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Article: Effects of calcitonin on the osseointegration of porous hydroxyapatite implant in osteoporosis model

TitleEffects of calcitonin on the osseointegration of porous hydroxyapatite implant in osteoporosis model
Authors
Issue Date2009
PublisherZhongguo Kangfu Yixuehui. The Journal's web site is located at http://www.zglckf.com/
Citation
Journal Of Clinical Rehabilitative Tissue Engineering Research, 2009, v. 13 n. 34, p. 6633-6636 How to Cite?
AbstractBACKGROUND: Calcitonin can increase bone quantity and quality and reduce bone fracture occurrence. OBJECTIVE: To evaluate effects of calcitonin on the osseointegration of the porous hydroxyapatite implants and further on promoting the biological fixation of the implants in osteoporosis model. DESIGN, TIME AND SETTING: A randomized controlled experiment was performed at the Animal Experimental Center of Sun Yat-sun University and Histomorphometry Laboratory of Hong Kong University from September to December 2007 and from March to May 2008, respectively. MATERIALS: A total of 30 female SD rats of SPF grade and aging 5 months were randomly divided into three groups: sham operation + hydroxyapatite, ovariectomy (OVX) + hydroxyapatite, and OVX + calcitonin + hydroxyapatite groups, with 10 rats per group. METHODS: Postmenopausal osteoporosis models were established in the OVX + hydroxyapatite and OVX + calcitonin + hydroxyapatite groups using OVX method. While, rats in the sham operation + hydroxyapatite group were considered as the controls. The porous hydroxyapatite prostheses were inserted into the tibial plateum of the left tibia in each group, followed by a subcutaneous injection of calcitonin [5 U/(kg·d)] for twelve weeks in the OVX + calcitonin + hydroxyapatite group. MAIN OUTCOME MEASURES: Tibia carrying with implant was sectioned into sections. Skeletal density changes of lumbar vertebra were detected using bone histomorphometry and double energy ray bone density apparatus, bone quantity surrounding prosthesis was observed, and osseointegration rate of prosthesis was measured. RESULTS: Bone density of lumbar vertebra was gradually improved in the OVX + calcitonin + hydroxyapatite group. After calcitonin injection, osseointegration area rate increased 22.0%, which was nearly twice compared with the OVX + hydroxyapatite group (t=9.665, P < 0.05). CONCLUSION: In osteoporosis conditions, calcitonin can increase bone mass surrounding the implants and promote osseointegration by subcutaneous injection.
Persistent Identifierhttp://hdl.handle.net/10722/170150
ISSN
2015 SCImago Journal Rankings: 0.107
References

 

DC FieldValueLanguage
dc.contributor.authorChen, BLen_US
dc.contributor.authorXie, DHen_US
dc.contributor.authorLü, WJen_US
dc.contributor.authorLi, FBen_US
dc.contributor.authorLiao, WMen_US
dc.contributor.authorLi, YQen_US
dc.date.accessioned2012-10-30T06:05:37Z-
dc.date.available2012-10-30T06:05:37Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Clinical Rehabilitative Tissue Engineering Research, 2009, v. 13 n. 34, p. 6633-6636en_US
dc.identifier.issn1673-8225en_US
dc.identifier.urihttp://hdl.handle.net/10722/170150-
dc.description.abstractBACKGROUND: Calcitonin can increase bone quantity and quality and reduce bone fracture occurrence. OBJECTIVE: To evaluate effects of calcitonin on the osseointegration of the porous hydroxyapatite implants and further on promoting the biological fixation of the implants in osteoporosis model. DESIGN, TIME AND SETTING: A randomized controlled experiment was performed at the Animal Experimental Center of Sun Yat-sun University and Histomorphometry Laboratory of Hong Kong University from September to December 2007 and from March to May 2008, respectively. MATERIALS: A total of 30 female SD rats of SPF grade and aging 5 months were randomly divided into three groups: sham operation + hydroxyapatite, ovariectomy (OVX) + hydroxyapatite, and OVX + calcitonin + hydroxyapatite groups, with 10 rats per group. METHODS: Postmenopausal osteoporosis models were established in the OVX + hydroxyapatite and OVX + calcitonin + hydroxyapatite groups using OVX method. While, rats in the sham operation + hydroxyapatite group were considered as the controls. The porous hydroxyapatite prostheses were inserted into the tibial plateum of the left tibia in each group, followed by a subcutaneous injection of calcitonin [5 U/(kg·d)] for twelve weeks in the OVX + calcitonin + hydroxyapatite group. MAIN OUTCOME MEASURES: Tibia carrying with implant was sectioned into sections. Skeletal density changes of lumbar vertebra were detected using bone histomorphometry and double energy ray bone density apparatus, bone quantity surrounding prosthesis was observed, and osseointegration rate of prosthesis was measured. RESULTS: Bone density of lumbar vertebra was gradually improved in the OVX + calcitonin + hydroxyapatite group. After calcitonin injection, osseointegration area rate increased 22.0%, which was nearly twice compared with the OVX + hydroxyapatite group (t=9.665, P < 0.05). CONCLUSION: In osteoporosis conditions, calcitonin can increase bone mass surrounding the implants and promote osseointegration by subcutaneous injection.en_US
dc.languageengen_US
dc.publisherZhongguo Kangfu Yixuehui. The Journal's web site is located at http://www.zglckf.com/en_US
dc.relation.ispartofJournal of Clinical Rehabilitative Tissue Engineering Researchen_US
dc.titleEffects of calcitonin on the osseointegration of porous hydroxyapatite implant in osteoporosis modelen_US
dc.typeArticleen_US
dc.identifier.emailLü, WJ:wwlu@hku.hken_US
dc.identifier.authorityLü, WJ=rp00411en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3969/j.issn.1673-8225.2009.34.006en_US
dc.identifier.scopuseid_2-s2.0-70350719290en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350719290&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue34en_US
dc.identifier.spage6633en_US
dc.identifier.epage6636en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridChen, BL=7408611442en_US
dc.identifier.scopusauthoridXie, DH=34874102700en_US
dc.identifier.scopusauthoridLü, WJ=7404215221en_US
dc.identifier.scopusauthoridLi, FB=8207335500en_US
dc.identifier.scopusauthoridLiao, WM=7203056975en_US
dc.identifier.scopusauthoridLi, YQ=36065283200en_US

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