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Article: Prevalence of respiratory function abnormalities in asymptomatic Chinese patients with juvenile onset systemic lupus erythematosus

TitlePrevalence of respiratory function abnormalities in asymptomatic Chinese patients with juvenile onset systemic lupus erythematosus
Authors
KeywordsChildren
Chinese
Respiratory Function
Systemic Lupus Erythematosus
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 199-204+264 How to Cite?
AbstractObjectives: To determine the prevalence and features of respiratory function alterations in asymptomatic Chinese patients with juvenile onset systemic erythematosus (JSLE) and to assess its relationship with clinical and immunological parameters. Methods: Twenty-two Chinese patients with JSLE followed up at our Rheumatology Clinic were recruited. Each underwent pulmonary function test (PFT) and completed a respiratory questionnaire. Four were excluded because of past history of pulmonary disease. Abnormal respiratory function findings if present would be correlated with the disease duration, disease activity, organ involvement, clinical features and immunological findings using multiple regression analysis. Results: All 18 patients analysed were totally free of pulmonary symptoms and disease. Thirteen patients (72%) had abnormal PFT results. Ten patients (56%) had decreased diffusion capacity of the lung (DLCO). Among them, 2 had restrictive lung pattern and one had mixed pattern while 7 had isolated DLCO impairment. Disease duration and renal involvement were both found to be significantly associated with decreased DLCO (p=0.037 and p=0.035 respectively). However, both factors became insignificant after multiple regression analysis. Neurological lupus was significantly associated with decreased FEF 25-75% and FEF 75% (p value 0.03 and p<0.001 respectively). Conclusion: Asymptomatic Chinese patients with JSLE and no prior pulmonary involvement showed frequent PFT abnormalities with decreased DLCO being the most common impairment. Neurological involvement was the only factor found to be significantly associated with abnormal lung function parameters. We speculate that decreased DLCO could be related to high occurrence of SLE-associated pulmonary hypertension in Chinese. Further in-depth evaluation and long term follow up study is warranted.
Persistent Identifierhttp://hdl.handle.net/10722/170370
ISSN
2014 Impact Factor: 0.133
2014 SCImago Journal Rankings: 0.126
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, HYHen_US
dc.contributor.authorLee, SLen_US
dc.contributor.authorLee, TLen_US
dc.contributor.authorWong, Ken_US
dc.contributor.authorLau, YLen_US
dc.date.accessioned2012-10-30T06:07:51Z-
dc.date.available2012-10-30T06:07:51Z-
dc.date.issued2006en_US
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 199-204+264en_US
dc.identifier.issn1013-9923en_US
dc.identifier.urihttp://hdl.handle.net/10722/170370-
dc.description.abstractObjectives: To determine the prevalence and features of respiratory function alterations in asymptomatic Chinese patients with juvenile onset systemic erythematosus (JSLE) and to assess its relationship with clinical and immunological parameters. Methods: Twenty-two Chinese patients with JSLE followed up at our Rheumatology Clinic were recruited. Each underwent pulmonary function test (PFT) and completed a respiratory questionnaire. Four were excluded because of past history of pulmonary disease. Abnormal respiratory function findings if present would be correlated with the disease duration, disease activity, organ involvement, clinical features and immunological findings using multiple regression analysis. Results: All 18 patients analysed were totally free of pulmonary symptoms and disease. Thirteen patients (72%) had abnormal PFT results. Ten patients (56%) had decreased diffusion capacity of the lung (DLCO). Among them, 2 had restrictive lung pattern and one had mixed pattern while 7 had isolated DLCO impairment. Disease duration and renal involvement were both found to be significantly associated with decreased DLCO (p=0.037 and p=0.035 respectively). However, both factors became insignificant after multiple regression analysis. Neurological lupus was significantly associated with decreased FEF 25-75% and FEF 75% (p value 0.03 and p<0.001 respectively). Conclusion: Asymptomatic Chinese patients with JSLE and no prior pulmonary involvement showed frequent PFT abnormalities with decreased DLCO being the most common impairment. Neurological involvement was the only factor found to be significantly associated with abnormal lung function parameters. We speculate that decreased DLCO could be related to high occurrence of SLE-associated pulmonary hypertension in Chinese. Further in-depth evaluation and long term follow up study is warranted.en_US
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_US
dc.relation.ispartofHong Kong Journal of Paediatricsen_US
dc.subjectChildrenen_US
dc.subjectChineseen_US
dc.subjectRespiratory Functionen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.titlePrevalence of respiratory function abnormalities in asymptomatic Chinese patients with juvenile onset systemic lupus erythematosusen_US
dc.typeArticleen_US
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33746349523en_US
dc.identifier.hkuros120581-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746349523&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue3en_US
dc.identifier.spage199en_US
dc.identifier.epage204+264en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridTsang, HYH=7006768516en_US
dc.identifier.scopusauthoridLee, SL=8708381600en_US
dc.identifier.scopusauthoridLee, TL=24483772800en_US
dc.identifier.scopusauthoridWong, K=36485841700en_US
dc.identifier.scopusauthoridLau, YL=7201403380en_US

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