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Article: The novel expression of Oct3/4 and Bmi1 in the root development of mouse molars
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TitleThe novel expression of Oct3/4 and Bmi1 in the root development of mouse molars
 
AuthorsNakagawa, E3
Zhang, L1 3
Shin, JO3
Kim, EJ3
Cho, SW3
Ohshima, H2
Chen, Z1
Jung, HS3
 
KeywordsBmi1
Oct3/4
Root Elongation
Stem Cell
Tooth
 
Issue Date2012
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
 
CitationCell And Tissue Research, 2012, v. 347 n. 2, p. 479-484 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1310-7
 
AbstractThe root apex of the tooth elongates until the completion of root development. Although the signaling molecules inducing root elongation have been studied, the characteristic of the cells having the ability to maintain the root elongation remains unclear. This study aimed to investigate the characteristics of the cells involved in the root elongation. Octamer-binding factor 3/4 (Oct3/4) is known as one of the key regulators in maintaining the pluripotency and self-renewal properties of embryonic stem cells. Bmi1, the polycomb-group transcriptional repressor, has emerged as a key regulator in several cellular processes including stem cell self-renewal and cancer cell proliferation. At the beginning of root formation, ameloblasts expressed Oct3/4 in the nucleus, except in the apex of the cervical loop, in which Bmi1and cyclinD were expressed. At PN6, the expression of Oct3/4 in the ameloblasts shifted from the nucleus to the cytoplasm, whereas ameloblastin-negative Hertwig's epithelial root sheath (HERS) cells expressed Bmi1 and cyclinD. By PN10, the cells in the apex of HERS began to express Oct3/4 in their nucleus, whereas Bmi1 and cyclinD began to decrease in their expressions. The odontoblasts consistently expressed Oct3/4 in their cytoplasm. Our results suggest that (1) Oct3/4 creates the border between the ameloblasts from the proliferative region of HERS, (2) Bmi1-positive cells would be one of the candidates resulting in root elongation and (3) the Oct3/4 expression in the cytoplasm of odontoblasts may be related to maintain the odontoblastic characteristics. © Springer-Verlag 2012.
 
ISSN0302-766X
2012 Impact Factor: 3.677
2012 SCImago Journal Rankings: 1.143
 
DOIhttp://dx.doi.org/10.1007/s00441-011-1310-7
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNakagawa, E
 
dc.contributor.authorZhang, L
 
dc.contributor.authorShin, JO
 
dc.contributor.authorKim, EJ
 
dc.contributor.authorCho, SW
 
dc.contributor.authorOhshima, H
 
dc.contributor.authorChen, Z
 
dc.contributor.authorJung, HS
 
dc.date.accessioned2012-10-25T04:53:14Z
 
dc.date.available2012-10-25T04:53:14Z
 
dc.date.issued2012
 
dc.description.abstractThe root apex of the tooth elongates until the completion of root development. Although the signaling molecules inducing root elongation have been studied, the characteristic of the cells having the ability to maintain the root elongation remains unclear. This study aimed to investigate the characteristics of the cells involved in the root elongation. Octamer-binding factor 3/4 (Oct3/4) is known as one of the key regulators in maintaining the pluripotency and self-renewal properties of embryonic stem cells. Bmi1, the polycomb-group transcriptional repressor, has emerged as a key regulator in several cellular processes including stem cell self-renewal and cancer cell proliferation. At the beginning of root formation, ameloblasts expressed Oct3/4 in the nucleus, except in the apex of the cervical loop, in which Bmi1and cyclinD were expressed. At PN6, the expression of Oct3/4 in the ameloblasts shifted from the nucleus to the cytoplasm, whereas ameloblastin-negative Hertwig's epithelial root sheath (HERS) cells expressed Bmi1 and cyclinD. By PN10, the cells in the apex of HERS began to express Oct3/4 in their nucleus, whereas Bmi1 and cyclinD began to decrease in their expressions. The odontoblasts consistently expressed Oct3/4 in their cytoplasm. Our results suggest that (1) Oct3/4 creates the border between the ameloblasts from the proliferative region of HERS, (2) Bmi1-positive cells would be one of the candidates resulting in root elongation and (3) the Oct3/4 expression in the cytoplasm of odontoblasts may be related to maintain the odontoblastic characteristics. © Springer-Verlag 2012.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCell And Tissue Research, 2012, v. 347 n. 2, p. 479-484 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1310-7
 
dc.identifier.citeulike10315015
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-011-1310-7
 
dc.identifier.epage484
 
dc.identifier.issn0302-766X
2012 Impact Factor: 3.677
2012 SCImago Journal Rankings: 1.143
 
dc.identifier.issue2
 
dc.identifier.pmid22287043
 
dc.identifier.scopuseid_2-s2.0-84862826333
 
dc.identifier.spage479
 
dc.identifier.urihttp://hdl.handle.net/10722/169591
 
dc.identifier.volume347
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofCell and Tissue Research
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBmi1
 
dc.subjectOct3/4
 
dc.subjectRoot Elongation
 
dc.subjectStem Cell
 
dc.subjectTooth
 
dc.titleThe novel expression of Oct3/4 and Bmi1 in the root development of mouse molars
 
dc.typeArticle
 
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<contributor.author>Cho, SW</contributor.author>
<contributor.author>Ohshima, H</contributor.author>
<contributor.author>Chen, Z</contributor.author>
<contributor.author>Jung, HS</contributor.author>
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Author Affiliations
  1. Wuhan University
  2. Niigata University School of Medicine
  3. Yonsei University