File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A novel injectable bioactive bone cement for spinal surgery: A developmental and preclinical study

TitleA novel injectable bioactive bone cement for spinal surgery: A developmental and preclinical study
Authors
KeywordsBioactive bone cement
Biocompatibility
Biomechanics
Spinal surgery
Strontium-containing hydroxyapatite
Issue Date2000
Citation
Journal Of Biomedical Materials Research, 2000, v. 52 n. 1, p. 164-170 How to Cite?
AbstractThe injection of bone cement by minimally invasive techniques for the treatment of vertebral body fractures or for stabilization of an osteoporotic vertebral body is regarded as promising in spinal surgery. The purpose of this study was to develop a novel injectable bioactive bone cement to address such concerns. The cement was composed mainly of strontium-containing hydroxyapatite (Sr-HA) filler and Bisphenol A Diglycidylether Dimethacrylate (DGMA) resin. The Sr-HA filler was prepared by precipitation and calcination, then analyzed with Fourier transform infra-red (FTIR) spectra and X-ray diffraction (XRD) patterns. Samples of strontium-containing hydroxyapatite cement (SrHAC) were formed by a combination of powder filler and resin matrix, with the setting time and peak temperature recorded. Cell relative growth rate (RGR), Tetrazolium bromide (MTT), and haemolysis tests were used to detect initial in vitro biocompatibility of the new cement. In vitro spinal biomechanical testing and morphological observation after bone cement injection were performed on pig spines. Results indicate that the setting time and peak temperature of the cement was 15 min and 55°C, respectively. Cytotoxicity of the cement was class 1 (no cytotoxicity) and haemolysis was 1% (no haemolysis). Stiffness after cement injection and fatigue loading were 112% and 95% of the intact bone, respectively, which is similar to that of natural bone. Radiopacity of SrHAC allowed easy radiographic imaging. The use of SrHAC cement is, thus, promising in spinal surgery. (C) 2000 John Wiley and Sons, Inc. | The injection of bone cement by minimally invasive techniques for the treatment of vertebral body fractures or for stabilization of an osteoporotic vertebral body is regarded as promising in spinal surgery. The purpose of this study was to develop a novel injectable bioactive bone cement to address such concerns. The cement was composed mainly of strontium-containing hydroxyapatite (Sr-HA) filler and Bisphenol A Diglycidylether Dimethacrylate (DGMA) resin. The Sr-HA filler was prepared by precipitation and calcination, then analyzed with Fourier transform infrared (FTIR) spectra and X-ray diffraction (XRD) patterns. Samples of strontium-containing hydroxyapatite cement (SrHAC) were formed by a combination of powder filler and resin matrix, with the setting time and peak temperature recorded. Cell relative growth rate (RGR), Tetrazolium bromide (MTT), and haemolysis tests were used to detect initial in vitro biocompatibility of the new cement. In vitro spinal biomechanical testing and morphological observation after bone cement injection were performed on pig spines. Results indicate that the setting time and peak temperature of the cement was 15 min and 55°C, respectively. Cytotoxicity of the cement was class 1 (no cytotoxicity) and haemolysis was 1% (no haemolysis). Stiffness after cement injection and fatigue loading were 112% and 95% of the intact bone, respectively, which is similar to that of natural bone. Radiopacity of SrHAC allowed easy radiographic imaging. The use of SrHAC cement is, thus, promising in spinal surgery.
