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Article: Biphasic rise of serum immunoglobulins G and A and sex influence on serum immunoglobulin M in normal Chinese children

TitleBiphasic rise of serum immunoglobulins G and A and sex influence on serum immunoglobulin M in normal Chinese children
Authors
Issue Date1992
Citation
Journal Of Paediatrics And Child Health, 1992, v. 28 n. 3, p. 240-243 How to Cite?
AbstractA study was conducted on 751 healthy children from child health clinics, kindergartens and schools, and 80 normal adults to establish reference ranges for serum immunoglobulins (Ig) G, A and M concentrations in normal Chinese. Serum IgG, IgA and IgM concentrations were determined by nephelometry. Serum IgG and IgA were shown to have a significant rise during the preschool age as well as at puberty with a plateau phase in between. This biphasic maturation profile has not been reported in Caucasians and the reasons for the observed difference have yet to be elucidated. Serum IgM concentrations were shown to be higher in females than in males, reaching significance in most age groups beyond 4 years of age. The difference between the two sexes in Chinese was of similar magnitude as that reported for Blacks and Caucasians, that is, 30%. Our findings support the hypothesis that the human X chromosome may carry quantitative genes for IgM.
Persistent Identifierhttp://hdl.handle.net/10722/170261
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, YLen_US
dc.contributor.authorJones, BMen_US
dc.contributor.authorYeung, CYen_US
dc.date.accessioned2012-10-30T06:07:02Z-
dc.date.available2012-10-30T06:07:02Z-
dc.date.issued1992en_US
dc.identifier.citationJournal Of Paediatrics And Child Health, 1992, v. 28 n. 3, p. 240-243en_US
dc.identifier.issn0004-993Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170261-
dc.description.abstractA study was conducted on 751 healthy children from child health clinics, kindergartens and schools, and 80 normal adults to establish reference ranges for serum immunoglobulins (Ig) G, A and M concentrations in normal Chinese. Serum IgG, IgA and IgM concentrations were determined by nephelometry. Serum IgG and IgA were shown to have a significant rise during the preschool age as well as at puberty with a plateau phase in between. This biphasic maturation profile has not been reported in Caucasians and the reasons for the observed difference have yet to be elucidated. Serum IgM concentrations were shown to be higher in females than in males, reaching significance in most age groups beyond 4 years of age. The difference between the two sexes in Chinese was of similar magnitude as that reported for Blacks and Caucasians, that is, 30%. Our findings support the hypothesis that the human X chromosome may carry quantitative genes for IgM.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Paediatrics and Child Healthen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A - Analysisen_US
dc.subject.meshImmunoglobulin G - Analysisen_US
dc.subject.meshImmunoglobulin M - Analysisen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSex Factorsen_US
dc.titleBiphasic rise of serum immunoglobulins G and A and sex influence on serum immunoglobulin M in normal Chinese childrenen_US
dc.typeArticleen_US
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1754.1992.tb02654.x-
dc.identifier.pmid1605976-
dc.identifier.scopuseid_2-s2.0-0026728999en_US
dc.identifier.volume28en_US
dc.identifier.issue3en_US
dc.identifier.spage240en_US
dc.identifier.epage243en_US
dc.identifier.isiWOS:A1992HX17400011-
dc.identifier.scopusauthoridLau, YL=7201403380en_US
dc.identifier.scopusauthoridJones, BM=7404958958en_US
dc.identifier.scopusauthoridYeung, CY=7201354144en_US

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