File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Prevalence of respiratory function abnormalities in asymptomatic Chinese patients with juvenile onset systemic lupus erythematosus
  • Basic View
  • Metadata View
  • XML View
TitlePrevalence of respiratory function abnormalities in asymptomatic Chinese patients with juvenile onset systemic lupus erythematosus
 
AuthorsTsang, HYH1
Lee, SL1
Lee, TL1
Wong, K1
Lau, YL1
 
KeywordsChildren
Chinese
Respiratory Function
Systemic Lupus Erythematosus
 
Issue Date2006
 
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
CitationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 199-204+264 [How to Cite?]
 
AbstractObjectives: To determine the prevalence and features of respiratory function alterations in asymptomatic Chinese patients with juvenile onset systemic erythematosus (JSLE) and to assess its relationship with clinical and immunological parameters. Methods: Twenty-two Chinese patients with JSLE followed up at our Rheumatology Clinic were recruited. Each underwent pulmonary function test (PFT) and completed a respiratory questionnaire. Four were excluded because of past history of pulmonary disease. Abnormal respiratory function findings if present would be correlated with the disease duration, disease activity, organ involvement, clinical features and immunological findings using multiple regression analysis. Results: All 18 patients analysed were totally free of pulmonary symptoms and disease. Thirteen patients (72%) had abnormal PFT results. Ten patients (56%) had decreased diffusion capacity of the lung (DLCO). Among them, 2 had restrictive lung pattern and one had mixed pattern while 7 had isolated DLCO impairment. Disease duration and renal involvement were both found to be significantly associated with decreased DLCO (p=0.037 and p=0.035 respectively). However, both factors became insignificant after multiple regression analysis. Neurological lupus was significantly associated with decreased FEF 25-75% and FEF 75% (p value 0.03 and p<0.001 respectively). Conclusion: Asymptomatic Chinese patients with JSLE and no prior pulmonary involvement showed frequent PFT abnormalities with decreased DLCO being the most common impairment. Neurological involvement was the only factor found to be significantly associated with abnormal lung function parameters. We speculate that decreased DLCO could be related to high occurrence of SLE-associated pulmonary hypertension in Chinese. Further in-depth evaluation and long term follow up study is warranted.
 
ISSN1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTsang, HYH
 
dc.contributor.authorLee, SL
 
dc.contributor.authorLee, TL
 
dc.contributor.authorWong, K
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2012-10-30T06:07:51Z
 
dc.date.available2012-10-30T06:07:51Z
 
dc.date.issued2006
 
dc.description.abstractObjectives: To determine the prevalence and features of respiratory function alterations in asymptomatic Chinese patients with juvenile onset systemic erythematosus (JSLE) and to assess its relationship with clinical and immunological parameters. Methods: Twenty-two Chinese patients with JSLE followed up at our Rheumatology Clinic were recruited. Each underwent pulmonary function test (PFT) and completed a respiratory questionnaire. Four were excluded because of past history of pulmonary disease. Abnormal respiratory function findings if present would be correlated with the disease duration, disease activity, organ involvement, clinical features and immunological findings using multiple regression analysis. Results: All 18 patients analysed were totally free of pulmonary symptoms and disease. Thirteen patients (72%) had abnormal PFT results. Ten patients (56%) had decreased diffusion capacity of the lung (DLCO). Among them, 2 had restrictive lung pattern and one had mixed pattern while 7 had isolated DLCO impairment. Disease duration and renal involvement were both found to be significantly associated with decreased DLCO (p=0.037 and p=0.035 respectively). However, both factors became insignificant after multiple regression analysis. Neurological lupus was significantly associated with decreased FEF 25-75% and FEF 75% (p value 0.03 and p<0.001 respectively). Conclusion: Asymptomatic Chinese patients with JSLE and no prior pulmonary involvement showed frequent PFT abnormalities with decreased DLCO being the most common impairment. Neurological involvement was the only factor found to be significantly associated with abnormal lung function parameters. We speculate that decreased DLCO could be related to high occurrence of SLE-associated pulmonary hypertension in Chinese. Further in-depth evaluation and long term follow up study is warranted.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 199-204+264 [How to Cite?]
 
