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Article: Protective effects of baicalin on Neuro2A cells under oxygen and glucose deprivation

TitleProtective effects of baicalin on Neuro2A cells under oxygen and glucose deprivation
Authors
KeywordsAnoxia
Baicalin
Ischemia
Neuro2a Cells
Issue Date2005
Citation
Chinese Pharmacological Bulletin, 2005, v. 21 n. 10, p. 1260-1262 How to Cite?
AbstractAim: Neural injury in the central nervous system following is chemic insult is believed to result from oxygen and glucose deprivation. In this study, baicalin was investigated for its neuroprotective effects against oxygen and glucose deprivation (OGD) in Neuro2A cells. Methods: Mitochondrial activity was assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction activity assay. Apoptosis was monitored with flow cytometry. It was found that baicalin increased MTT reduction activity and decreased percentage of apoptosis of the cultured Neuro2A cells. Results: Baicalin showed significant protective effects on the OGD-induced apoptosis in cultured Neuro2A cells. Conclusion: These results suggest that baicalin is an effective compound in preventing neurotoxicity induced by OGD and therefore deserves further scrutiny.
Persistent Identifierhttp://hdl.handle.net/10722/170360
ISSN
2015 SCImago Journal Rankings: 0.141

 

DC FieldValueLanguage
dc.contributor.authorWang, Xen_US
dc.contributor.authorCheung, PTen_US
dc.contributor.authorZhong, Len_US
dc.contributor.authorYu, XHen_US
dc.contributor.authorYang, YJen_US
dc.contributor.authorChen, GJen_US
dc.date.accessioned2012-10-30T06:07:47Z-
dc.date.available2012-10-30T06:07:47Z-
dc.date.issued2005en_US
dc.identifier.citationChinese Pharmacological Bulletin, 2005, v. 21 n. 10, p. 1260-1262en_US
dc.identifier.issn1001-1978en_US
dc.identifier.urihttp://hdl.handle.net/10722/170360-
dc.description.abstractAim: Neural injury in the central nervous system following is chemic insult is believed to result from oxygen and glucose deprivation. In this study, baicalin was investigated for its neuroprotective effects against oxygen and glucose deprivation (OGD) in Neuro2A cells. Methods: Mitochondrial activity was assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction activity assay. Apoptosis was monitored with flow cytometry. It was found that baicalin increased MTT reduction activity and decreased percentage of apoptosis of the cultured Neuro2A cells. Results: Baicalin showed significant protective effects on the OGD-induced apoptosis in cultured Neuro2A cells. Conclusion: These results suggest that baicalin is an effective compound in preventing neurotoxicity induced by OGD and therefore deserves further scrutiny.en_US
dc.languageengen_US
dc.relation.ispartofChinese Pharmacological Bulletinen_US
dc.subjectAnoxiaen_US
dc.subjectBaicalinen_US
dc.subjectIschemiaen_US
dc.subjectNeuro2a Cellsen_US
dc.titleProtective effects of baicalin on Neuro2A cells under oxygen and glucose deprivationen_US
dc.typeArticleen_US
dc.identifier.emailCheung, PT:ptcheung@hkucc.hku.hken_US
dc.identifier.authorityCheung, PT=rp00351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-29144487920en_US
dc.identifier.volume21en_US
dc.identifier.issue10en_US
dc.identifier.spage1260en_US
dc.identifier.epage1262en_US
dc.identifier.scopusauthoridWang, X=7501863183en_US
dc.identifier.scopusauthoridCheung, PT=7202595465en_US
dc.identifier.scopusauthoridZhong, L=8517639200en_US
dc.identifier.scopusauthoridYu, XH=8517639000en_US
dc.identifier.scopusauthoridYang, YJ=35312936400en_US
dc.identifier.scopusauthoridChen, GJ=10044754400en_US

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