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Article: Effect of alendronate on healing of extraction sockets and healing around implants
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TitleEffect of alendronate on healing of extraction sockets and healing around implants
 
AuthorsKim, JH1
Park, YB1
Li, Z1
Shim, JS1
Moon, HS1
Jung, HS1
Chung, MK1
 
Issue Date2011
 
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
 
CitationOral Diseases, 2011, v. 17 n. 7, p. 705-711 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1601-0825.2011.01829.x
 
AbstractObjectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. © 2011 John Wiley & Sons A/S.
 
ISSN1354-523X
2013 Impact Factor: 2.404
 
DOIhttp://dx.doi.org/10.1111/j.1601-0825.2011.01829.x
 
ISI Accession Number IDWOS:000295052100012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKim, JH
 
dc.contributor.authorPark, YB
 
dc.contributor.authorLi, Z
 
dc.contributor.authorShim, JS
 
dc.contributor.authorMoon, HS
 
dc.contributor.authorJung, HS
 
dc.contributor.authorChung, MK
 
dc.date.accessioned2012-10-25T04:53:08Z
 
dc.date.available2012-10-25T04:53:08Z
 
dc.date.issued2011
 
dc.description.abstractObjectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. © 2011 John Wiley & Sons A/S.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationOral Diseases, 2011, v. 17 n. 7, p. 705-711 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1601-0825.2011.01829.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1601-0825.2011.01829.x
 
dc.identifier.epage711
 
dc.identifier.isiWOS:000295052100012
 
dc.identifier.issn1354-523X
2013 Impact Factor: 2.404
 
dc.identifier.issue7
 
dc.identifier.pmid21771209
 
dc.identifier.scopuseid_2-s2.0-80052575518
 
dc.identifier.spage705
 
dc.identifier.urihttp://hdl.handle.net/10722/169583
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
 
dc.publisher.placeUnited States
 
dc.relation.ispartofOral Diseases
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAcid Phosphatase - Analysis
 
dc.subject.meshAlendronate - Pharmacology
 
dc.subject.meshAlveolar Bone Loss - Prevention & Control
 
dc.subject.meshAnimals
 
dc.subject.meshAzo Compounds - Diagnostic Use
 
dc.subject.meshBiological Markers - Analysis
 
dc.subject.meshBone Density Conservation Agents - Pharmacology
 
dc.subject.meshCollagen Type I - Analysis
 
dc.subject.meshColoring Agents - Diagnostic Use
 
dc.subject.meshDental Implantation, Endosseous - Instrumentation
 
dc.subject.meshDental Implants
 
dc.subject.meshDental Materials - Chemistry
 
dc.subject.meshEosine Yellowish-(Ys) - Diagnostic Use
 
dc.subject.meshIsoenzymes - Analysis
 
dc.subject.meshMale
 
dc.subject.meshMaxilla - Drug Effects - Pathology
 
dc.subject.meshMethyl Green - Diagnostic Use
 
dc.subject.meshMolar - Surgery
 
dc.subject.meshOsseointegration - Drug Effects
 
dc.subject.meshOsteoclasts - Pathology
 
dc.subject.meshOsteogenesis - Drug Effects
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.subject.meshTime Factors
 
dc.subject.meshTitanium - Chemistry
 
dc.subject.meshTooth Extraction
 
dc.subject.meshTooth Socket - Drug Effects - Pathology
 
dc.subject.meshWound Healing - Drug Effects
 
dc.titleEffect of alendronate on healing of extraction sockets and healing around implants
 
dc.typeArticle
 
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Author Affiliations
  1. Yonsei University College of Medicine