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Article: Defective neutrophil and lymphocyte function in leucocyte adhesion deficiency

TitleDefective neutrophil and lymphocyte function in leucocyte adhesion deficiency
Authors
KeywordsChinese
LFA-1
Mac-1
memory T cells
plaque-forming cells
Issue Date1991
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEI
Citation
Clinical And Experimental Immunology, 1991, v. 85 n. 2, p. 202-208 How to Cite?
AbstractWe report a Chinese girl with the moderate phenotype of leucocyte adhesion deficiency (LAD), presenting with persistent omphalitis and recurrent soft tissue infections. She had subnormal adhesion-dependent neutrophil functions, such as chemotaxis and chemiluminescence response to a particulate stimulant (opsonised zymosan). Despite her adequate humoral respouse to documcuted herpes simplex virus type 1, parainfluenza type 2 and adenovirus infection in vivo, there was marked impairment in the generation of plaque-forming cells (PFC) driven by pokeweed mitogen (PWM) in vitro. IgM PFC were less severely affected than IgG and IgA PFC, probably because IgM production is less dependent on T cell help than IgA and IgG production. The patient's B cells and accessory cells had reduced function compared with the control subsets, while helper function of her CD4+ cells was virtually absent in the PWM-driven PFC assay. She also had marked defect in natural killer cell activity. The proliferation of her lymphocytes was normal to several plant lectins, including phytohaemagglutinin, concanavalin A and PWM, but markedly defective to OKT3.
Persistent Identifierhttp://hdl.handle.net/10722/170245
ISSN
2015 Impact Factor: 3.148
2015 SCImago Journal Rankings: 1.369
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, YLen_HK
dc.contributor.authorLow, LCKen_HK
dc.contributor.authorJones, BMen_HK
dc.contributor.authorLawton, JWMen_HK
dc.date.accessioned2012-10-30T06:06:55Z-
dc.date.available2012-10-30T06:06:55Z-
dc.date.issued1991en_HK
dc.identifier.citationClinical And Experimental Immunology, 1991, v. 85 n. 2, p. 202-208en_HK
dc.identifier.issn0009-9104en_HK
dc.identifier.urihttp://hdl.handle.net/10722/170245-
dc.description.abstractWe report a Chinese girl with the moderate phenotype of leucocyte adhesion deficiency (LAD), presenting with persistent omphalitis and recurrent soft tissue infections. She had subnormal adhesion-dependent neutrophil functions, such as chemotaxis and chemiluminescence response to a particulate stimulant (opsonised zymosan). Despite her adequate humoral respouse to documcuted herpes simplex virus type 1, parainfluenza type 2 and adenovirus infection in vivo, there was marked impairment in the generation of plaque-forming cells (PFC) driven by pokeweed mitogen (PWM) in vitro. IgM PFC were less severely affected than IgG and IgA PFC, probably because IgM production is less dependent on T cell help than IgA and IgG production. The patient's B cells and accessory cells had reduced function compared with the control subsets, while helper function of her CD4+ cells was virtually absent in the PWM-driven PFC assay. She also had marked defect in natural killer cell activity. The proliferation of her lymphocytes was normal to several plant lectins, including phytohaemagglutinin, concanavalin A and PWM, but markedly defective to OKT3.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEIen_HK
dc.relation.ispartofClinical and Experimental Immunologyen_HK
dc.subjectChineseen_HK
dc.subjectLFA-1en_HK
dc.subjectMac-1en_HK
dc.subjectmemory T cellsen_HK
dc.subjectplaque-forming cellsen_HK
dc.subject.meshAntigens, Cd - Deficiencyen_US
dc.subject.meshAntigens, Cd18en_US
dc.subject.meshCell Adhesionen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshHumansen_US
dc.subject.meshKiller Cells, Natural - Immunologyen_US
dc.subject.meshLeukocyte-Adhesion Deficiency Syndromeen_US
dc.subject.meshLymphocytes - Immunologyen_US
dc.subject.meshMacrophage-1 Antigen - Deficiencyen_US
dc.subject.meshNeutrophils - Immunologyen_US
dc.titleDefective neutrophil and lymphocyte function in leucocyte adhesion deficiencyen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityLow, LCK=rp00337en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1677833-
dc.identifier.scopuseid_2-s2.0-0025739184en_HK
dc.identifier.volume85en_HK
dc.identifier.issue2en_HK
dc.identifier.spage202en_HK
dc.identifier.epage208en_HK
dc.identifier.isiWOS:A1991FY64200004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridLow, LCK=7007049461en_HK
dc.identifier.scopusauthoridJones, BM=7404958958en_HK
dc.identifier.scopusauthoridLawton, JWM=7102180792en_HK

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