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Article: ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium

TitleZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium
Authors
KeywordsAge-related macular degeneration
Aging
Retina
RPE cells
Zinc transport
Zinc transporters
Issue Date2012
Citation
Journal Of Molecular Neuroscience, 2012, v. 46 n. 2, p. 122-137 How to Cite?
Abstract
Decreases in systemic and cellular levels of zinc (Zn 2+) during normal aging correlate with several age-related pathologies including age-related macular degeneration. Zn 2+ homeostasis in tissues is not only dependent on dietary intake but also on optimal expression and function of its influx (ZIP) and efflux (ZnT) transporters. We recently showed that many of the Zn 2+ transporters are expressed by the retinal pigment epithelial (RPE) cells. In this study, we present evidence that RPE cells contain less endogenous Zn 2+ with increased aging and transport this ion vectorially with greater transport from the basal to apical direction. Expression of two Zn 2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of RPE age. Gene silencing of ZIP2 and ZIP4 in RPE cells from young donors or their overexpression in cells from older donors confirms that these two transporters are essential in controlling Zn 2+ influx and sequestration in RPE cells. Both transporters are distributed on the basal surface of the RPE where they are likely to control Zn 2+ homeostasis in the outer retina. © Springer Science+Business Media, LLC 2011.
Persistent Identifierhttp://hdl.handle.net/10722/169868
ISSN
2013 Impact Factor: 2.757
2013 SCImago Journal Rankings: 1.242
ISI Accession Number ID
References

 

Author Affiliations
  1. Penn State College of Medicine
DC FieldValueLanguage
dc.contributor.authorLeung, KWen_HK
dc.contributor.authorGvritishvili, Aen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorTombranTink, Jen_HK
dc.date.accessioned2012-10-25T04:57:11Z-
dc.date.available2012-10-25T04:57:11Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Molecular Neuroscience, 2012, v. 46 n. 2, p. 122-137en_HK
dc.identifier.issn0895-8696en_HK
dc.identifier.urihttp://hdl.handle.net/10722/169868-
dc.description.abstractDecreases in systemic and cellular levels of zinc (Zn 2+) during normal aging correlate with several age-related pathologies including age-related macular degeneration. Zn 2+ homeostasis in tissues is not only dependent on dietary intake but also on optimal expression and function of its influx (ZIP) and efflux (ZnT) transporters. We recently showed that many of the Zn 2+ transporters are expressed by the retinal pigment epithelial (RPE) cells. In this study, we present evidence that RPE cells contain less endogenous Zn 2+ with increased aging and transport this ion vectorially with greater transport from the basal to apical direction. Expression of two Zn 2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of RPE age. Gene silencing of ZIP2 and ZIP4 in RPE cells from young donors or their overexpression in cells from older donors confirms that these two transporters are essential in controlling Zn 2+ influx and sequestration in RPE cells. Both transporters are distributed on the basal surface of the RPE where they are likely to control Zn 2+ homeostasis in the outer retina. © Springer Science+Business Media, LLC 2011.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of Molecular Neuroscienceen_HK
dc.subjectAge-related macular degenerationen_HK
dc.subjectAgingen_HK
dc.subjectRetinaen_HK
dc.subjectRPE cellsen_HK
dc.subjectZinc transporten_HK
dc.subjectZinc transportersen_HK
dc.titleZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epitheliumen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, KW: kwleung1@hku.hken_HK
dc.identifier.authorityLeung, KW=rp01674en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s12031-011-9536-0en_HK
dc.identifier.pmid21603979-
dc.identifier.scopuseid_2-s2.0-84863385420en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858862045&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue2en_HK
dc.identifier.spage122en_HK
dc.identifier.epage137en_HK
dc.identifier.isiWOS:000299332200013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, KW=13106059300en_HK
dc.identifier.scopusauthoridGvritishvili, A=15834526600en_HK
dc.identifier.scopusauthoridLiu, Y=37561642700en_HK
dc.identifier.scopusauthoridTombranTink, J=7003724753en_HK
dc.identifier.citeulike9363874-

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