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Article: Functional performance and quality of life in patients with squamous esophageal carcinoma receiving surgery or chemoradiation: Results from a randomized trial

TitleFunctional performance and quality of life in patients with squamous esophageal carcinoma receiving surgery or chemoradiation: Results from a randomized trial
Authors
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
Citation
Annals Of Surgery, 2011, v. 253 n. 1, p. 1-5 How to Cite?
AbstractObjective: The aim of this study was to compare the 2-year functional performance and quality of life in patients with operable squamous cell carcinoma of the esophagus, who have received either surgery or definitive chemoradiation (CRT). Summary Background Data: The functional outcomes and quality of life in patients receiving esophagectomy or definitive CRT is uncertain. Methods: Data were extracted from the database of a prospective randomized controlled trial that included patients with resectable mid or lower thoracic esophageal cancers. The patients were randomized to either standard esophagectomy or definitive CRT. Quality of life assessments were performed using the EORTC QLQ-C30 and QLQ-OES24 modules. Other functional assessments included pulmonary and eating functions. Results: From July 2000 to December 2004, a total of 81 patients were enrolled into the study. No significant longitudinal changes were detected in the global health status in both groups upon available follow-up. Surgery was associated with worsened physical functioning and fatigue symptoms up to 6 months after treatment (P < 0.001 and P = 0.021, respectively) and these scales improved at 2 years. In terms of pulmonary function, dyspnoic and coughing symptoms were significantly worsened 3 months after surgery (P = 0.024 and P = 0.036, respectively) whereas symptoms in the CRT group progressively deteriorated over time. Concerning the eating function, both groups had improvements in dysphagia but there were frequent need for endoscopic intervention. This study has been registered with clinicaltrials.gov and the clinicaltrials.gov ID number is NCT01032967. Conclusion: Neither surgery nor definitive CRT significantly impaired the global health status of patients. Surgery was associated with a short-term negative impact in some aspects of health related quality of life assessments but these changes became insignificant 2 years after treatment. However, CRT was associated with progressive deteriorations in pulmonary function in the longer term. © 2010 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/169751
ISSN
2015 Impact Factor: 8.569
2015 SCImago Journal Rankings: 4.503
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTeoh, AYBen_US
dc.contributor.authorYan Chiu, PWen_US
dc.contributor.authorWong, TCLen_US
dc.contributor.authorLiu, SYWen_US
dc.contributor.authorHung Wong, SKen_US
dc.contributor.authorNg, EKWen_US
dc.date.accessioned2012-10-25T04:54:50Z-
dc.date.available2012-10-25T04:54:50Z-
dc.date.issued2011en_US
dc.identifier.citationAnnals Of Surgery, 2011, v. 253 n. 1, p. 1-5en_US
dc.identifier.issn0003-4932en_US
dc.identifier.urihttp://hdl.handle.net/10722/169751-
dc.description.abstractObjective: The aim of this study was to compare the 2-year functional performance and quality of life in patients with operable squamous cell carcinoma of the esophagus, who have received either surgery or definitive chemoradiation (CRT). Summary Background Data: The functional outcomes and quality of life in patients receiving esophagectomy or definitive CRT is uncertain. Methods: Data were extracted from the database of a prospective randomized controlled trial that included patients with resectable mid or lower thoracic esophageal cancers. The patients were randomized to either standard esophagectomy or definitive CRT. Quality of life assessments were performed using the EORTC QLQ-C30 and QLQ-OES24 modules. Other functional assessments included pulmonary and eating functions. Results: From July 2000 to December 2004, a total of 81 patients were enrolled into the study. No significant longitudinal changes were detected in the global health status in both groups upon available follow-up. Surgery was associated with worsened physical functioning and fatigue symptoms up to 6 months after treatment (P < 0.001 and P = 0.021, respectively) and these scales improved at 2 years. In terms of pulmonary function, dyspnoic and coughing symptoms were significantly worsened 3 months after surgery (P = 0.024 and P = 0.036, respectively) whereas symptoms in the CRT group progressively deteriorated over time. Concerning the eating function, both groups had improvements in dysphagia but there were frequent need for endoscopic intervention. This study has been registered with clinicaltrials.gov and the clinicaltrials.gov ID number is NCT01032967. Conclusion: Neither surgery nor definitive CRT significantly impaired the global health status of patients. Surgery was associated with a short-term negative impact in some aspects of health related quality of life assessments but these changes became insignificant 2 years after treatment. However, CRT was associated with progressive deteriorations in pulmonary function in the longer term. © 2010 Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.comen_US
dc.relation.ispartofAnnals of Surgeryen_US
dc.subject.meshCarcinoma, Squamous Cell - Physiopathology - Therapyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshDeglutitionen_US
dc.subject.meshEsophageal Neoplasms - Physiopathology - Therapyen_US
dc.subject.meshEsophagectomyen_US
dc.subject.meshHumansen_US
dc.subject.meshQuality Of Lifeen_US
dc.subject.meshRecovery Of Functionen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleFunctional performance and quality of life in patients with squamous esophageal carcinoma receiving surgery or chemoradiation: Results from a randomized trialen_US
dc.typeArticleen_US
dc.identifier.emailWong, TCL: wongtcl@hku.hken_US
dc.identifier.authorityWong, TCL=rp01679en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/SLA.0b013e3181fcd991en_US
dc.identifier.pmid21233603-
dc.identifier.scopuseid_2-s2.0-78751637563en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78751637563&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume253en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage5en_US
dc.identifier.isiWOS:000286179100001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTeoh, AYB=6602494653en_US
dc.identifier.scopusauthoridYan Chiu, PW=15077732600en_US
dc.identifier.scopusauthoridWong, TCL=22977955100en_US
dc.identifier.scopusauthoridLiu, SYW=35793951100en_US
dc.identifier.scopusauthoridHung Wong, SK=36815989400en_US
dc.identifier.scopusauthoridNg, EKW=24328695100en_US

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