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Article: Novel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosis

TitleNovel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosis
Authors
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
Journal Of The American College Of Cardiology, 2004, v. 43 n. 1, p. 120-124 How to Cite?
AbstractOBJECTIVES: We determined the profile of cardiovascular risk factors in children late after Kawasaki disease (KD) and compared it with that of age-matched healthy children. BACKGROUND: Concerns have been raised regarding the possibility of a predisposition of KD to premature atherosclerosis later in life. METHODS: A cohort of 102 subjects were studied: 37 KD patients with coronary aneurysms (group I), 29 KD patients with normal coronary arteries (group II), and 36 healthy age-matched children (group III). The fasting total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) A-I, apoB, and homocysteine levels were compared among the three groups. In addition, blood pressure and brachioradial arterial stiffness, as determined by pulse wave velocity (PWV), were measured and compared. RESULTS: Group I subjects had lower HDL cholesterol (p = 0.016) and apoA-I levels (p = 0.044) and higher apoB levels (p = 0.029) and PWV (p = 0.001) than group III control subjects. Likewise, the apoB levels (p = 0.007) and PWV (p = 0.042) were higher in group II than in III subjects, although their HDL cholesterol (p = 0.54) and apoA-I (p = 0.52) levels were similar. The LDL cholesterol levels were higher in group I and II patients than in controls, although not statistically significant (p = 0.17). Blood pressure and homocysteine levels did not differ among the groups. CONCLUSIONS: An adverse cardiovascular risk profile, as characterized by a proatherogenic alteration of the lipid profile and increased arterial stiffness, occurs in children after KD. The profile is worse in those with than in those without coronary aneurysms. © 2004 by the American College of Cardiology Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/170335
ISSN
2014 Impact Factor: 16.503
2013 SCImago Journal Rankings: 9.179
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_US
dc.contributor.authorYung, TCen_US
dc.contributor.authorTam, SCFen_US
dc.contributor.authorHo, MHKen_US
dc.contributor.authorChau, AKTen_US
dc.date.accessioned2012-10-30T06:07:34Z-
dc.date.available2012-10-30T06:07:34Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of The American College Of Cardiology, 2004, v. 43 n. 1, p. 120-124en_US
dc.identifier.issn0735-1097en_US
dc.identifier.urihttp://hdl.handle.net/10722/170335-
dc.description.abstractOBJECTIVES: We determined the profile of cardiovascular risk factors in children late after Kawasaki disease (KD) and compared it with that of age-matched healthy children. BACKGROUND: Concerns have been raised regarding the possibility of a predisposition of KD to premature atherosclerosis later in life. METHODS: A cohort of 102 subjects were studied: 37 KD patients with coronary aneurysms (group I), 29 KD patients with normal coronary arteries (group II), and 36 healthy age-matched children (group III). The fasting total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) A-I, apoB, and homocysteine levels were compared among the three groups. In addition, blood pressure and brachioradial arterial stiffness, as determined by pulse wave velocity (PWV), were measured and compared. RESULTS: Group I subjects had lower HDL cholesterol (p = 0.016) and apoA-I levels (p = 0.044) and higher apoB levels (p = 0.029) and PWV (p = 0.001) than group III control subjects. Likewise, the apoB levels (p = 0.007) and PWV (p = 0.042) were higher in group II than in III subjects, although their HDL cholesterol (p = 0.54) and apoA-I (p = 0.52) levels were similar. The LDL cholesterol levels were higher in group I and II patients than in controls, although not statistically significant (p = 0.17). Blood pressure and homocysteine levels did not differ among the groups. CONCLUSIONS: An adverse cardiovascular risk profile, as characterized by a proatherogenic alteration of the lipid profile and increased arterial stiffness, occurs in children after KD. The profile is worse in those with than in those without coronary aneurysms. © 2004 by the American College of Cardiology Foundation.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_US
dc.relation.ispartofJournal of the American College of Cardiologyen_US
dc.subject.meshCardiovascular Diseases - Blood - Epidemiology - Etiologyen_US
dc.subject.meshChilden_US
dc.subject.meshCholesterol, Hdl - Blooden_US
dc.subject.meshCholesterol, Ldl - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMucocutaneous Lymph Node Syndrome - Blood - Complicationsen_US
dc.subject.meshRisk Factorsen_US
dc.titleNovel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosisen_US
dc.typeArticleen_US
dc.identifier.emailCheung, YF:xfcheung@hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jacc.2003.08.030en_US
dc.identifier.pmid14715193en_US
dc.identifier.scopuseid_2-s2.0-0347683345en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347683345&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume43en_US
dc.identifier.issue1en_US
dc.identifier.spage120en_US
dc.identifier.epage124en_US
dc.identifier.isiWOS:000187795400022-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, YF=7202111067en_US
dc.identifier.scopusauthoridYung, TC=9132842300en_US
dc.identifier.scopusauthoridTam, SCF=7202037323en_US
dc.identifier.scopusauthoridHo, MHK=8925896400en_US
dc.identifier.scopusauthoridChau, AKT=35787094400en_US

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