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Article: Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation

TitleRole for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation
Authors
Law, AHYLee, DCWCheung, BKWYim, HCHLau, ASY
Issue Date2007
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2007, v. 81 n. 1, p. 416-422 How to Cite?
DOI: http://dx.doi.org/10.1128/JVI.02336-05
AbstractSevere acute respiratory syndrome (SARS) is an emerging infections disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to. immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-κB. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170381
ISSN
0022-538X
2021 Impact Factor: 6.549
2020 SCImago Journal Rankings: 2.617
ISI Accession Number ID
WOS:000242958600039
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLaw, AHYen_US
dc.contributor.authorLee, DCWen_US
dc.contributor.authorCheung, BKWen_US
dc.contributor.authorYim, HCHen_US
dc.contributor.authorLau, ASYen_US
dc.date.accessioned2012-10-30T06:07:55Z-
dc.date.available2012-10-30T06:07:55Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Virology, 2007, v. 81 n. 1, p. 416-422en_US
dc.identifier.issn0022-538Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170381-
dc.description.abstractSevere acute respiratory syndrome (SARS) is an emerging infections disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to. immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-κB. Copyright © 2007, American Society for Microbiology. All Rights Reserved.en_US
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_US
dc.relation.ispartofJournal of Virologyen_US
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.subject.meshChemokine Ccl3en_US
dc.subject.meshChemokine Ccl5en_US
dc.subject.meshChemokine Cxcl10en_US
dc.subject.meshChemokines - Genetics - Metabolismen_US
dc.subject.meshChemokines, Cc - Genetics - Metabolismen_US
dc.subject.meshChemokines, Cxc - Genetics - Metabolismen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshNf-Kappa B - Genetics - Metabolismen_US
dc.subject.meshRespiratory Mucosa - Cytology - Virologyen_US
dc.subject.meshSars Virus - Metabolism - Pathogenicityen_US
dc.subject.meshViral Envelope Proteins - Physiologyen_US
dc.subject.meshViral Matrix Proteins - Physiologyen_US
dc.subject.meshViral Nonstructural Proteins - Metabolismen_US
dc.titleRole for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulationen_US
dc.typeArticleen_US
dc.identifier.emailLau, ASY:asylau@hku.hken_US
dc.identifier.authorityLau, ASY=rp00474en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1128/JVI.02336-05en_US
dc.identifier.pmid17035307-
dc.identifier.scopuseid_2-s2.0-33845775710en_US
dc.identifier.hkuros126297-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845775710&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume81en_US
dc.identifier.issue1en_US
dc.identifier.spage416en_US
dc.identifier.epage422en_US
dc.identifier.isiWOS:000242958600039-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLaw, AHY=8692488400en_US
dc.identifier.scopusauthoridLee, DCW=15751156000en_US
dc.identifier.scopusauthoridCheung, BKW=9634391200en_US
dc.identifier.scopusauthoridYim, HCH=15752404600en_US
dc.identifier.scopusauthoridLau, ASY=7202626202en_US
dc.identifier.issnl0022-538X-

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