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Article: Spontaneous tumor necrosis factor production in Kawasaki disease

TitleSpontaneous tumor necrosis factor production in Kawasaki disease
Authors
Issue Date1989
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jpeds
Citation
Journal Of Pediatrics, 1989, v. 115 n. 6, p. 939-943 How to Cite?
AbstractTumor necrosis factor production by peripheral blood mononuclear cells was measured in 18 patients with Kawasaki disease. In patients studied during the acute febrile phase of their disease, there was increased spontaneous TNF production (mean 26.9 ± 40.3 U/ml) compared with that of control subjects (1.0 ± .86 U/ml) (p ≤ 0.025). Spontaneous TNF production by patients tested in the subacute or convalescent phase of the illness was significantly lower than that in patients tested during the acute illness (p ≤ 0.025). In all patients studied with serial acute and subacute-convalescent samples, TNF production was normal in the follow-up samples. Because TNF is a potent mediator of inflammation and causes damage to vascular endothelial cells, we suggest that TNF may be important in the pathogenesis of both the immune activation and endothelial cell damage characteristic of this illness.
Persistent Identifierhttp://hdl.handle.net/10722/170235
ISSN
2015 Impact Factor: 3.89
2015 SCImago Journal Rankings: 1.849
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, BAen_US
dc.contributor.authorSilverman, EDen_US
dc.contributor.authorLaxer, RMen_US
dc.contributor.authorLau, ASen_US
dc.date.accessioned2012-10-30T06:06:53Z-
dc.date.available2012-10-30T06:06:53Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Pediatrics, 1989, v. 115 n. 6, p. 939-943en_US
dc.identifier.issn0022-3476en_US
dc.identifier.urihttp://hdl.handle.net/10722/170235-
dc.description.abstractTumor necrosis factor production by peripheral blood mononuclear cells was measured in 18 patients with Kawasaki disease. In patients studied during the acute febrile phase of their disease, there was increased spontaneous TNF production (mean 26.9 ± 40.3 U/ml) compared with that of control subjects (1.0 ± .86 U/ml) (p ≤ 0.025). Spontaneous TNF production by patients tested in the subacute or convalescent phase of the illness was significantly lower than that in patients tested during the acute illness (p ≤ 0.025). In all patients studied with serial acute and subacute-convalescent samples, TNF production was normal in the follow-up samples. Because TNF is a potent mediator of inflammation and causes damage to vascular endothelial cells, we suggest that TNF may be important in the pathogenesis of both the immune activation and endothelial cell damage characteristic of this illness.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jpedsen_US
dc.relation.ispartofJournal of Pediatricsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization, Passiveen_US
dc.subject.meshInfanten_US
dc.subject.meshLeukocytes, Mononuclear - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMucocutaneous Lymph Node Syndrome - Blood - Etiology - Therapyen_US
dc.subject.meshTumor Necrosis Factor-Alpha - Analysis - Biosynthesisen_US
dc.titleSpontaneous tumor necrosis factor production in Kawasaki diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLau, AS:asylau@hku.hken_US
dc.identifier.authorityLau, AS=rp00474en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0022-3476(89)80746-2en_US
dc.identifier.pmid2585231-
dc.identifier.scopuseid_2-s2.0-0024408746en_US
dc.identifier.volume115en_US
dc.identifier.issue6en_US
dc.identifier.spage939en_US
dc.identifier.epage943en_US
dc.identifier.isiWOS:A1989CC75800012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLang, BA=25933039000en_US
dc.identifier.scopusauthoridSilverman, ED=7201672786en_US
dc.identifier.scopusauthoridLaxer, RM=7005728630en_US
dc.identifier.scopusauthoridLau, AS=7202626202en_US

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