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Article: Expression of soluble guanylyl cyclase gene in adult rat brain

TitleExpression of soluble guanylyl cyclase gene in adult rat brain
Authors
Issue Date1994
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
Citation
European Journal Of Neuroscience, 1994, v. 6 n. 2, p. 211-217 How to Cite?
AbstractThe synthesis of the intracellular messenger, cyclic GMP, is catalysed by particulate or soluble guanylyl cyclase (sGCY). sGCY is activated by nitric oxide, a compound with putative neurotransmitter functions, especially in long-term potentiation. Hybridization histochemistry with a probe complementary to the rat lung large (α1) subunit was used to assess the exact localization of sGCY mRNA in the rat brain. Many cells in the olfactory bulb contained sGCY mRNA. In the whole cerebral cortex, sGCY mRNA was found in all layers, with a predominance in layers II - III. A similar pattern was found in the olfactory tuberculum, in continuation with the piriform cortex and the cortical amygdaloid nucleus. All parts of the striatum expressed sGCY mRNA. sGCY mRNA was also found in the habenula medialis, in the pinealis in some diencephalic nuclei, and in the granule cell layers of the cerebellum. This study provides a description of the normal anatomy of sGCY gene expression in the rat forebrain as a basis for the study of the modulation of expression after physiological and pharmacological manipulations.
Persistent Identifierhttp://hdl.handle.net/10722/170273
ISSN
2015 Impact Factor: 2.975
2015 SCImago Journal Rankings: 2.130
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBurgunder, JMen_US
dc.contributor.authorCheung, PTen_US
dc.date.accessioned2012-10-30T06:07:07Z-
dc.date.available2012-10-30T06:07:07Z-
dc.date.issued1994en_US
dc.identifier.citationEuropean Journal Of Neuroscience, 1994, v. 6 n. 2, p. 211-217en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170273-
dc.description.abstractThe synthesis of the intracellular messenger, cyclic GMP, is catalysed by particulate or soluble guanylyl cyclase (sGCY). sGCY is activated by nitric oxide, a compound with putative neurotransmitter functions, especially in long-term potentiation. Hybridization histochemistry with a probe complementary to the rat lung large (α1) subunit was used to assess the exact localization of sGCY mRNA in the rat brain. Many cells in the olfactory bulb contained sGCY mRNA. In the whole cerebral cortex, sGCY mRNA was found in all layers, with a predominance in layers II - III. A similar pattern was found in the olfactory tuberculum, in continuation with the piriform cortex and the cortical amygdaloid nucleus. All parts of the striatum expressed sGCY mRNA. sGCY mRNA was also found in the habenula medialis, in the pinealis in some diencephalic nuclei, and in the granule cell layers of the cerebellum. This study provides a description of the normal anatomy of sGCY gene expression in the rat forebrain as a basis for the study of the modulation of expression after physiological and pharmacological manipulations.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJNen_US
dc.relation.ispartofEuropean Journal of Neuroscienceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlotting, Northernen_US
dc.subject.meshBrain - Cytology - Enzymologyen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshGuanylate Cyclase - Biosynthesisen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshLung - Enzymologyen_US
dc.subject.meshOrgan Specificityen_US
dc.subject.meshRna, Messenger - Analysis - Biosynthesisen_US
dc.subject.meshRatsen_US
dc.titleExpression of soluble guanylyl cyclase gene in adult rat brainen_US
dc.typeArticleen_US
dc.identifier.emailCheung, PT:ptcheung@hkucc.hku.hken_US
dc.identifier.authorityCheung, PT=rp00351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1460-9568.1994.tb00263.x-
dc.identifier.pmid7909483-
dc.identifier.scopuseid_2-s2.0-0028038954en_US
dc.identifier.volume6en_US
dc.identifier.issue2en_US
dc.identifier.spage211en_US
dc.identifier.epage217en_US
dc.identifier.isiWOS:A1994MW93000005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBurgunder, JM=7005647679en_US
dc.identifier.scopusauthoridCheung, PT=7202595465en_US

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