Article: ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium

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Title	ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium
Authors	Leung, KW1 Gvritishvili, A1 Liu, Y1 TombranTink, J1
Keywords	Age-related macular degeneration Aging Retina RPE cells Zinc transport Zinc transporters
Issue Date	2012
Citation	Journal Of Molecular Neuroscience, 2012, v. 46 n. 2, p. 122-137 [How to Cite?] DOI: http://dx.doi.org/10.1007/s12031-011-9536-0
Abstract	Decreases in systemic and cellular levels of zinc (Zn 2+) during normal aging correlate with several age-related pathologies including age-related macular degeneration. Zn 2+ homeostasis in tissues is not only dependent on dietary intake but also on optimal expression and function of its influx (ZIP) and efflux (ZnT) transporters. We recently showed that many of the Zn 2+ transporters are expressed by the retinal pigment epithelial (RPE) cells. In this study, we present evidence that RPE cells contain less endogenous Zn 2+ with increased aging and transport this ion vectorially with greater transport from the basal to apical direction. Expression of two Zn 2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of RPE age. Gene silencing of ZIP2 and ZIP4 in RPE cells from young donors or their overexpression in cells from older donors confirms that these two transporters are essential in controlling Zn 2+ influx and sequestration in RPE cells. Both transporters are distributed on the basal surface of the RPE where they are likely to control Zn 2+ homeostasis in the outer retina. © Springer Science+Business Media, LLC 2011.
ISSN	0895-8696 2011 Impact Factor: 2.504 2011 SCImago Journal Rankings: 0.221
DOI	http://dx.doi.org/10.1007/s12031-011-9536-0
References	References in Scopus

DC Field	Value
dc.contributor.author	Leung, KW
dc.contributor.author	Gvritishvili, A
dc.contributor.author	Liu, Y
dc.contributor.author	TombranTink, J
dc.date.accessioned	2012-10-25T04:57:11Z
dc.date.available	2012-10-25T04:57:11Z
dc.date.issued	2012
dc.description.abstract	Decreases in systemic and cellular levels of zinc (Zn 2+) during normal aging correlate with several age-related pathologies including age-related macular degeneration. Zn 2+ homeostasis in tissues is not only dependent on dietary intake but also on optimal expression and function of its influx (ZIP) and efflux (ZnT) transporters. We recently showed that many of the Zn 2+ transporters are expressed by the retinal pigment epithelial (RPE) cells. In this study, we present evidence that RPE cells contain less endogenous Zn 2+ with increased aging and transport this ion vectorially with greater transport from the basal to apical direction. Expression of two Zn 2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of RPE age. Gene silencing of ZIP2 and ZIP4 in RPE cells from young donors or their overexpression in cells from older donors confirms that these two transporters are essential in controlling Zn 2+ influx and sequestration in RPE cells. Both transporters are distributed on the basal surface of the RPE where they are likely to control Zn 2+ homeostasis in the outer retina. © Springer Science+Business Media, LLC 2011.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Journal Of Molecular Neuroscience, 2012, v. 46 n. 2, p. 122-137 [How to Cite?] DOI: http://dx.doi.org/10.1007/s12031-011-9536-0
dc.identifier.citeulike	9363874
dc.identifier.doi	http://dx.doi.org/10.1007/s12031-011-9536-0
dc.identifier.epage	137
dc.identifier.issn	0895-8696 2011 Impact Factor: 2.504 2011 SCImago Journal Rankings: 0.221
dc.identifier.issue	2
dc.identifier.scopus	eid_2-s2.0-84863385420
dc.identifier.spage	122
dc.identifier.uri	http://hdl.handle.net/10722/169868
dc.identifier.volume	46
dc.language	eng
dc.publisher.place	United States
dc.relation.ispartof	Journal of Molecular Neuroscience
dc.relation.references	References in Scopus
dc.subject	Age-related macular degeneration
dc.subject	Aging
dc.subject	Retina
dc.subject	RPE cells
dc.subject	Zinc transport
dc.subject	Zinc transporters
dc.title	ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium
dc.type	Article

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Penn State College of Medicine

Article: ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium

The HKU Scholars Hub has contact details for these author(s).