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Article: BMP4 signaling mediates Zeb family in developing mouse tooth

TitleBMP4 signaling mediates Zeb family in developing mouse tooth
Authors
Issue Date2012
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00418/index.htm
Citation
Histochemistry And Cell Biology, 2012, v. 137 n. 6, p. 791-800 How to Cite?
AbstractTooth morphogenesis is regulated by sequential and reciprocal interaction between oral epithelium and neural-crest-derived ectomesenchyme. The interaction is controlled by various signal molecules such as bone morphogenetic protein (BMP), Hedgehog, Wbroblast growth factor (FGF), and Wnt. Zeb family is known as a transcription factor, which is essential for neural development and neural-crest-derived tissues, whereas the role of the Zeb family in tooth development remains unclear. Therefore, this study aimed to investigate the expression proWles of Zeb1 and Zeb2 during craniofacial development focusing on mesenchyme of palate, hair follicle, and tooth germ from E12.5 to E16.5. In addition, we examined the interaction between Zeb family and BMP4 during tooth development. Both Zeb1 and Zeb2 were expressed at mesenchyme of the palate, hair follicle, and tooth germ throughout the stages. In the case of tooth germ at the cap stage, the expression of Zeb1 and Zeb2 was lost in epithelium-separated dental mesenchyme. However, the expression of Zeb1 and Zeb2 in the dental mesenchyme was recovered by Bmp4 signaling via BMP4-soaked bead and tissue recombination. Our results suggest that Zeb1 and Zeb2, which were mediated by BMP4, play an important role in neural-crestderived craniofacial organ morphogenesis, such as tooth development. © Springer-Verlag 2012.
Persistent Identifierhttp://hdl.handle.net/10722/169595
ISSN
2015 Impact Factor: 2.78
2015 SCImago Journal Rankings: 1.287
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShin, JOen_US
dc.contributor.authorKim, EJen_US
dc.contributor.authorCho, KWen_US
dc.contributor.authorNakagawa, Een_US
dc.contributor.authorKwon, HJen_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:53:17Z-
dc.date.available2012-10-25T04:53:17Z-
dc.date.issued2012en_US
dc.identifier.citationHistochemistry And Cell Biology, 2012, v. 137 n. 6, p. 791-800en_US
dc.identifier.issn0948-6143en_US
dc.identifier.urihttp://hdl.handle.net/10722/169595-
dc.description.abstractTooth morphogenesis is regulated by sequential and reciprocal interaction between oral epithelium and neural-crest-derived ectomesenchyme. The interaction is controlled by various signal molecules such as bone morphogenetic protein (BMP), Hedgehog, Wbroblast growth factor (FGF), and Wnt. Zeb family is known as a transcription factor, which is essential for neural development and neural-crest-derived tissues, whereas the role of the Zeb family in tooth development remains unclear. Therefore, this study aimed to investigate the expression proWles of Zeb1 and Zeb2 during craniofacial development focusing on mesenchyme of palate, hair follicle, and tooth germ from E12.5 to E16.5. In addition, we examined the interaction between Zeb family and BMP4 during tooth development. Both Zeb1 and Zeb2 were expressed at mesenchyme of the palate, hair follicle, and tooth germ throughout the stages. In the case of tooth germ at the cap stage, the expression of Zeb1 and Zeb2 was lost in epithelium-separated dental mesenchyme. However, the expression of Zeb1 and Zeb2 in the dental mesenchyme was recovered by Bmp4 signaling via BMP4-soaked bead and tissue recombination. Our results suggest that Zeb1 and Zeb2, which were mediated by BMP4, play an important role in neural-crestderived craniofacial organ morphogenesis, such as tooth development. © Springer-Verlag 2012.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00418/index.htmen_US
dc.relation.ispartofHistochemistry and Cell Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Morphogenetic Protein 4 - Metabolismen_US
dc.subject.meshEmbryo, Mammalianen_US
dc.subject.meshHomeodomain Proteins - Genetics - Metabolismen_US
dc.subject.meshKruppel-Like Transcription Factors - Genetics - Metabolismen_US
dc.subject.meshMesoderm - Embryology - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshOdontogenesis - Geneticsen_US
dc.subject.meshRepressor Proteins - Genetics - Metabolismen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTooth - Embryology - Metabolismen_US
dc.subject.meshTooth Germ - Embryology - Metabolismen_US
dc.titleBMP4 signaling mediates Zeb family in developing mouse toothen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00418-012-0930-7en_US
dc.identifier.pmid22350174-
dc.identifier.scopuseid_2-s2.0-84865122868en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865122868&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume137en_US
dc.identifier.issue6en_US
dc.identifier.spage791en_US
dc.identifier.epage800en_US
dc.identifier.isiWOS:000304165200007-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridShin, JO=37361704500en_US
dc.identifier.scopusauthoridKim, EJ=36064163200en_US
dc.identifier.scopusauthoridCho, KW=7403956665en_US
dc.identifier.scopusauthoridNakagawa, E=52364474400en_US
dc.identifier.scopusauthoridKwon, HJ=18836582500en_US
dc.identifier.scopusauthoridCho, SW=54975942000en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.citeulike10408049-

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