.005, respectively), while RV end-diastolic volume was correlated only with global LV circumferential strain (r = -0.43, p = 0.047). In patients, the LV ejection fraction was correlated with global LV circumferential strain (r = 0.54, p = 0.01) and SR (r = 0.66, p = 0.001) but not with longitudinal or radial speckle-tracking echocardiographic parameters. Using multivariate analysis, global LV circumferential SR (β = 0.66, p = 0.001) and male gender (β = 0.46, p = 0.012) were identified as independent predictors of peak oxygen consumption. In conclusion, the negative impact of RV dilation on LV function relates to its influence on LV circumferential strain and SR in patients after TOF repair. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshEchocardiography - Methodsen_US
dc.subject.meshExercise Testen_US
dc.subject.meshExercise Tolerance - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Ventricles - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertrophy, Right Ventricular - Physiopathologyen_US
dc.subject.meshMagnetic Resonance Imaging, Cineen_US
dc.subject.meshMaleen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshStroke Volume - Physiologyen_US
dc.subject.meshSystole - Physiologyen_US
dc.subject.meshTetralogy Of Fallot - Physiopathology - Surgeryen_US
dc.subject.meshVentricular Dysfunction, Left - Pathology - Physiopathologyen_US
dc.titleImpact of Right Ventricular Dilation on Left Ventricular Myocardial Deformation in Patients After Surgical Repair of Tetralogy of Falloten_US
dc.typeArticleen_US
dc.identifier.emailCheung, Yf:xfcheung@hku.hken_US
dc.identifier.authorityCheung, Yf=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.amjcard.2009.06.043en_US
dc.identifier.pmid19840574-
dc.identifier.scopuseid_2-s2.0-72049111269en_US
dc.identifier.hkuros160066-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-72049111269&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume104en_US
dc.identifier.issue9en_US
dc.identifier.spage1264en_US
dc.identifier.epage1270en_US
dc.identifier.isiWOS:000271487100019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, EWY=9432819700en_US
dc.identifier.scopusauthoridLiang, Xc=12803290200en_US
dc.identifier.scopusauthoridLam, WWM=35292558200en_US
dc.identifier.scopusauthoridCheung, Yf=7202111067en_US
dc.identifier.citeulike5977439-

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