Persistent Identifierhttp://hdl.handle.net/10722/170027
ISSN
2004 Impact Factor: 3.652
2006 SCImago Journal Rankings: 0.474
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, YWen_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorChiu, KYen_HK
dc.contributor.authorChow, SPen_HK
dc.date.accessioned2012-10-30T06:04:50Z-
dc.date.available2012-10-30T06:04:50Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Biomedical Materials Research, 2000, v. 52 n. 1, p. 164-170en_HK
dc.identifier.issn0021-9304en_HK
dc.identifier.urihttp://hdl.handle.net/10722/170027-
dc.description.abstractThe injection of bone cement by minimally invasive techniques for the treatment of vertebral body fractures or for stabilization of an osteoporotic vertebral body is regarded as promising in spinal surgery. The purpose of this study was to develop a novel injectable bioactive bone cement to address such concerns. The cement was composed mainly of strontium-containing hydroxyapatite (Sr-HA) filler and Bisphenol A Diglycidylether Dimethacrylate (DGMA) resin. The Sr-HA filler was prepared by precipitation and calcination, then analyzed with Fourier transform infra-red (FTIR) spectra and X-ray diffraction (XRD) patterns. Samples of strontium-containing hydroxyapatite cement (SrHAC) were formed by a combination of powder filler and resin matrix, with the setting time and peak temperature recorded. Cell relative growth rate (RGR), Tetrazolium bromide (MTT), and haemolysis tests were used to detect initial in vitro biocompatibility of the new cement. In vitro spinal biomechanical testing and morphological observation after bone cement injection were performed on pig spines. Results indicate that the setting time and peak temperature of the cement was 15 min and 55°C, respectively. Cytotoxicity of the cement was class 1 (no cytotoxicity) and haemolysis was 1% (no haemolysis). Stiffness after cement injection and fatigue loading were 112% and 95% of the intact bone, respectively, which is similar to that of natural bone. Radiopacity of SrHAC allowed easy radiographic imaging. The use of SrHAC cement is, thus, promising in spinal surgery. (C) 2000 John Wiley and Sons, Inc. | The injection of bone cement by minimally invasive techniques for the treatment of vertebral body fractures or for stabilization of an osteoporotic vertebral body is regarded as promising in spinal surgery. The purpose of this study was to develop a novel injectable bioactive bone cement to address such concerns. The cement was composed mainly of strontium-containing hydroxyapatite (Sr-HA) filler and Bisphenol A Diglycidylether Dimethacrylate (DGMA) resin. The Sr-HA filler was prepared by precipitation and calcination, then analyzed with Fourier transform infrared (FTIR) spectra and X-ray diffraction (XRD) patterns. Samples of strontium-containing hydroxyapatite cement (SrHAC) were formed by a combination of powder filler and resin matrix, with the setting time and peak temperature recorded. Cell relative growth rate (RGR), Tetrazolium bromide (MTT), and haemolysis tests were used to detect initial in vitro biocompatibility of the new cement. In vitro spinal biomechanical testing and morphological observation after bone cement injection were performed on pig spines. Results indicate that the setting time and peak temperature of the cement was 15 min and 55°C, respectively. Cytotoxicity of the cement was class 1 (no cytotoxicity) and haemolysis was 1% (no haemolysis). Stiffness after cement injection and fatigue loading were 112% and 95% of the intact bone, respectively, which is similar to that of natural bone. Radiopacity of SrHAC allowed easy radiographic imaging. The use of SrHAC cement is, thus, promising in spinal surgery.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of Biomedical Materials Researchen_HK
dc.rightsJournal of Biomedical Materials Research Part A. Copyright © John Wiley & Sons, Inc.-
dc.subjectBioactive bone cementen_HK
dc.subjectBiocompatibilityen_HK
dc.subjectBiomechanicsen_HK
dc.subjectSpinal surgeryen_HK
dc.subjectStrontium-containing hydroxyapatiteen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBone Cementsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshHumansen_US
dc.subject.meshHydroxyapatitesen_US
dc.subject.meshMiceen_US
dc.subject.meshSpine - Surgeryen_US
dc.subject.meshStrontiumen_US
dc.titleA novel injectable bioactive bone cement for spinal surgery: A developmental and preclinical studyen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailChiu, KY: pkychiu@hkucc.hku.hken_HK
dc.identifier.emailChow, SP: spchow@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.identifier.authorityChow, SP=rp00064en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-4636(200010)52:1<164::AID-JBM21>3.0.CO;2-R-
dc.identifier.pmid10906688-
dc.identifier.scopuseid_2-s2.0-0034255813en_HK
dc.identifier.hkuros50182-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034255813&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue1en_HK
dc.identifier.spage164en_HK
dc.identifier.epage170en_HK
dc.identifier.isiWOS:000088369000021-
dc.identifier.scopusauthoridLi, YW=7502084099en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK
dc.identifier.scopusauthoridChow, SP=7201828376en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats