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Article: Potential of glucan HBP-A in chondrocytes-alginate hydrogel constructs

TitlePotential of glucan HBP-A in chondrocytes-alginate hydrogel constructs
Authors
KeywordsCartilage
Chondrocyte
Glucan
Hydrogel Constructs
Type Ii Collagen
Issue Date2011
PublisherAcademic Journals. The Journal's web site is located at http://www.academicjournals.org/sre/
Citation
Scientific Research And Essays, 2011, v. 6 n. 6, p. 1364-1370 How to Cite?
AbstractTo explore the biological characteristics of an injectable chondrocytes-alginate hydrogel, constructs in the presence of glucan HBP-A as well as its role in cartilage tissue engineering, chondrocytes were isolated from rabbit knee cartilage and verified by immunocytochemistry for type II collagen. The constructs were embedded with HBP-A and then injected to nude mice subcutaneously. Six weeks after transplantaiton, the specimens were collected for Safranin O staining and transmission electron microscopy (TEM). The mRNA expressions of disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTs-5), aggrecan and type II collegan in constructs were determined by real time PCR. Newly generated cartilaginous tissue was found after transplantation, and the collagen was obvious in the HBP-A group. In accordance with morphological observations, the mRNA expression of type II collagen was also increased significantly, accompanied by decreased expression of ADAMTs-5 (P<0.05) in the HBP-A group compared with the control group. © 2011 Academic Journals.
Persistent Identifierhttp://hdl.handle.net/10722/170175
ISSN
2010 Impact Factor: 0.445
2014 SCImago Journal Rankings: 0.174
References

 

DC FieldValueLanguage
dc.contributor.authorCao, YLen_US
dc.contributor.authorPang, Jen_US
dc.contributor.authorZhan, HSen_US
dc.contributor.authorShi, YYen_US
dc.contributor.authorAbbah, SAen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorWang, SCen_US
dc.date.accessioned2012-10-30T06:05:50Z-
dc.date.available2012-10-30T06:05:50Z-
dc.date.issued2011en_US
dc.identifier.citationScientific Research And Essays, 2011, v. 6 n. 6, p. 1364-1370en_US
dc.identifier.issn1992-2248en_US
dc.identifier.urihttp://hdl.handle.net/10722/170175-
dc.description.abstractTo explore the biological characteristics of an injectable chondrocytes-alginate hydrogel, constructs in the presence of glucan HBP-A as well as its role in cartilage tissue engineering, chondrocytes were isolated from rabbit knee cartilage and verified by immunocytochemistry for type II collagen. The constructs were embedded with HBP-A and then injected to nude mice subcutaneously. Six weeks after transplantaiton, the specimens were collected for Safranin O staining and transmission electron microscopy (TEM). The mRNA expressions of disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTs-5), aggrecan and type II collegan in constructs were determined by real time PCR. Newly generated cartilaginous tissue was found after transplantation, and the collagen was obvious in the HBP-A group. In accordance with morphological observations, the mRNA expression of type II collagen was also increased significantly, accompanied by decreased expression of ADAMTs-5 (P<0.05) in the HBP-A group compared with the control group. © 2011 Academic Journals.en_US
dc.languageengen_US
dc.publisherAcademic Journals. The Journal's web site is located at http://www.academicjournals.org/sre/en_US
dc.relation.ispartofScientific Research and Essaysen_US
dc.subjectCartilageen_US
dc.subjectChondrocyteen_US
dc.subjectGlucanen_US
dc.subjectHydrogel Constructsen_US
dc.subjectType Ii Collagenen_US
dc.titlePotential of glucan HBP-A in chondrocytes-alginate hydrogel constructsen_US
dc.typeArticleen_US
dc.identifier.emailLu, WW:wwlu@hku.hken_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-79957643544en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957643544&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue6en_US
dc.identifier.spage1364en_US
dc.identifier.epage1370en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCao, YL=9036350500en_US
dc.identifier.scopusauthoridPang, J=7201733948en_US
dc.identifier.scopusauthoridZhan, HS=7102409198en_US
dc.identifier.scopusauthoridShi, YY=8275964800en_US
dc.identifier.scopusauthoridAbbah, SA=14032930600en_US
dc.identifier.scopusauthoridLu, WW=7404215221en_US
dc.identifier.scopusauthoridWang, X=54386136200en_US
dc.identifier.scopusauthoridWang, SC=54386338300en_US

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