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Article: Preparation and cell-materials interactions of plasma sprayed strontium-containing hydroxyapatite coating

TitlePreparation and cell-materials interactions of plasma sprayed strontium-containing hydroxyapatite coating
Authors
KeywordsBioactivity
Hydroxyapatite Coating
Osteoblast
Plasma Spraying
Strontium
Issue Date2007
PublisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/surfcoat
Citation
Surface And Coatings Technology, 2007, v. 201 n. 8, p. 4685-4693 How to Cite?
AbstractThe use of strontium-containing hydroxyapatite (Sr-HA) as a biomaterial has been reported recently. In vitro and in vivo studies have shown that Sr-HA promotes osteoblast response and stimulates new bone formation. In order to extend its usage to major load-bearing applications, such as artificial hip replacement, it has been proposed that the material could be used in the form of a coating on implant surfaces. This paper reports a preliminary study of biocompatibility of plasma sprayed Sr-HA coatings on a metallic substrate. Coatings of Sr-HA containing 10 mol% Sr2+ was produced on titanium alloy substrates. The coating exhibited good bonding with the substrate. The bioactivity of Sr-HA coating was evaluated in vitro by immersion in simulated body fluid (SBF). After immersion in SBF, Sr-HA coating exhibited great ability to induce apatite precipitation on its surface. The possible effects of cell-materials interactions of Sr-HA coating were examined by culturing osteoprecursor cells (OPC1) on coating surfaces. The effect of Sr-HA was also compared to a hydroxyapatite (HA) coating, which is widely used in orthopedics and dentistry. The results indicated that Sr-HA coating had good biocompatibility with human osteoblasts. OPC1 cells survived and proliferated well on the surface of coating. Sr-HA coating promoted OPC1 cells attachment, and more local contacts were produced on the surface. The presence of Sr stimulated OPC1 cell differentiation and ALP expression. No deleterious effect on ECM formation and mineralization was found with Sr-HA coating. The results indicated that Sr-HA coating had good mechanical properties and bioactivity in vitro. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170095
ISSN
2015 Impact Factor: 2.139
2015 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXue, Wen_US
dc.contributor.authorHosick, HLen_US
dc.contributor.authorBandyopadhyay, Aen_US
dc.contributor.authorBose, Sen_US
dc.contributor.authorDing, Cen_US
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorCheung, KMCen_US
dc.contributor.authorLu, WWen_US
dc.date.accessioned2012-10-30T06:05:16Z-
dc.date.available2012-10-30T06:05:16Z-
dc.date.issued2007en_US
dc.identifier.citationSurface And Coatings Technology, 2007, v. 201 n. 8, p. 4685-4693en_US
dc.identifier.issn0257-8972en_US
dc.identifier.urihttp://hdl.handle.net/10722/170095-
dc.description.abstractThe use of strontium-containing hydroxyapatite (Sr-HA) as a biomaterial has been reported recently. In vitro and in vivo studies have shown that Sr-HA promotes osteoblast response and stimulates new bone formation. In order to extend its usage to major load-bearing applications, such as artificial hip replacement, it has been proposed that the material could be used in the form of a coating on implant surfaces. This paper reports a preliminary study of biocompatibility of plasma sprayed Sr-HA coatings on a metallic substrate. Coatings of Sr-HA containing 10 mol% Sr2+ was produced on titanium alloy substrates. The coating exhibited good bonding with the substrate. The bioactivity of Sr-HA coating was evaluated in vitro by immersion in simulated body fluid (SBF). After immersion in SBF, Sr-HA coating exhibited great ability to induce apatite precipitation on its surface. The possible effects of cell-materials interactions of Sr-HA coating were examined by culturing osteoprecursor cells (OPC1) on coating surfaces. The effect of Sr-HA was also compared to a hydroxyapatite (HA) coating, which is widely used in orthopedics and dentistry. The results indicated that Sr-HA coating had good biocompatibility with human osteoblasts. OPC1 cells survived and proliferated well on the surface of coating. Sr-HA coating promoted OPC1 cells attachment, and more local contacts were produced on the surface. The presence of Sr stimulated OPC1 cell differentiation and ALP expression. No deleterious effect on ECM formation and mineralization was found with Sr-HA coating. The results indicated that Sr-HA coating had good mechanical properties and bioactivity in vitro. © 2006 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/surfcoaten_US
dc.relation.ispartofSurface and Coatings Technologyen_US
dc.subjectBioactivityen_US
dc.subjectHydroxyapatite Coatingen_US
dc.subjectOsteoblasten_US
dc.subjectPlasma Sprayingen_US
dc.subjectStrontiumen_US
dc.titlePreparation and cell-materials interactions of plasma sprayed strontium-containing hydroxyapatite coatingen_US
dc.typeArticleen_US
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_US
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_US
dc.identifier.emailLu, WW:wwlu@hku.hken_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.identifier.authorityCheung, KMC=rp00387en_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.surfcoat.2006.10.012en_US
dc.identifier.scopuseid_2-s2.0-33845285838en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845285838&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume201en_US
dc.identifier.issue8en_US
dc.identifier.spage4685en_US
dc.identifier.epage4693en_US
dc.identifier.isiWOS:000243655900026-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridXue, W=7103165239en_US
dc.identifier.scopusauthoridHosick, HL=7004832024en_US
dc.identifier.scopusauthoridBandyopadhyay, A=35582612800en_US
dc.identifier.scopusauthoridBose, S=7401626559en_US
dc.identifier.scopusauthoridDing, C=7202621988en_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US
dc.identifier.scopusauthoridCheung, KMC=7402406754en_US
dc.identifier.scopusauthoridLu, WW=7404215221en_US

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