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Article: Ethnic differences in coagulation factor abnormalities after the Fontan procedure.

TitleEthnic differences in coagulation factor abnormalities after the Fontan procedure.
Authors
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00246
Citation
Pediatric Cardiology, 2006, v. 27 n. 1, p. 96-101 How to Cite?
AbstractWe tested the hypothesis that Chinese patients have a coagulation profile that is less prothrombotic than that of Caucasian counterparts after the Fontan procedure by determining the type and prevalence of anticoagulant and procoagulant deficiencies in Chinese patients and comparing the findings to those previously reported in Caucasian series. The liver function and coagulation factors were assessed in 21 ethnic Chinese patients, aged 17.0 +/- 5.6 years, at 10.7 +/- 4.0 years after the Fontan procedure. The results were compared to those of 21 age-matched Chinese controls with minor congenital heart disease. The prevalence of coagulation factor deficiencies in our patients was further compared to that reported in Caucasian patients. When compared with controls, patients had significantly lower protein C (p = 0.014), factors II (p = 0.024), V (p < 0.001), VII (p < 0.001), IX (p = 0.036), and X (p < 0.001), and higher bilirubin (p = 0.001) levels. The prevalence of protein C deficiency was 9.5%, whereas those of factor II, V, VII, IX, and X deficiencies were 0, 66.7, 9.5, 0, and 57.1%, respectively. When compared with Caucasian data, our data showed a significantly lower prevalence of protein C, total protein S, antithorombin III, factor II, and factor VII deficiencies. Furthermore, the previously reported increase in factor VIII levels was not found. In contrast, the prevalence of factor X deficiency was higher in our patients. This study provides the first evidence of ethnic differences in coagulation factor abnormalities after the Fontan procedure. The imbalance between procoagulant and anticoagulant pathways in Chinese patients favors a bleeding, rather than a thrombotic, tendency.
Persistent Identifierhttp://hdl.handle.net/10722/170377
ISSN
2015 Impact Factor: 1.452
2015 SCImago Journal Rankings: 0.732
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_US
dc.contributor.authorChay, GWen_US
dc.contributor.authorMa, ESen_US
dc.date.accessioned2012-10-30T06:07:53Z-
dc.date.available2012-10-30T06:07:53Z-
dc.date.issued2006en_US
dc.identifier.citationPediatric Cardiology, 2006, v. 27 n. 1, p. 96-101en_US
dc.identifier.issn0172-0643en_US
dc.identifier.urihttp://hdl.handle.net/10722/170377-
dc.description.abstractWe tested the hypothesis that Chinese patients have a coagulation profile that is less prothrombotic than that of Caucasian counterparts after the Fontan procedure by determining the type and prevalence of anticoagulant and procoagulant deficiencies in Chinese patients and comparing the findings to those previously reported in Caucasian series. The liver function and coagulation factors were assessed in 21 ethnic Chinese patients, aged 17.0 +/- 5.6 years, at 10.7 +/- 4.0 years after the Fontan procedure. The results were compared to those of 21 age-matched Chinese controls with minor congenital heart disease. The prevalence of coagulation factor deficiencies in our patients was further compared to that reported in Caucasian patients. When compared with controls, patients had significantly lower protein C (p = 0.014), factors II (p = 0.024), V (p < 0.001), VII (p < 0.001), IX (p = 0.036), and X (p < 0.001), and higher bilirubin (p = 0.001) levels. The prevalence of protein C deficiency was 9.5%, whereas those of factor II, V, VII, IX, and X deficiencies were 0, 66.7, 9.5, 0, and 57.1%, respectively. When compared with Caucasian data, our data showed a significantly lower prevalence of protein C, total protein S, antithorombin III, factor II, and factor VII deficiencies. Furthermore, the previously reported increase in factor VIII levels was not found. In contrast, the prevalence of factor X deficiency was higher in our patients. This study provides the first evidence of ethnic differences in coagulation factor abnormalities after the Fontan procedure. The imbalance between procoagulant and anticoagulant pathways in Chinese patients favors a bleeding, rather than a thrombotic, tendency.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00246en_US
dc.relation.ispartofPediatric cardiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBlood Coagulation Factors - Analysisen_US
dc.subject.meshChilden_US
dc.subject.meshCoagulation Protein Disorders - Blood - Ethnologyen_US
dc.subject.meshCross-Cultural Comparisonen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshFemaleen_US
dc.subject.meshFontan Procedure - Adverse Effectsen_US
dc.subject.meshHeart Defects, Congenital - Blood - Surgeryen_US
dc.subject.meshHeart Ventricles - Abnormalities - Surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshPostoperative Complications - Blooden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThrombophilia - Blood - Ethnologyen_US
dc.titleEthnic differences in coagulation factor abnormalities after the Fontan procedure.en_US
dc.typeArticleen_US
dc.identifier.emailCheung, YF:xfcheung@hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00246-005-1031-3en_US
dc.identifier.pmid16235018-
dc.identifier.scopuseid_2-s2.0-33748896042en_US
dc.identifier.volume27en_US
dc.identifier.issue1en_US
dc.identifier.spage96en_US
dc.identifier.epage101en_US
dc.identifier.isiWOS:000235575500018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, YF=7202111067en_US
dc.identifier.scopusauthoridChay, GW=9435530600en_US
dc.identifier.scopusauthoridMa, ES=7202039934en_US

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