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Article: Novel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosis
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TitleNovel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosis
 
AuthorsCheung, YF1
Yung, TC1
Tam, SCF2
Ho, MHK1
Chau, AKT1
 
Issue Date2004
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
 
CitationJournal Of The American College Of Cardiology, 2004, v. 43 n. 1, p. 120-124 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jacc.2003.08.030
 
AbstractOBJECTIVES: We determined the profile of cardiovascular risk factors in children late after Kawasaki disease (KD) and compared it with that of age-matched healthy children. BACKGROUND: Concerns have been raised regarding the possibility of a predisposition of KD to premature atherosclerosis later in life. METHODS: A cohort of 102 subjects were studied: 37 KD patients with coronary aneurysms (group I), 29 KD patients with normal coronary arteries (group II), and 36 healthy age-matched children (group III). The fasting total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) A-I, apoB, and homocysteine levels were compared among the three groups. In addition, blood pressure and brachioradial arterial stiffness, as determined by pulse wave velocity (PWV), were measured and compared. RESULTS: Group I subjects had lower HDL cholesterol (p = 0.016) and apoA-I levels (p = 0.044) and higher apoB levels (p = 0.029) and PWV (p = 0.001) than group III control subjects. Likewise, the apoB levels (p = 0.007) and PWV (p = 0.042) were higher in group II than in III subjects, although their HDL cholesterol (p = 0.54) and apoA-I (p = 0.52) levels were similar. The LDL cholesterol levels were higher in group I and II patients than in controls, although not statistically significant (p = 0.17). Blood pressure and homocysteine levels did not differ among the groups. CONCLUSIONS: An adverse cardiovascular risk profile, as characterized by a proatherogenic alteration of the lipid profile and increased arterial stiffness, occurs in children after KD. The profile is worse in those with than in those without coronary aneurysms. © 2004 by the American College of Cardiology Foundation.
 
ISSN0735-1097
2013 Impact Factor: 15.343
2013 SCImago Journal Rankings: 9.179
 
DOIhttp://dx.doi.org/10.1016/j.jacc.2003.08.030
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, YF
 
dc.contributor.authorYung, TC
 
dc.contributor.authorTam, SCF
 
dc.contributor.authorHo, MHK
 
dc.contributor.authorChau, AKT
 
dc.date.accessioned2012-10-30T06:07:34Z
 
dc.date.available2012-10-30T06:07:34Z
 
dc.date.issued2004
 
dc.description.abstractOBJECTIVES: We determined the profile of cardiovascular risk factors in children late after Kawasaki disease (KD) and compared it with that of age-matched healthy children. BACKGROUND: Concerns have been raised regarding the possibility of a predisposition of KD to premature atherosclerosis later in life. METHODS: A cohort of 102 subjects were studied: 37 KD patients with coronary aneurysms (group I), 29 KD patients with normal coronary arteries (group II), and 36 healthy age-matched children (group III). The fasting total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) A-I, apoB, and homocysteine levels were compared among the three groups. In addition, blood pressure and brachioradial arterial stiffness, as determined by pulse wave velocity (PWV), were measured and compared. RESULTS: Group I subjects had lower HDL cholesterol (p = 0.016) and apoA-I levels (p = 0.044) and higher apoB levels (p = 0.029) and PWV (p = 0.001) than group III control subjects. Likewise, the apoB levels (p = 0.007) and PWV (p = 0.042) were higher in group II than in III subjects, although their HDL cholesterol (p = 0.54) and apoA-I (p = 0.52) levels were similar. The LDL cholesterol levels were higher in group I and II patients than in controls, although not statistically significant (p = 0.17). Blood pressure and homocysteine levels did not differ among the groups. CONCLUSIONS: An adverse cardiovascular risk profile, as characterized by a proatherogenic alteration of the lipid profile and increased arterial stiffness, occurs in children after KD. The profile is worse in those with than in those without coronary aneurysms. © 2004 by the American College of Cardiology Foundation.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of The American College Of Cardiology, 2004, v. 43 n. 1, p. 120-124 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jacc.2003.08.030
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jacc.2003.08.030
 
dc.identifier.epage124
 
dc.identifier.issn0735-1097
2013 Impact Factor: 15.343
2013 SCImago Journal Rankings: 9.179
 
dc.identifier.issue1
 
dc.identifier.pmid14715193
 
dc.identifier.scopuseid_2-s2.0-0347683345
 
dc.identifier.spage120
 
dc.identifier.urihttp://hdl.handle.net/10722/170335
 
dc.identifier.volume43
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of the American College of Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCardiovascular Diseases - Blood - Epidemiology - Etiology
 
dc.subject.meshChild
 
dc.subject.meshCholesterol, Hdl - Blood
 
dc.subject.meshCholesterol, Ldl - Blood
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMucocutaneous Lymph Node Syndrome - Blood - Complications
 
dc.subject.meshRisk Factors
 
dc.titleNovel and Traditional Cardiovascular Risk Factors in Children after Kawasaki Disease: Implications for Premature Atherosclerosis
 
dc.typeArticle
 
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<contributor.author>Tam, SCF</contributor.author>
<contributor.author>Ho, MHK</contributor.author>
<contributor.author>Chau, AKT</contributor.author>
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<description.abstract>OBJECTIVES: We determined the profile of cardiovascular risk factors in children late after Kawasaki disease (KD) and compared it with that of age-matched healthy children. BACKGROUND: Concerns have been raised regarding the possibility of a predisposition of KD to premature atherosclerosis later in life. METHODS: A cohort of 102 subjects were studied: 37 KD patients with coronary aneurysms (group I), 29 KD patients with normal coronary arteries (group II), and 36 healthy age-matched children (group III). The fasting total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) A-I, apoB, and homocysteine levels were compared among the three groups. In addition, blood pressure and brachioradial arterial stiffness, as determined by pulse wave velocity (PWV), were measured and compared. RESULTS: Group I subjects had lower HDL cholesterol (p = 0.016) and apoA-I levels (p = 0.044) and higher apoB levels (p = 0.029) and PWV (p = 0.001) than group III control subjects. Likewise, the apoB levels (p = 0.007) and PWV (p = 0.042) were higher in group II than in III subjects, although their HDL cholesterol (p = 0.54) and apoA-I (p = 0.52) levels were similar. The LDL cholesterol levels were higher in group I and II patients than in controls, although not statistically significant (p = 0.17). Blood pressure and homocysteine levels did not differ among the groups. CONCLUSIONS: An adverse cardiovascular risk profile, as characterized by a proatherogenic alteration of the lipid profile and increased arterial stiffness, occurs in children after KD. The profile is worse in those with than in those without coronary aneurysms. &#169; 2004 by the American College of Cardiology Foundation.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong