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Article: A rapid temperature-responsive sol-gel reversible poly(N- isopropylacrylamide)-g-methylcellulose copolymer hydrogel

TitleA rapid temperature-responsive sol-gel reversible poly(N- isopropylacrylamide)-g-methylcellulose copolymer hydrogel
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2004, v. 25 n. 15, p. 3005-3012 How to Cite?
AbstractPoly(N-isopropylacrylamide) (PNIPAAm) was grafted to methylcellulose (MC) with various feeding ratios using ammonium persulfate and N,N,N′,N′- tetramethyl ethylene diamine as an initiator. FTIR results confirm the formation of PNIPAAm-g-MC copolymers. The temperature responsiveness of copolymer gels was investigated by turbidimetry, dynamic contact angle (DCA), differential scanning calorimetry and dynamic mechanical analysis (DMA). The results indicate that PNIPAAm-g-MC hydrogels are strongly temperature responsive. At lower contents of MC, the lower critical solution temperature (LCST) is decreased, whereas further increasing MC contents raises the LCSTs. It is observed that the phase transition of the hydrogels occurs reversibly within 1min, and near body temperature, a rigid gel can be generated in a certain range of MC content. What is more, the incorporation of MC prevents the syneresis of copolymer hydrogel. DMA measurement reveals that the storage moduli (E′) of the gels increase upon increasing MC contents, and moreover the values of E′ go up markedly above LCST. The copolymer hydrogels hold a promise as a blood vessel barrier by tuning gelation temperature, gelation time and mechanical strength. © 2003 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170060
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Wen_US
dc.contributor.authorZhang, Ben_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorZhu, Den_US
dc.contributor.authorYao, KDen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorZhao, Cen_US
dc.contributor.authorWang, Cen_US
dc.date.accessioned2012-10-30T06:05:04Z-
dc.date.available2012-10-30T06:05:04Z-
dc.date.issued2004en_US
dc.identifier.citationBiomaterials, 2004, v. 25 n. 15, p. 3005-3012en_US
dc.identifier.issn0142-9612en_US
dc.identifier.urihttp://hdl.handle.net/10722/170060-
dc.description.abstractPoly(N-isopropylacrylamide) (PNIPAAm) was grafted to methylcellulose (MC) with various feeding ratios using ammonium persulfate and N,N,N′,N′- tetramethyl ethylene diamine as an initiator. FTIR results confirm the formation of PNIPAAm-g-MC copolymers. The temperature responsiveness of copolymer gels was investigated by turbidimetry, dynamic contact angle (DCA), differential scanning calorimetry and dynamic mechanical analysis (DMA). The results indicate that PNIPAAm-g-MC hydrogels are strongly temperature responsive. At lower contents of MC, the lower critical solution temperature (LCST) is decreased, whereas further increasing MC contents raises the LCSTs. It is observed that the phase transition of the hydrogels occurs reversibly within 1min, and near body temperature, a rigid gel can be generated in a certain range of MC content. What is more, the incorporation of MC prevents the syneresis of copolymer hydrogel. DMA measurement reveals that the storage moduli (E′) of the gels increase upon increasing MC contents, and moreover the values of E′ go up markedly above LCST. The copolymer hydrogels hold a promise as a blood vessel barrier by tuning gelation temperature, gelation time and mechanical strength. © 2003 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_US
dc.relation.ispartofBiomaterialsen_US
dc.subject.meshAcrylic Resins - Chemistryen_US
dc.subject.meshBiocompatible Materials - Chemistryen_US
dc.subject.meshElasticityen_US
dc.subject.meshHot Temperatureen_US
dc.subject.meshHydrogels - Chemistryen_US
dc.subject.meshMacromolecular Substancesen_US
dc.subject.meshMaterials Testingen_US
dc.subject.meshMethylcellulose - Chemistryen_US
dc.subject.meshMolecular Conformationen_US
dc.subject.meshPhase Transitionen_US
dc.subject.meshPolymersen_US
dc.subject.meshSurface Propertiesen_US
dc.subject.meshTemperatureen_US
dc.subject.meshTransition Temperatureen_US
dc.subject.meshViscosityen_US
dc.titleA rapid temperature-responsive sol-gel reversible poly(N- isopropylacrylamide)-g-methylcellulose copolymer hydrogelen_US
dc.typeArticleen_US
dc.identifier.emailLu, WW:wwlu@hku.hken_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biomaterials.2003.09.077en_US
dc.identifier.pmid14967533-
dc.identifier.scopuseid_2-s2.0-1142309722en_US
dc.identifier.hkuros87294-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1142309722&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue15en_US
dc.identifier.spage3005en_US
dc.identifier.epage3012en_US
dc.identifier.isiWOS:000189221600012-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLiu, W=7408473555en_US
dc.identifier.scopusauthoridZhang, B=8512129100en_US
dc.identifier.scopusauthoridLu, WW=7404215221en_US
dc.identifier.scopusauthoridLi, X=15219864000en_US
dc.identifier.scopusauthoridZhu, D=7403598606en_US
dc.identifier.scopusauthoridYao, KD=7403234424en_US
dc.identifier.scopusauthoridWang, Q=8841951000en_US
dc.identifier.scopusauthoridZhao, C=12142770900en_US
dc.identifier.scopusauthoridWang, C=12799878700en_US

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