dc.identifier.epage204+264
 
dc.identifier.hkuros120581
 
dc.identifier.issn1013-9923
2013 Impact Factor: 0.106
2013 SCImago Journal Rankings: 0.126
 
dc.identifier.issue3
 
dc.identifier.scopuseid_2-s2.0-33746349523
 
dc.identifier.spage199
 
dc.identifier.urihttp://hdl.handle.net/10722/170370
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Journal of Paediatrics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectChildren
 
dc.subjectChinese
 
dc.subjectRespiratory Function
 
dc.subjectSystemic Lupus Erythematosus
 
dc.titlePrevalence of respiratory function abnormalities in asymptomatic Chinese patients with juvenile onset systemic lupus erythematosus
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Tsang, HYH</contributor.author>
<contributor.author>Lee, SL</contributor.author>
<contributor.author>Lee, TL</contributor.author>
<contributor.author>Wong, K</contributor.author>
<contributor.author>Lau, YL</contributor.author>
<date.accessioned>2012-10-30T06:07:51Z</date.accessioned>
<date.available>2012-10-30T06:07:51Z</date.available>
<date.issued>2006</date.issued>
<identifier.citation>Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 199-204+264</identifier.citation>
<identifier.issn>1013-9923</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/170370</identifier.uri>
<description.abstract>Objectives: To determine the prevalence and features of respiratory function alterations in asymptomatic Chinese patients with juvenile onset systemic erythematosus (JSLE) and to assess its relationship with clinical and immunological parameters. Methods: Twenty-two Chinese patients with JSLE followed up at our Rheumatology Clinic were recruited. Each underwent pulmonary function test (PFT) and completed a respiratory questionnaire. Four were excluded because of past history of pulmonary disease. Abnormal respiratory function findings if present would be correlated with the disease duration, disease activity, organ involvement, clinical features and immunological findings using multiple regression analysis. Results: All 18 patients analysed were totally free of pulmonary symptoms and disease. Thirteen patients (72%) had abnormal PFT results. Ten patients (56%) had decreased diffusion capacity of the lung (DLCO). Among them, 2 had restrictive lung pattern and one had mixed pattern while 7 had isolated DLCO impairment. Disease duration and renal involvement were both found to be significantly associated with decreased DLCO (p=0.037 and p=0.035 respectively). However, both factors became insignificant after multiple regression analysis. Neurological lupus was significantly associated with decreased FEF 25-75% and FEF 75% (p value 0.03 and p&lt;0.001 respectively). Conclusion: Asymptomatic Chinese patients with JSLE and no prior pulmonary involvement showed frequent PFT abnormalities with decreased DLCO being the most common impairment. Neurological involvement was the only factor found to be significantly associated with abnormal lung function parameters. We speculate that decreased DLCO could be related to high occurrence of SLE-associated pulmonary hypertension in Chinese. Further in-depth evaluation and long term follow up study is warranted.</description.abstract>
<language>eng</language>
<publisher>Medcom Limited. The Journal&apos;s web site is located at http://www.hkjpaed.org/index.asp</publisher>
<relation.ispartof>Hong Kong Journal of Paediatrics</relation.ispartof>
<subject>Children</subject>
<subject>Chinese</subject>
<subject>Respiratory Function</subject>
<subject>Systemic Lupus Erythematosus</subject>
<title>Prevalence of respiratory function abnormalities in asymptomatic Chinese patients with juvenile onset systemic lupus erythematosus</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.scopus>eid_2-s2.0-33746349523</identifier.scopus>
<identifier.hkuros>120581</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-33746349523&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>11</identifier.volume>
<identifier.issue>3</identifier.issue>
<identifier.spage>199</identifier.spage>
<identifier.epage>204+264</identifier.epage>
<publisher.place>Hong Kong</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong