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Article: Functional implications of the right ventricular myocardial performance index in patients after surgical repair of tetralogy of Fallot
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TitleFunctional implications of the right ventricular myocardial performance index in patients after surgical repair of tetralogy of Fallot
 
AuthorsCheung, EWY1
Lam, WWM2
Cheung, SCW2
Cheung, YF1
 
Issue Date2008
 
PublisherSpringer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327
 
CitationHeart And Vessels, 2008, v. 23 n. 2, p. 112-117 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00380-007-1016-7
 
AbstractThe myocardial performance index (MPI) has been proposed to be a simple echocardiographic index of right ventricular (RV) function in patients after surgical repair of tetralogy of Fallot (TOF). However, its functional status remains to be clarified. The functional implications of RV MPI were determined by exploring its relationships with parameters of RV function as derived from cardiovascular magnetic resonance (CMR), and exercise capacity of postoperative TOF patients Thirty patients (11 males), aged 15.6 3.1 years, who have undergone surgical repair of TOF at 4.0 1.8 years, were studied. The RV and left ventricular (LV) MPIs determined using pulsed-wave Doppler echocardiography were related to CMR-derived RV and LV ejection fractions, and pulmonary regurgitant fraction and treadmill exercise testing parameters. Log RV MPI correlated positively with log LV MPI (r = 0.38, P = 0.037) and negatively with CMR-derived RV ejection fraction (r = -0.4, P = 0.028) and pulmonary regurgitant fraction (r = -0.4, P = 0.031). No significant correlations were found between LV MPI and any of the CMR parameters. Using receiver operated characteristics analysis, a cutoff value of 0.30 for RV MPI was found to have a sensitivity of 100% and specificity of 74% in predicting a RV ejection fraction <35%. Right ventricular, but not LV, MPI correlated inversely with exercise duration (r = -0.45, P = 0.013) and peak oxygen consumption (VO 2 max) (r = -0.56, P = 0.001). Multivariate analysis identified RV MPI (= -0.6, P < 0.001), male sex (= 0.44, P = 0.01), and duration from surgery (= -0.30, P = 0.019) as significant determinants of VO 2 max. Increased MPI is a reflection of reduced RV ejection fraction and exercise capacity in patients after TOF repair. © Springer Japan 2008.
 
ISSN0910-8327
2012 Impact Factor: 2.126
2012 SCImago Journal Rankings: 0.658
 
DOIhttp://dx.doi.org/10.1007/s00380-007-1016-7
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, EWY
 
dc.contributor.authorLam, WWM
 
dc.contributor.authorCheung, SCW
 
dc.contributor.authorCheung, YF
 
dc.date.accessioned2012-10-30T06:08:00Z
 
dc.date.available2012-10-30T06:08:00Z
 
dc.date.issued2008
 
dc.description.abstractThe myocardial performance index (MPI) has been proposed to be a simple echocardiographic index of right ventricular (RV) function in patients after surgical repair of tetralogy of Fallot (TOF). However, its functional status remains to be clarified. The functional implications of RV MPI were determined by exploring its relationships with parameters of RV function as derived from cardiovascular magnetic resonance (CMR), and exercise capacity of postoperative TOF patients Thirty patients (11 males), aged 15.6 3.1 years, who have undergone surgical repair of TOF at 4.0 1.8 years, were studied. The RV and left ventricular (LV) MPIs determined using pulsed-wave Doppler echocardiography were related to CMR-derived RV and LV ejection fractions, and pulmonary regurgitant fraction and treadmill exercise testing parameters. Log RV MPI correlated positively with log LV MPI (r = 0.38, P = 0.037) and negatively with CMR-derived RV ejection fraction (r = -0.4, P = 0.028) and pulmonary regurgitant fraction (r = -0.4, P = 0.031). No significant correlations were found between LV MPI and any of the CMR parameters. Using receiver operated characteristics analysis, a cutoff value of 0.30 for RV MPI was found to have a sensitivity of 100% and specificity of 74% in predicting a RV ejection fraction <35%. Right ventricular, but not LV, MPI correlated inversely with exercise duration (r = -0.45, P = 0.013) and peak oxygen consumption (VO 2 max) (r = -0.56, P = 0.001). Multivariate analysis identified RV MPI (= -0.6, P < 0.001), male sex (= 0.44, P = 0.01), and duration from surgery (= -0.30, P = 0.019) as significant determinants of VO 2 max. Increased MPI is a reflection of reduced RV ejection fraction and exercise capacity in patients after TOF repair. © Springer Japan 2008.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHeart And Vessels, 2008, v. 23 n. 2, p. 112-117 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00380-007-1016-7
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00380-007-1016-7
 
dc.identifier.epage117
 
dc.identifier.issn0910-8327
2012 Impact Factor: 2.126
2012 SCImago Journal Rankings: 0.658
 
dc.identifier.issue2
 
dc.identifier.pmid18389336
 
dc.identifier.scopuseid_2-s2.0-41849141595
 
dc.identifier.spage112
 
dc.identifier.urihttp://hdl.handle.net/10722/170395
 
dc.identifier.volume23
 
dc.languageeng
 
dc.publisherSpringer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327
 
dc.publisher.placeJapan
 
dc.relation.ispartofHeart and Vessels
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshCardiac Surgical Procedures
 
dc.subject.meshChild
 
dc.subject.meshEchocardiography, Doppler, Pulsed
 
dc.subject.meshExercise Test
 
dc.subject.meshExercise Tolerance
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMagnetic Resonance Imaging, Cine
 
dc.subject.meshMale
 
dc.subject.meshPredictive Value Of Tests
 
dc.subject.meshPulmonary Circulation
 
dc.subject.meshRoc Curve
 
dc.subject.meshSensitivity And Specificity
 
dc.subject.meshStroke Volume
 
dc.subject.meshTetralogy Of Fallot - Pathology - Physiopathology - Surgery
 
dc.subject.meshTreatment Outcome
 
dc.subject.meshVentricular Function, Left
 
dc.subject.meshVentricular Function, Right
 
dc.subject.meshYoung Adult
 
dc.titleFunctional implications of the right ventricular myocardial performance index in patients after surgical repair of tetralogy of Fallot
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong