File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Analysis of indications for surgical closure of subarterial ventricular septal defect without associated aortic cusp prolapse and aortic regurgitation
  • Basic View
  • Metadata View
  • XML View
TitleAnalysis of indications for surgical closure of subarterial ventricular septal defect without associated aortic cusp prolapse and aortic regurgitation
 
AuthorsLun, KS1
Li, H1
Leung, MP1
Chau, AKT1
Yung, TC1
Chiu, CSW1
Cheung, YF1 2
 
Issue Date2001
 
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
 
CitationAmerican Journal Of Cardiology, 2001, v. 87 n. 11, p. 1266-1270 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0002-9149(01)01517-X
 
AbstractSubarterial ventricular septal defect (VSD) is relatively common in Orientals. We reviewed the outcome of 214 patients (137 males) who were followed for 8.6 ± 5.2 years (range 0.1 to 24.3) and addressed the issue regarding the necessity and optimum timing of closing subarterial defects before development of aortic valve deformities. Demographic data, transthoracic and transesophageal echocardiographic findings, cardiac catheterization results, and operative findings were reviewed. Kaplan-Meier actuarial analysis was performed to assess the development of aortic valve complications over time. Seventy-five patients with heart failure and pulmonary hypertension underwent surgical closure of VSD at the age of 2.4 ± 2.9 years. No patient had aortic cusp prolapse before operation and none developed aortic cusp prolapse or aortic regurgitation (AR) on follow-up. In contrast, of the 139 asymptomatic patients managed conservatively, 102 (73%) developed aortic cusp prolapse, 78% of whom (80 of 102) developed AR. The prevalence of aortic cusp prolapse and AR at 1, 5, 10, and 15 years old was 8%, 30%, 64%, and 83%, and 3%, 24%, 45%, and 64%, respectively. Significant prolapse or AR prompted surgical closure of VSD with (n = 22) or without (n = 26) valvoplasty in 48 of 102 patients (47%). The size of the VSD was significantly larger in patients with heart failure (9.6 ± 3.3 mm) or aortic cusp prolapse (11.7 ± 4.1 mm) compared with those without heart failure (4.5 ± 1.4 mm, p <0.001). All patients with aortic cusp prolapse and all but 1 with heart failure had a defect size of ≥5 mm. In conclusion, subarterial VSD of ≥5 mm should be closed as early as possible to prevent development of aortic cusp prolapse and AR. Asymptomatic patients with small defects <5 mm could be managed conservatively. © 2001 Excerpta Medica, Inc.
 
ISSN0002-9149
2013 Impact Factor: 3.425
2013 SCImago Journal Rankings: 2.315
 
DOIhttp://dx.doi.org/10.1016/S0002-9149(01)01517-X
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLun, KS
 
dc.contributor.authorLi, H
 
dc.contributor.authorLeung, MP
 
dc.contributor.authorChau, AKT
 
dc.contributor.authorYung, TC
 
dc.contributor.authorChiu, CSW
 
dc.contributor.authorCheung, YF
 
dc.date.accessioned2012-10-30T06:07:25Z
 
dc.date.available2012-10-30T06:07:25Z
 
dc.date.issued2001
 
dc.description.abstractSubarterial ventricular septal defect (VSD) is relatively common in Orientals. We reviewed the outcome of 214 patients (137 males) who were followed for 8.6 ± 5.2 years (range 0.1 to 24.3) and addressed the issue regarding the necessity and optimum timing of closing subarterial defects before development of aortic valve deformities. Demographic data, transthoracic and transesophageal echocardiographic findings, cardiac catheterization results, and operative findings were reviewed. Kaplan-Meier actuarial analysis was performed to assess the development of aortic valve complications over time. Seventy-five patients with heart failure and pulmonary hypertension underwent surgical closure of VSD at the age of 2.4 ± 2.9 years. No patient had aortic cusp prolapse before operation and none developed aortic cusp prolapse or aortic regurgitation (AR) on follow-up. In contrast, of the 139 asymptomatic patients managed conservatively, 102 (73%) developed aortic cusp prolapse, 78% of whom (80 of 102) developed AR. The prevalence of aortic cusp prolapse and AR at 1, 5, 10, and 15 years old was 8%, 30%, 64%, and 83%, and 3%, 24%, 45%, and 64%, respectively. Significant prolapse or AR prompted surgical closure of VSD with (n = 22) or without (n = 26) valvoplasty in 48 of 102 patients (47%). The size of the VSD was significantly larger in patients with heart failure (9.6 ± 3.3 mm) or aortic cusp prolapse (11.7 ± 4.1 mm) compared with those without heart failure (4.5 ± 1.4 mm, p <0.001). All patients with aortic cusp prolapse and all but 1 with heart failure had a defect size of ≥5 mm. In conclusion, subarterial VSD of ≥5 mm should be closed as early as possible to prevent development of aortic cusp prolapse and AR. Asymptomatic patients with small defects <5 mm could be managed conservatively. © 2001 Excerpta Medica, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Cardiology, 2001, v. 87 n. 11, p. 1266-1270 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0002-9149(01)01517-X
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0002-9149(01)01517-X
 
dc.identifier.epage1270
 
dc.identifier.issn0002-9149
2013 Impact Factor: 3.425
2013 SCImago Journal Rankings: 2.315
 
dc.identifier.issue11
 
dc.identifier.pmid11377352
 
dc.identifier.scopuseid_2-s2.0-0035371337
 
dc.identifier.spage1266
 
dc.identifier.urihttp://hdl.handle.net/10722/170312
 
dc.identifier.volume87
 
dc.languageeng
 
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAortic Valve Insufficiency - Surgery - Ultrasonography
 
dc.subject.meshAortic Valve Prolapse - Surgery - Ultrasonography
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshEchocardiography
 
dc.subject.meshEchocardiography, Transesophageal
 
dc.subject.meshFemale
 
dc.subject.meshFollow-Up Studies
 
dc.subject.meshHeart Catheterization
 
dc.subject.meshHeart Defects, Congenital - Surgery - Ultrasonography
 
dc.subject.meshHeart Septal Defects, Ventricular - Surgery - Ultrasonography
 
dc.subject.meshHumans
 
dc.subject.meshInfant
 
dc.subject.meshInfant, Newborn
 
dc.subject.meshMale
 
dc.subject.meshPostoperative Complications - Ultrasonography
 
dc.subject.meshTreatment Outcome
 
dc.titleAnalysis of indications for surgical closure of subarterial ventricular septal defect without associated aortic cusp prolapse and aortic regurgitation
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Lun, KS</contributor.author>
<contributor.author>Li, H</contributor.author>
<contributor.author>Leung, MP</contributor.author>
<contributor.author>Chau, AKT</contributor.author>
<contributor.author>Yung, TC</contributor.author>
<contributor.author>Chiu, CSW</contributor.author>
<contributor.author>Cheung, YF</contributor.author>
<date.accessioned>2012-10-30T06:07:25Z</date.accessioned>
<date.available>2012-10-30T06:07:25Z</date.available>
<date.issued>2001</date.issued>
<identifier.citation>American Journal Of Cardiology, 2001, v. 87 n. 11, p. 1266-1270</identifier.citation>
<identifier.issn>0002-9149</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/170312</identifier.uri>
<description.abstract>Subarterial ventricular septal defect (VSD) is relatively common in Orientals. We reviewed the outcome of 214 patients (137 males) who were followed for 8.6 &#177; 5.2 years (range 0.1 to 24.3) and addressed the issue regarding the necessity and optimum timing of closing subarterial defects before development of aortic valve deformities. Demographic data, transthoracic and transesophageal echocardiographic findings, cardiac catheterization results, and operative findings were reviewed. Kaplan-Meier actuarial analysis was performed to assess the development of aortic valve complications over time. Seventy-five patients with heart failure and pulmonary hypertension underwent surgical closure of VSD at the age of 2.4 &#177; 2.9 years. No patient had aortic cusp prolapse before operation and none developed aortic cusp prolapse or aortic regurgitation (AR) on follow-up. In contrast, of the 139 asymptomatic patients managed conservatively, 102 (73%) developed aortic cusp prolapse, 78% of whom (80 of 102) developed AR. The prevalence of aortic cusp prolapse and AR at 1, 5, 10, and 15 years old was 8%, 30%, 64%, and 83%, and 3%, 24%, 45%, and 64%, respectively. Significant prolapse or AR prompted surgical closure of VSD with (n = 22) or without (n = 26) valvoplasty in 48 of 102 patients (47%). The size of the VSD was significantly larger in patients with heart failure (9.6 &#177; 3.3 mm) or aortic cusp prolapse (11.7 &#177; 4.1 mm) compared with those without heart failure (4.5 &#177; 1.4 mm, p &lt;0.001). All patients with aortic cusp prolapse and all but 1 with heart failure had a defect size of &#8805;5 mm. In conclusion, subarterial VSD of &#8805;5 mm should be closed as early as possible to prevent development of aortic cusp prolapse and AR. Asymptomatic patients with small defects &lt;5 mm could be managed conservatively. &#169; 2001 Excerpta Medica, Inc.</description.abstract>
<language>eng</language>
<publisher>Excerpta Medica, Inc.. The Journal&apos;s web site is located at http://www.ajconline.org/</publisher>
<relation.ispartof>American Journal of Cardiology</relation.ispartof>
<subject.mesh>Adolescent</subject.mesh>
<subject.mesh>Aortic Valve Insufficiency - Surgery - Ultrasonography</subject.mesh>
<subject.mesh>Aortic Valve Prolapse - Surgery - Ultrasonography</subject.mesh>
<subject.mesh>Child</subject.mesh>
<subject.mesh>Child, Preschool</subject.mesh>
<subject.mesh>Echocardiography</subject.mesh>
<subject.mesh>Echocardiography, Transesophageal</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Follow-Up Studies</subject.mesh>
<subject.mesh>Heart Catheterization</subject.mesh>
<subject.mesh>Heart Defects, Congenital - Surgery - Ultrasonography</subject.mesh>
<subject.mesh>Heart Septal Defects, Ventricular - Surgery - Ultrasonography</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Infant</subject.mesh>
<subject.mesh>Infant, Newborn</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Postoperative Complications - Ultrasonography</subject.mesh>
<subject.mesh>Treatment Outcome</subject.mesh>
<title>Analysis of indications for surgical closure of subarterial ventricular septal defect without associated aortic cusp prolapse and aortic regurgitation</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/S0002-9149(01)01517-X</identifier.doi>
<identifier.pmid>11377352</identifier.pmid>
<identifier.scopus>eid_2-s2.0-0035371337</identifier.scopus>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035371337&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>87</identifier.volume>
<identifier.issue>11</identifier.issue>
<identifier.spage>1266</identifier.spage>
<identifier.epage>1270</identifier.epage>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Grantham Hospital Hong Kong