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Article: Histologic and electrophysiological changes of the paraspinal muscle after spinal fusion: An experimental study

TitleHistologic and electrophysiological changes of the paraspinal muscle after spinal fusion: An experimental study
Authors
KeywordsElectromyography
Muscle Atrophy
Muscle Fiber Size
Spinal Fusion
Issue Date2008
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.com
Citation
Spine, 2008, v. 33 n. 13, p. 1418-1422 How to Cite?
AbstractStudy design.: Experimental study evaluated electrophysiological and histologic changes in the paraspinal muscle after spinal fusion. Objective.: To determine the effect of posterior spinal fusion on paraspinal muscle by means of electrophysiological and histologic evaluation, using a rabbit model. Summary of background data.: Posterior lumbar spinal fusion is a common spinal surgery. Paraspinal muscular dysfunction is postulated to be due to injury inflicted by the surgery, either during exposure or from disuse of the fused segment. The effect of spinal fusion on paraspinal muscular function remains unclear. Methods.: Thirty New Zealand white rabbits were divided into 2 groups: 2-level posterior spinal fusion with instrumentation (group F) and the sham control group (group S). Preoperative and follow-up electromyography tests, as well as histologic assessments, were performed in 6-month intervals. Results.: In group F, 14 of 15 surgeries resulted in a solid fusion, as judged by postmortem examination. In group S, the root mean square of electromyography did not present a significant difference at 6-month follow-up when compared with preoperative status (P > 0.05). At 6-month follow-up, group F presented a significantly lower root mean square in the fused region than in adjacent regions (P < 0.05). Group S did not demonstrate significant differences in the median frequency between the preoperative and postoperative periods (P < 0.05). Group F resulted in a significant decrease of median frequency in the fusion region. However, increases were observed in the adjacent caudal region and the cranial region. The histologic analysis demonstrated a significant reduction in muscle fiber size (P < 0.05) in the fusion region of group F, when compared with the preoperative status, whereas group S did not present any significant differences (P > 0.05). Conclusion.: These results demonstrated that spinal fusion resulted in atrophy and reduced adjacent paraspinal muscle activity. Muscular activity was greater in the adjacent regions after spinal fusion, which may indicate muscle hypertrophy. © 2008, Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/170128
ISSN
2015 Impact Factor: 2.439
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHu, Yen_US
dc.contributor.authorLeung, HBen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorLuk, KDKen_US
dc.date.accessioned2012-10-30T06:05:28Z-
dc.date.available2012-10-30T06:05:28Z-
dc.date.issued2008en_US
dc.identifier.citationSpine, 2008, v. 33 n. 13, p. 1418-1422en_US
dc.identifier.issn0362-2436en_US
dc.identifier.urihttp://hdl.handle.net/10722/170128-
dc.description.abstractStudy design.: Experimental study evaluated electrophysiological and histologic changes in the paraspinal muscle after spinal fusion. Objective.: To determine the effect of posterior spinal fusion on paraspinal muscle by means of electrophysiological and histologic evaluation, using a rabbit model. Summary of background data.: Posterior lumbar spinal fusion is a common spinal surgery. Paraspinal muscular dysfunction is postulated to be due to injury inflicted by the surgery, either during exposure or from disuse of the fused segment. The effect of spinal fusion on paraspinal muscular function remains unclear. Methods.: Thirty New Zealand white rabbits were divided into 2 groups: 2-level posterior spinal fusion with instrumentation (group F) and the sham control group (group S). Preoperative and follow-up electromyography tests, as well as histologic assessments, were performed in 6-month intervals. Results.: In group F, 14 of 15 surgeries resulted in a solid fusion, as judged by postmortem examination. In group S, the root mean square of electromyography did not present a significant difference at 6-month follow-up when compared with preoperative status (P > 0.05). At 6-month follow-up, group F presented a significantly lower root mean square in the fused region than in adjacent regions (P < 0.05). Group S did not demonstrate significant differences in the median frequency between the preoperative and postoperative periods (P < 0.05). Group F resulted in a significant decrease of median frequency in the fusion region. However, increases were observed in the adjacent caudal region and the cranial region. The histologic analysis demonstrated a significant reduction in muscle fiber size (P < 0.05) in the fusion region of group F, when compared with the preoperative status, whereas group S did not present any significant differences (P > 0.05). Conclusion.: These results demonstrated that spinal fusion resulted in atrophy and reduced adjacent paraspinal muscle activity. Muscular activity was greater in the adjacent regions after spinal fusion, which may indicate muscle hypertrophy. © 2008, Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.comen_US
dc.relation.ispartofSpineen_US
dc.subjectElectromyographyen_US
dc.subjectMuscle Atrophyen_US
dc.subjectMuscle Fiber Sizeen_US
dc.subjectSpinal Fusionen_US
dc.titleHistologic and electrophysiological changes of the paraspinal muscle after spinal fusion: An experimental studyen_US
dc.typeArticleen_US
dc.identifier.emailHu, Y:yhud@hku.hken_US
dc.identifier.emailLu, WW:wwlu@hku.hken_US
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_US
dc.identifier.authorityHu, Y=rp00432en_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/BRS.0b013e3181753beaen_US
dc.identifier.pmid18520936-
dc.identifier.scopuseid_2-s2.0-46749150080en_US
dc.identifier.hkuros142798-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46749150080&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue13en_US
dc.identifier.spage1418en_US
dc.identifier.epage1422en_US
dc.identifier.isiWOS:000256433100004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHu, Y=7407116091en_US
dc.identifier.scopusauthoridLeung, HB=30967606800en_US
dc.identifier.scopusauthoridLu, WW=7404215221en_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US

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