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Article: Systemic oxygen saturation and coagulation factor abnormalities before and after the fontan procedure

TitleSystemic oxygen saturation and coagulation factor abnormalities before and after the fontan procedure
Authors
Issue Date2005
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 2005, v. 96 n. 11, p. 1571-1575 How to Cite?
AbstractCoagulation factor abnormalities are believed to predispose to increased risk for thromboembolism after the Fontan procedure. Recent data, however, suggest that coagulation abnormalities may precede the operation. This study determined coagulation factor abnormalities in patients with single-ventricle congenital heart defects before the Fontan procedure and compared the findings with age-matched post-Fontan patients and control subjects. Liver function, coagulation factor levels, and pulse oximetry readings were determined in 11 pre-Fontan patients aged 9.3 ± 5.6 years. The results were compared with those of 11 age-matched post-Fontan patients, at 9.1 ± 2.4 years after the Fontan procedure, and 11 age-matched controls by simple analysis of variance and post hoc Tukey's test. Liver function was normal in patients before and after surgery apart from mildly elevated bilirubin levels in post-Fontan patients (p = 0.027). When compared with controls, pre-Fontan patients had significantly lower levels of protein C; protein S; antithrombin III; and factors II, V, VII, and X and longer prothrombin times (all with p <0.05). When compared with post-Fontan patients, pre-Fontan patients had similarly lower levels of free protein S (p <0.001), protein C (p = 0.06), and antithrombin III (p = 0.001). Systemic oxygen saturation correlated positively with the levels of anticoagulants (protein C, protein S, antithrombin III) and procoagulants (factors II, V, VII, and X) (all with p <0.05, r = 0.33 to 0.61). In conclusion, the findings suggest that coagulation factor abnormalities precede the Fontan procedure and tend to normalize after the operation, relating perhaps to improved systemic oxygenation. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170358
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, EWYen_US
dc.contributor.authorChay, GWen_US
dc.contributor.authorMa, ESKen_US
dc.contributor.authorCheung, YFen_US
dc.date.accessioned2012-10-30T06:07:46Z-
dc.date.available2012-10-30T06:07:46Z-
dc.date.issued2005en_US
dc.identifier.citationAmerican Journal Of Cardiology, 2005, v. 96 n. 11, p. 1571-1575en_US
dc.identifier.issn0002-9149en_US
dc.identifier.urihttp://hdl.handle.net/10722/170358-
dc.description.abstractCoagulation factor abnormalities are believed to predispose to increased risk for thromboembolism after the Fontan procedure. Recent data, however, suggest that coagulation abnormalities may precede the operation. This study determined coagulation factor abnormalities in patients with single-ventricle congenital heart defects before the Fontan procedure and compared the findings with age-matched post-Fontan patients and control subjects. Liver function, coagulation factor levels, and pulse oximetry readings were determined in 11 pre-Fontan patients aged 9.3 ± 5.6 years. The results were compared with those of 11 age-matched post-Fontan patients, at 9.1 ± 2.4 years after the Fontan procedure, and 11 age-matched controls by simple analysis of variance and post hoc Tukey's test. Liver function was normal in patients before and after surgery apart from mildly elevated bilirubin levels in post-Fontan patients (p = 0.027). When compared with controls, pre-Fontan patients had significantly lower levels of protein C; protein S; antithrombin III; and factors II, V, VII, and X and longer prothrombin times (all with p <0.05). When compared with post-Fontan patients, pre-Fontan patients had similarly lower levels of free protein S (p <0.001), protein C (p = 0.06), and antithrombin III (p = 0.001). Systemic oxygen saturation correlated positively with the levels of anticoagulants (protein C, protein S, antithrombin III) and procoagulants (factors II, V, VII, and X) (all with p <0.05, r = 0.33 to 0.61). In conclusion, the findings suggest that coagulation factor abnormalities precede the Fontan procedure and tend to normalize after the operation, relating perhaps to improved systemic oxygenation. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshBlood Coagulation Disorders - Blood - Etiologyen_US
dc.subject.meshBlood Coagulation Factors - Metabolismen_US
dc.subject.meshChilden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshFontan Procedure - Adverse Effectsen_US
dc.subject.meshHeart Defects, Congenital - Blood - Surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshOximetryen_US
dc.subject.meshOxygen - Blooden_US
dc.subject.meshPostoperative Complications - Blood - Etiologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThromboembolism - Blood - Etiologyen_US
dc.titleSystemic oxygen saturation and coagulation factor abnormalities before and after the fontan procedureen_US
dc.typeArticleen_US
dc.identifier.emailCheung, YF:xfcheung@hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.amjcard.2005.07.074en_US
dc.identifier.pmid16310443-
dc.identifier.scopuseid_2-s2.0-28044452212en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28044452212&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume96en_US
dc.identifier.issue11en_US
dc.identifier.spage1571en_US
dc.identifier.epage1575en_US
dc.identifier.isiWOS:000234021900020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, EWY=9432819700en_US
dc.identifier.scopusauthoridChay, GW=9435530600en_US
dc.identifier.scopusauthoridMa, ESK=7202039934en_US
dc.identifier.scopusauthoridCheung, YF=7202111067en_US

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