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Article: Successful treatment of X-linked lymphoproliferative disease (XLP) with anti-CD20 monoclonal antibody (Rituximab) followed by mismatched unrelated cord blood transplantation

TitleSuccessful treatment of X-linked lymphoproliferative disease (XLP) with anti-CD20 monoclonal antibody (Rituximab) followed by mismatched unrelated cord blood transplantation
Authors
KeywordsAnti-Cd20 Monoclonal Antibody
Cord Blood Transplantation
Rituximab
X-Linked Lymphoproliferative Disease
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 210-214+264 How to Cite?
AbstractA 4-year-old boy with X-linked lymphoproliferative disease (XLP) developed life-threatening acute lymphoproliferative crisis and failed to respond to conventional treatment of dexamethasone and etoposide. With the knowledge that uncontrolled alloreactive cytotoxic T-cell responses triggered by EBV-transformed B cells is the main cause of XLP, anti-CD20 monoclonocal antibody (Rituximab) which directed against B lymphocytes was use to damp down the patient's dysregulated immune response. He responded well to this novel approach and entered into complete remission with this treatment. His inherited immuno-deficient genetic defect was subsequently corrected by unrelated cord blood transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/170368
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorLee, TLen_US
dc.contributor.authorLaw, HKWen_US
dc.contributor.authorChan, GCFen_US
dc.contributor.authorHa, SYen_US
dc.contributor.authorHo, MHKen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorLau, YLen_US
dc.date.accessioned2012-10-30T06:07:51Z-
dc.date.available2012-10-30T06:07:51Z-
dc.date.issued2006en_US
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 3, p. 210-214+264en_US
dc.identifier.issn1013-9923en_US
dc.identifier.urihttp://hdl.handle.net/10722/170368-
dc.description.abstractA 4-year-old boy with X-linked lymphoproliferative disease (XLP) developed life-threatening acute lymphoproliferative crisis and failed to respond to conventional treatment of dexamethasone and etoposide. With the knowledge that uncontrolled alloreactive cytotoxic T-cell responses triggered by EBV-transformed B cells is the main cause of XLP, anti-CD20 monoclonocal antibody (Rituximab) which directed against B lymphocytes was use to damp down the patient's dysregulated immune response. He responded well to this novel approach and entered into complete remission with this treatment. His inherited immuno-deficient genetic defect was subsequently corrected by unrelated cord blood transplantation.en_US
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_US
dc.relation.ispartofHong Kong Journal of Paediatricsen_US
dc.subjectAnti-Cd20 Monoclonal Antibodyen_US
dc.subjectCord Blood Transplantationen_US
dc.subjectRituximaben_US
dc.subjectX-Linked Lymphoproliferative Diseaseen_US
dc.titleSuccessful treatment of X-linked lymphoproliferative disease (XLP) with anti-CD20 monoclonal antibody (Rituximab) followed by mismatched unrelated cord blood transplantationen_US
dc.typeArticleen_US
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_US
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33746331029en_US
dc.identifier.hkuros120575-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746331029&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue3en_US
dc.identifier.spage210en_US
dc.identifier.epage214+264en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridLee, TL=24483772800en_US
dc.identifier.scopusauthoridLaw, HKW=7101939394en_US
dc.identifier.scopusauthoridChan, GCF=16160154400en_US
dc.identifier.scopusauthoridHa, SY=7202501115en_US
dc.identifier.scopusauthoridHo, MHK=36554116300en_US
dc.identifier.scopusauthoridChan, KW=8587755300en_US
dc.identifier.scopusauthoridLau, YL=7201403380en_US

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