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Article: Strong association of HLA-DR3/DRw9 heterozygosity with early-onset insulin-dependent diabetes mellitus in Chinese

TitleStrong association of HLA-DR3/DRw9 heterozygosity with early-onset insulin-dependent diabetes mellitus in Chinese
Authors
Issue Date1987
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes, 1987, v. 36 n. 11, p. 1297-1300 How to Cite?
AbstractStudies of Caucasian and Japanese patients with insulin-dependent diabetes mellitus (IDDM) have shown that heterozygosity for certain HLA-DR antigens confers a high risk of developing the disease. The HLA antigens of 75 Chinese patients and 100 Chinese controls in Hong Kong were studied to investigate the role of HLA-DR heterozygosity in Chinese individuals. Some of the patients and controls were also tested for allotypic variation in the complement components C2, C4, and BF. Three alleles, Aw33, B17, and DR3, had increased frequencies in patients compared with controls and frequently occurred together in the same phenotype, which suggested their existence as a haplotype. There were no statistically significant differences in complement allotype frequencies between patients and controls, although the C4B null allele seemed to be associated with Aw33, B17, and DR3. No other HLA-DR antigen appeared to be associated with IDDM. However, when the patients were separated on the basis of age at onset, the frequency of DR3/DRw9 heterozygosity was markedly increased in patients presenting in the first decade of life, but there was no increase in patients presenting at >20 yr of age. DRw9 is strongly associated with autoimmune disease in Chinese, whereas DR3 is not. We suggest that the major IDDM susceptibility locus in Chinese is associated with HLA-DR3 and that patients with HLA-DR3 and HLA-DRw9 have an added predisposition to autoimmune disease and therefore develop IDDM earlier than patients without DRw9.
Persistent Identifierhttp://hdl.handle.net/10722/170224
ISSN
2015 Impact Factor: 8.784
2015 SCImago Journal Rankings: 5.185
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHawkins, BRen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorMa, JTCen_US
dc.contributor.authorLow, LCKen_US
dc.contributor.authorCheung, PTen_US
dc.contributor.authorSerjeantson, SWen_US
dc.contributor.authorYeung, RTTen_US
dc.date.accessioned2012-10-30T06:06:48Z-
dc.date.available2012-10-30T06:06:48Z-
dc.date.issued1987en_US
dc.identifier.citationDiabetes, 1987, v. 36 n. 11, p. 1297-1300en_US
dc.identifier.issn0012-1797en_US
dc.identifier.urihttp://hdl.handle.net/10722/170224-
dc.description.abstractStudies of Caucasian and Japanese patients with insulin-dependent diabetes mellitus (IDDM) have shown that heterozygosity for certain HLA-DR antigens confers a high risk of developing the disease. The HLA antigens of 75 Chinese patients and 100 Chinese controls in Hong Kong were studied to investigate the role of HLA-DR heterozygosity in Chinese individuals. Some of the patients and controls were also tested for allotypic variation in the complement components C2, C4, and BF. Three alleles, Aw33, B17, and DR3, had increased frequencies in patients compared with controls and frequently occurred together in the same phenotype, which suggested their existence as a haplotype. There were no statistically significant differences in complement allotype frequencies between patients and controls, although the C4B null allele seemed to be associated with Aw33, B17, and DR3. No other HLA-DR antigen appeared to be associated with IDDM. However, when the patients were separated on the basis of age at onset, the frequency of DR3/DRw9 heterozygosity was markedly increased in patients presenting in the first decade of life, but there was no increase in patients presenting at >20 yr of age. DRw9 is strongly associated with autoimmune disease in Chinese, whereas DR3 is not. We suggest that the major IDDM susceptibility locus in Chinese is associated with HLA-DR3 and that patients with HLA-DR3 and HLA-DRw9 have an added predisposition to autoimmune disease and therefore develop IDDM earlier than patients without DRw9.en_US
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_US
dc.relation.ispartofDiabetesen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshDiabetes Mellitus, Type 1 - Immunologyen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshHla Antigens - Analysis - Geneticsen_US
dc.subject.meshHla-D Antigens - Geneticsen_US
dc.subject.meshHla-Dr Antigens - Geneticsen_US
dc.subject.meshHla-Dr Serological Subtypesen_US
dc.subject.meshHla-Dr3 Antigenen_US
dc.subject.meshHeterozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshReference Valuesen_US
dc.titleStrong association of HLA-DR3/DRw9 heterozygosity with early-onset insulin-dependent diabetes mellitus in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.emailLow, LCK:lcklow@hkucc.hku.hken_US
dc.identifier.emailCheung, PT:ptcheung@hkucc.hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.identifier.authorityLow, LCK=rp00337en_US
dc.identifier.authorityCheung, PT=rp00351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2337/diabetes.36.11.1297-
dc.identifier.pmid3499357-
dc.identifier.scopuseid_2-s2.0-0023641076en_US
dc.identifier.volume36en_US
dc.identifier.issue11en_US
dc.identifier.spage1297en_US
dc.identifier.epage1300en_US
dc.identifier.isiWOS:A1987K677800014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHawkins, BR=35944486200en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridMa, JTC=24491943700en_US
dc.identifier.scopusauthoridLow, LCK=7007049461en_US
dc.identifier.scopusauthoridCheung, PT=7202595465en_US
dc.identifier.scopusauthoridSerjeantson, SW=7005404358en_US
dc.identifier.scopusauthoridYeung, RTT=7102833337en_US

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