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Article: The novel expression of Oct3/4 and Bmi1 in the root development of mouse molars

TitleThe novel expression of Oct3/4 and Bmi1 in the root development of mouse molars
Authors
KeywordsBmi1
Oct3/4
Root Elongation
Stem Cell
Tooth
Issue Date2012
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell And Tissue Research, 2012, v. 347 n. 2, p. 479-484 How to Cite?
Abstract
The root apex of the tooth elongates until the completion of root development. Although the signaling molecules inducing root elongation have been studied, the characteristic of the cells having the ability to maintain the root elongation remains unclear. This study aimed to investigate the characteristics of the cells involved in the root elongation. Octamer-binding factor 3/4 (Oct3/4) is known as one of the key regulators in maintaining the pluripotency and self-renewal properties of embryonic stem cells. Bmi1, the polycomb-group transcriptional repressor, has emerged as a key regulator in several cellular processes including stem cell self-renewal and cancer cell proliferation. At the beginning of root formation, ameloblasts expressed Oct3/4 in the nucleus, except in the apex of the cervical loop, in which Bmi1and cyclinD were expressed. At PN6, the expression of Oct3/4 in the ameloblasts shifted from the nucleus to the cytoplasm, whereas ameloblastin-negative Hertwig's epithelial root sheath (HERS) cells expressed Bmi1 and cyclinD. By PN10, the cells in the apex of HERS began to express Oct3/4 in their nucleus, whereas Bmi1 and cyclinD began to decrease in their expressions. The odontoblasts consistently expressed Oct3/4 in their cytoplasm. Our results suggest that (1) Oct3/4 creates the border between the ameloblasts from the proliferative region of HERS, (2) Bmi1-positive cells would be one of the candidates resulting in root elongation and (3) the Oct3/4 expression in the cytoplasm of odontoblasts may be related to maintain the odontoblastic characteristics. © Springer-Verlag 2012.
Persistent Identifierhttp://hdl.handle.net/10722/169591
ISSN
2013 Impact Factor: 3.333
ISI Accession Number ID
References

 

Author Affiliations
  1. Wuhan University
  2. Niigata University School of Medicine
  3. Yonsei University
DC FieldValueLanguage
dc.contributor.authorNakagawa, Een_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorShin, JOen_US
dc.contributor.authorKim, EJen_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorOhshima, Hen_US
dc.contributor.authorChen, Zen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:53:14Z-
dc.date.available2012-10-25T04:53:14Z-
dc.date.issued2012en_US
dc.identifier.citationCell And Tissue Research, 2012, v. 347 n. 2, p. 479-484en_US
dc.identifier.issn0302-766Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169591-
dc.description.abstractThe root apex of the tooth elongates until the completion of root development. Although the signaling molecules inducing root elongation have been studied, the characteristic of the cells having the ability to maintain the root elongation remains unclear. This study aimed to investigate the characteristics of the cells involved in the root elongation. Octamer-binding factor 3/4 (Oct3/4) is known as one of the key regulators in maintaining the pluripotency and self-renewal properties of embryonic stem cells. Bmi1, the polycomb-group transcriptional repressor, has emerged as a key regulator in several cellular processes including stem cell self-renewal and cancer cell proliferation. At the beginning of root formation, ameloblasts expressed Oct3/4 in the nucleus, except in the apex of the cervical loop, in which Bmi1and cyclinD were expressed. At PN6, the expression of Oct3/4 in the ameloblasts shifted from the nucleus to the cytoplasm, whereas ameloblastin-negative Hertwig's epithelial root sheath (HERS) cells expressed Bmi1 and cyclinD. By PN10, the cells in the apex of HERS began to express Oct3/4 in their nucleus, whereas Bmi1 and cyclinD began to decrease in their expressions. The odontoblasts consistently expressed Oct3/4 in their cytoplasm. Our results suggest that (1) Oct3/4 creates the border between the ameloblasts from the proliferative region of HERS, (2) Bmi1-positive cells would be one of the candidates resulting in root elongation and (3) the Oct3/4 expression in the cytoplasm of odontoblasts may be related to maintain the odontoblastic characteristics. © Springer-Verlag 2012.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htmen_US
dc.relation.ispartofCell and Tissue Researchen_US
dc.subjectBmi1en_US
dc.subjectOct3/4en_US
dc.subjectRoot Elongationen_US
dc.subjectStem Cellen_US
dc.subjectToothen_US
dc.titleThe novel expression of Oct3/4 and Bmi1 in the root development of mouse molarsen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00441-011-1310-7en_US
dc.identifier.pmid22287043-
dc.identifier.scopuseid_2-s2.0-84862826333en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862826333&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume347en_US
dc.identifier.issue2en_US
dc.identifier.spage479en_US
dc.identifier.epage484en_US
dc.identifier.isiWOS:000302138300016-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridNakagawa, E=52364474400en_US
dc.identifier.scopusauthoridZhang, L=35785341800en_US
dc.identifier.scopusauthoridShin, JO=37361704500en_US
dc.identifier.scopusauthoridKim, EJ=55261523800en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridOhshima, H=7202879991en_US
dc.identifier.scopusauthoridChen, Z=36067468100en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.citeulike10315015-

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