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Article: Plasma brain natriuretic peptide and systemic ventricular function in asymptomatic patients late after the Fontan procedure

TitlePlasma brain natriuretic peptide and systemic ventricular function in asymptomatic patients late after the Fontan procedure
Authors
Issue Date2007
PublisherSpringer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327
Citation
Heart And Vessels, 2007, v. 22 n. 6, p. 398-403 How to Cite?
AbstractWhile increased plasma brain natriuretic peptide (BNP) levels have been documented late after the Fontan procedure, its significance remains unclear. We sought to test the hypothesis that plasma BNP levels reflect systemic ventricular function after the Fontan procedure by interrogating the relationship between plasma BNP level and indices of ventricular function. The plasma BNP levels and systemic ventricular function, as determined by conventional and tissue Doppler assessments, acoustic quantification (AQ), and myocardial performance index (MPI), of 35 asymptomatic Fontan patients were compared to those of 34 control subjects who had previous repair of ventricular septal defect. When compared with controls, Fontan patients had significantly higher plasma BNP levels (median 21pg/ml, range 5-397 vs median 15pg/ml, range 5-62, P = 0.04). Their systolic and diastolic ventricular function was impaired as evidenced by reduced systemic ventricular early diastolic (E) inflow velocity, early to late (A) diastolic inflow velocity ratio, left and right annular early diastolic (e), late diastolic (a), and systolic (s) velocities, AQ-derived ventricular fractional area change, peak emptying rate, and peak filling rate, and increased AQ-derived atrial filling fraction and MPI (all P < 0.05). Plasma BNP levels correlated negatively with E and A velocities, left-sided annular a velocity, and right-sided annular e, a, and s velocities, and positively with AQ-derived atrial filling fraction (all P < 0.05). In conclusion, our findings suggest that plasma BNP levels reflect primarily the diastolic function of the systemic ventricle in asymptomatic Fontan patients. © Springer-Verlag Tokyo 2007.
Persistent Identifierhttp://hdl.handle.net/10722/170390
ISSN
2015 Impact Factor: 2.293
2015 SCImago Journal Rankings: 0.709
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMan, BLen_US
dc.contributor.authorCheung, YFen_US
dc.date.accessioned2012-10-30T06:07:58Z-
dc.date.available2012-10-30T06:07:58Z-
dc.date.issued2007en_US
dc.identifier.citationHeart And Vessels, 2007, v. 22 n. 6, p. 398-403en_US
dc.identifier.issn0910-8327en_US
dc.identifier.urihttp://hdl.handle.net/10722/170390-
dc.description.abstractWhile increased plasma brain natriuretic peptide (BNP) levels have been documented late after the Fontan procedure, its significance remains unclear. We sought to test the hypothesis that plasma BNP levels reflect systemic ventricular function after the Fontan procedure by interrogating the relationship between plasma BNP level and indices of ventricular function. The plasma BNP levels and systemic ventricular function, as determined by conventional and tissue Doppler assessments, acoustic quantification (AQ), and myocardial performance index (MPI), of 35 asymptomatic Fontan patients were compared to those of 34 control subjects who had previous repair of ventricular septal defect. When compared with controls, Fontan patients had significantly higher plasma BNP levels (median 21pg/ml, range 5-397 vs median 15pg/ml, range 5-62, P = 0.04). Their systolic and diastolic ventricular function was impaired as evidenced by reduced systemic ventricular early diastolic (E) inflow velocity, early to late (A) diastolic inflow velocity ratio, left and right annular early diastolic (e), late diastolic (a), and systolic (s) velocities, AQ-derived ventricular fractional area change, peak emptying rate, and peak filling rate, and increased AQ-derived atrial filling fraction and MPI (all P < 0.05). Plasma BNP levels correlated negatively with E and A velocities, left-sided annular a velocity, and right-sided annular e, a, and s velocities, and positively with AQ-derived atrial filling fraction (all P < 0.05). In conclusion, our findings suggest that plasma BNP levels reflect primarily the diastolic function of the systemic ventricle in asymptomatic Fontan patients. © Springer-Verlag Tokyo 2007.en_US
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327en_US
dc.relation.ispartofHeart and Vesselsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshEchocardiography, Doppleren_US
dc.subject.meshFemaleen_US
dc.subject.meshFontan Procedure - Adverse Effectsen_US
dc.subject.meshHeart Failure, Diastolic - Ultrasonographyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNatriuretic Peptide, Brain - Blooden_US
dc.subject.meshVentricular Dysfunction, Left - Blood - Etiology - Ultrasonographyen_US
dc.subject.meshVentricular Function, Leften_US
dc.titlePlasma brain natriuretic peptide and systemic ventricular function in asymptomatic patients late after the Fontan procedureen_US
dc.typeArticleen_US
dc.identifier.emailCheung, YF:xfcheung@hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00380-007-0993-xen_US
dc.identifier.pmid18043998-
dc.identifier.scopuseid_2-s2.0-36749075699en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36749075699&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue6en_US
dc.identifier.spage398en_US
dc.identifier.epage403en_US
dc.identifier.isiWOS:000251235900008-
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridMan, BL=36770209000en_US
dc.identifier.scopusauthoridCheung, YF=7202111067en_US

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