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Article: IGF-I increases interferon-γ and IL-6 mRNA expression and protein production in neonatal mononuclear cells

TitleIGF-I increases interferon-γ and IL-6 mRNA expression and protein production in neonatal mononuclear cells
Authors
Issue Date1999
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/
Citation
Pediatric Research, 1999, v. 46 n. 6, p. 748-754 How to Cite?
AbstractNeonates are vulnerable to infections because of their immature immunity. IGF-I has been reported to have profound positive effects on immune function. In this study, we investigated the effects of IGF-I on neonatal immunity. The production of IL-2, IL-4, and interferon-γ in phytohemagglutinin (PHA)-stimulated neonatal mononuclear cells (MNC) was significantly decreased when compared with that of adults. IGF-I alone induced a high level of IL-6 mRNA expression and protein production in neonatal MNC. IGF-I significantly increased mRNA expression and protein production of both IL-6 and interferon-γ but had no influence on that of IL- 2 and IL-4 in PHA-stimulated neonatal MNC. Moreover, it increased neonatal interferon-γ production in PHA-stimulated MNC to a level similar to that of adults. IGF-I could further enhance the mRNA expression of lymphocyte- activation gene 3, which is associated with interferon-γ production and differentiation of T-helper 1 lymphocytes, in PHA-stimulated neonatal MNC. These results suggest IGF-I could promote maturation of neonatal T cells, and its potential use to enhance neonatal immunity deserves further study.
Persistent Identifierhttp://hdl.handle.net/10722/170334
ISSN
2015 Impact Factor: 2.761
2015 SCImago Journal Rankings: 1.290
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWenwei, Ten_US
dc.contributor.authorCheung, PTen_US
dc.contributor.authorLau, YLen_US
dc.date.accessioned2012-10-30T06:07:33Z-
dc.date.available2012-10-30T06:07:33Z-
dc.date.issued1999en_US
dc.identifier.citationPediatric Research, 1999, v. 46 n. 6, p. 748-754en_US
dc.identifier.issn0031-3998en_US
dc.identifier.urihttp://hdl.handle.net/10722/170334-
dc.description.abstractNeonates are vulnerable to infections because of their immature immunity. IGF-I has been reported to have profound positive effects on immune function. In this study, we investigated the effects of IGF-I on neonatal immunity. The production of IL-2, IL-4, and interferon-γ in phytohemagglutinin (PHA)-stimulated neonatal mononuclear cells (MNC) was significantly decreased when compared with that of adults. IGF-I alone induced a high level of IL-6 mRNA expression and protein production in neonatal MNC. IGF-I significantly increased mRNA expression and protein production of both IL-6 and interferon-γ but had no influence on that of IL- 2 and IL-4 in PHA-stimulated neonatal MNC. Moreover, it increased neonatal interferon-γ production in PHA-stimulated MNC to a level similar to that of adults. IGF-I could further enhance the mRNA expression of lymphocyte- activation gene 3, which is associated with interferon-γ production and differentiation of T-helper 1 lymphocytes, in PHA-stimulated neonatal MNC. These results suggest IGF-I could promote maturation of neonatal T cells, and its potential use to enhance neonatal immunity deserves further study.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/en_US
dc.relation.ispartofPediatric Researchen_US
dc.rightsPediatric Research. Copyright © Lippincott Williams & Wilkins.-
dc.subject.meshAdulten_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshFetal Blooden_US
dc.subject.meshGene Expression Regulation - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-Like Growth Factor I - Pharmacologyen_US
dc.subject.meshInterferon-Gamma - Biosynthesisen_US
dc.subject.meshInterleukin-6 - Biosynthesisen_US
dc.subject.meshLeukocytes, Mononuclear - Metabolismen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRna, Messenger - Biosynthesisen_US
dc.titleIGF-I increases interferon-γ and IL-6 mRNA expression and protein production in neonatal mononuclear cellsen_US
dc.typeArticleen_US
dc.identifier.emailWenwei, T:wwtu@hkucc.hku.hken_US
dc.identifier.emailCheung, PT:ptcheung@hkucc.hku.hken_US
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_US
dc.identifier.authorityWenwei, T=rp00416en_US
dc.identifier.authorityCheung, PT=rp00351en_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1203/00006450-199912000-00018-
dc.identifier.pmid10590034-
dc.identifier.scopuseid_2-s2.0-0345580185en_US
dc.identifier.hkuros47556-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0345580185&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume46en_US
dc.identifier.issue6en_US
dc.identifier.spage748en_US
dc.identifier.epage754en_US
dc.identifier.isiWOS:000083870200018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWenwei, T=7006479236en_US
dc.identifier.scopusauthoridCheung, PT=7202595465en_US
dc.identifier.scopusauthoridLau, YL=7201403380en_US

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