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Article: Development of therapy for Duchenne muscular dystrophy.

TitleDevelopment of therapy for Duchenne muscular dystrophy.
Authors
Issue Date2007
Citation
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal Of Reparative And Reconstructive Surgery, 2007, v. 21 n. 2, p. 194-203 How to Cite?
AbstractOBJECTIVE: To review and summarize the latest development of the therapy for the Duchenne muscular dystrophy (DMD). METHODS: The recently-published articles related to the therapies for DMD were extensively reviewed and briefly summarized. RESULTS: The therapeutic approaches for DMD included the gene therapy, the cell therapy, and the pharmacological therapy. The gene therapy and the cell therapy were focused on the treatment for the cause of DMD by the delivery of the missing gene, the modification of the mutated gene, and the transfer of the normal cells including the stem cells, while the pharmacological therapy dealt with the downstream events caused by the dystrophin gene defect, slowed down the pathologic progress of DMD, and improved the DMD patient's life quality and life span, by medication and other factor treatments. CONCLUSION: There is still no cure for DMD because of various difficulties in replacing or repairing the defected gene and of the multifaceted nature of the severe symptoms. Therefore, it is imperative for us to find out a more effective treatment that can solve these problems.
Persistent Identifierhttp://hdl.handle.net/10722/170148
ISSN
2015 SCImago Journal Rankings: 0.128

 

DC FieldValueLanguage
dc.contributor.authorZhang, Sen_US
dc.contributor.authorXie, Hen_US
dc.contributor.authorZhou, Gen_US
dc.contributor.authorYang, Zen_US
dc.date.accessioned2012-10-30T06:05:37Z-
dc.date.available2012-10-30T06:05:37Z-
dc.date.issued2007en_US
dc.identifier.citationZhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal Of Reparative And Reconstructive Surgery, 2007, v. 21 n. 2, p. 194-203en_US
dc.identifier.issn1002-1892en_US
dc.identifier.urihttp://hdl.handle.net/10722/170148-
dc.description.abstractOBJECTIVE: To review and summarize the latest development of the therapy for the Duchenne muscular dystrophy (DMD). METHODS: The recently-published articles related to the therapies for DMD were extensively reviewed and briefly summarized. RESULTS: The therapeutic approaches for DMD included the gene therapy, the cell therapy, and the pharmacological therapy. The gene therapy and the cell therapy were focused on the treatment for the cause of DMD by the delivery of the missing gene, the modification of the mutated gene, and the transfer of the normal cells including the stem cells, while the pharmacological therapy dealt with the downstream events caused by the dystrophin gene defect, slowed down the pathologic progress of DMD, and improved the DMD patient's life quality and life span, by medication and other factor treatments. CONCLUSION: There is still no cure for DMD because of various difficulties in replacing or repairing the defected gene and of the multifaceted nature of the severe symptoms. Therefore, it is imperative for us to find out a more effective treatment that can solve these problems.en_US
dc.languageengen_US
dc.relation.ispartofZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgeryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Bacterial Agents - Therapeutic Useen_US
dc.subject.meshCell Transplantationen_US
dc.subject.meshDystrophin - Genetics - Metabolismen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshGene Therapy - Methodsen_US
dc.subject.meshGenetic Vectorsen_US
dc.subject.meshGentamicins - Therapeutic Useen_US
dc.subject.meshGlucocorticoids - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMuscle, Skeletal - Drug Effects - Metabolismen_US
dc.subject.meshMuscular Dystrophy, Duchenne - Genetics - Metabolism - Therapyen_US
dc.subject.meshMyoblasts - Transplantationen_US
dc.subject.meshOligonucleotides, Antisense - Therapeutic Useen_US
dc.subject.meshStem Cell Transplantationen_US
dc.titleDevelopment of therapy for Duchenne muscular dystrophy.en_US
dc.typeArticleen_US
dc.identifier.emailZhou, G:wormoscz@gmail.comen_US
dc.identifier.authorityZhou, G=rp00527en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17357471-
dc.identifier.scopuseid_2-s2.0-68549118971en_US
dc.identifier.volume21en_US
dc.identifier.issue2en_US
dc.identifier.spage194en_US
dc.identifier.epage203en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridZhang, S=7409377374en_US
dc.identifier.scopusauthoridXie, H=7401672194en_US
dc.identifier.scopusauthoridZhou, G=23394245100en_US
dc.identifier.scopusauthoridYang, Z=7405433260en_US

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