Article: Functional implications of the right ventricular myocardial performance index in patients after surgical repair of tetralogy of Fallot

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TitleFunctional implications of the right ventricular myocardial performance index in patients after surgical repair of tetralogy of Fallot
AuthorsCheung, EWY1
Lam, WWM2
Cheung, SCW2
Cheung, YF1
Issue Date2008
PublisherSpringer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327
CitationHeart And Vessels, 2008, v. 23 n. 2, p. 112-117 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00380-007-1016-7
AbstractThe myocardial performance index (MPI) has been proposed to be a simple echocardiographic index of right ventricular (RV) function in patients after surgical repair of tetralogy of Fallot (TOF). However, its functional status remains to be clarified. The functional implications of RV MPI were determined by exploring its relationships with parameters of RV function as derived from cardiovascular magnetic resonance (CMR), and exercise capacity of postoperative TOF patients Thirty patients (11 males), aged 15.6 3.1 years, who have undergone surgical repair of TOF at 4.0 1.8 years, were studied. The RV and left ventricular (LV) MPIs determined using pulsed-wave Doppler echocardiography were related to CMR-derived RV and LV ejection fractions, and pulmonary regurgitant fraction and treadmill exercise testing parameters. Log RV MPI correlated positively with log LV MPI (r = 0.38, P = 0.037) and negatively with CMR-derived RV ejection fraction (r = -0.4, P = 0.028) and pulmonary regurgitant fraction (r = -0.4, P = 0.031). No significant correlations were found between LV MPI and any of the CMR parameters. Using receiver operated characteristics analysis, a cutoff value of 0.30 for RV MPI was found to have a sensitivity of 100% and specificity of 74% in predicting a RV ejection fraction <35%. Right ventricular, but not LV, MPI correlated inversely with exercise duration (r = -0.45, P = 0.013) and peak oxygen consumption (VO 2 max) (r = -0.56, P = 0.001). Multivariate analysis identified RV MPI (= -0.6, P < 0.001), male sex (= 0.44, P = 0.01), and duration from surgery (= -0.30, P = 0.019) as significant determinants of VO 2 max. Increased MPI is a reflection of reduced RV ejection fraction and exercise capacity in patients after TOF repair. © Springer Japan 2008.
ISSN0910-8327
2011 Impact Factor: 2.047
2011 SCImago Journal Rankings: 0.130
DOIhttp://dx.doi.org/10.1007/s00380-007-1016-7
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, EWY
dc.contributor.authorLam, WWM
dc.contributor.authorCheung, SCW
dc.contributor.authorCheung, YF
dc.date.accessioned2012-10-30T06:08:00Z
dc.date.available2012-10-30T06:08:00Z
dc.date.issued2008
dc.description.abstractThe myocardial performance index (MPI) has been proposed to be a simple echocardiographic index of right ventricular (RV) function in patients after surgical repair of tetralogy of Fallot (TOF). However, its functional status remains to be clarified. The functional implications of RV MPI were determined by exploring its relationships with parameters of RV function as derived from cardiovascular magnetic resonance (CMR), and exercise capacity of postoperative TOF patients Thirty patients (11 males), aged 15.6 3.1 years, who have undergone surgical repair of TOF at 4.0 1.8 years, were studied. The RV and left ventricular (LV) MPIs determined using pulsed-wave Doppler echocardiography were related to CMR-derived RV and LV ejection fractions, and pulmonary regurgitant fraction and treadmill exercise testing parameters. Log RV MPI correlated positively with log LV MPI (r = 0.38, P = 0.037) and negatively with CMR-derived RV ejection fraction (r = -0.4, P = 0.028) and pulmonary regurgitant fraction (r = -0.4, P = 0.031). No significant correlations were found between LV MPI and any of the CMR parameters. Using receiver operated characteristics analysis, a cutoff value of 0.30 for RV MPI was found to have a sensitivity of 100% and specificity of 74% in predicting a RV ejection fraction <35%. Right ventricular, but not LV, MPI correlated inversely with exercise duration (r = -0.45, P = 0.013) and peak oxygen consumption (VO 2 max) (r = -0.56, P = 0.001). Multivariate analysis identified RV MPI (= -0.6, P < 0.001), male sex (= 0.44, P = 0.01), and duration from surgery (= -0.30, P = 0.019) as significant determinants of VO 2 max. Increased MPI is a reflection of reduced RV ejection fraction and exercise capacity in patients after TOF repair. © Springer Japan 2008.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHeart And Vessels, 2008, v. 23 n. 2, p. 112-117 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00380-007-1016-7
dc.identifier.doihttp://dx.doi.org/10.1007/s00380-007-1016-7
dc.identifier.epage117
dc.identifier.issn0910-8327
2011 Impact Factor: 2.047
2011 SCImago Journal Rankings: 0.130
dc.identifier.issue2
dc.identifier.pmid18389336
dc.identifier.scopuseid_2-s2.0-41849141595
dc.identifier.spage112
dc.identifier.urihttp://hdl.handle.net/10722/170395
dc.identifier.volume23
dc.languageeng
dc.publisherSpringer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327
dc.publisher.placeJapan
dc.relation.ispartofHeart and Vessels
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshCardiac Surgical Procedures
dc.subject.meshChild
dc.subject.meshEchocardiography, Doppler, Pulsed
dc.subject.meshExercise Test
dc.subject.meshExercise Tolerance
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging, Cine
dc.subject.meshMale
dc.subject.meshPredictive Value Of Tests
dc.subject.meshPulmonary Circulation
dc.subject.meshRoc Curve
dc.subject.meshSensitivity And Specificity
dc.subject.meshStroke Volume
dc.subject.meshTetralogy Of Fallot - Pathology - Physiopathology - Surgery
dc.subject.meshTreatment Outcome
dc.subject.meshVentricular Function, Left
dc.subject.meshVentricular Function, Right
dc.subject.meshYoung Adult
dc.titleFunctional implications of the right ventricular myocardial performance index in patients after surgical repair of tetralogy of Fallot
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong