Article: Effect of alendronate on healing of extraction sockets and healing around implants

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TitleEffect of alendronate on healing of extraction sockets and healing around implants
AuthorsKim, JH1
Park, YB1
Li, Z1
Shim, JS1
Moon, HS1
Jung, HS1
Chung, MK1
Issue Date2011
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
CitationOral Diseases, 2011, v. 17 n. 7, p. 705-711 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1601-0825.2011.01829.x
AbstractObjectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. © 2011 John Wiley & Sons A/S.
ISSN1354-523X
2011 Impact Factor: 2.495
2011 SCImago Journal Rankings: 0.168
DOIhttp://dx.doi.org/10.1111/j.1601-0825.2011.01829.x
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKim, JH
dc.contributor.authorPark, YB
dc.contributor.authorLi, Z
dc.contributor.authorShim, JS
dc.contributor.authorMoon, HS
dc.contributor.authorJung, HS
dc.contributor.authorChung, MK
dc.date.accessioned2012-10-25T04:53:08Z
dc.date.available2012-10-25T04:53:08Z
dc.date.issued2011
dc.description.abstractObjectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. © 2011 John Wiley & Sons A/S.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationOral Diseases, 2011, v. 17 n. 7, p. 705-711 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1601-0825.2011.01829.x
dc.identifier.doihttp://dx.doi.org/10.1111/j.1601-0825.2011.01829.x
dc.identifier.epage711
dc.identifier.issn1354-523X
2011 Impact Factor: 2.495
2011 SCImago Journal Rankings: 0.168
dc.identifier.issue7
dc.identifier.pmid21771209
dc.identifier.scopuseid_2-s2.0-80052575518
dc.identifier.spage705
dc.identifier.urihttp://hdl.handle.net/10722/169583
dc.identifier.volume17
dc.languageeng
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
dc.publisher.placeUnited States
dc.relation.ispartofOral Diseases
dc.relation.referencesReferences in Scopus
dc.subject.meshAcid Phosphatase - Analysis
dc.subject.meshAlendronate - Pharmacology
dc.subject.meshAlveolar Bone Loss - Prevention & Control
dc.subject.meshAnimals
dc.subject.meshAzo Compounds - Diagnostic Use
dc.subject.meshBiological Markers - Analysis
dc.subject.meshBone Density Conservation Agents - Pharmacology
dc.subject.meshCollagen Type I - Analysis
dc.subject.meshColoring Agents - Diagnostic Use
dc.subject.meshDental Implantation, Endosseous - Instrumentation
dc.subject.meshDental Implants
dc.subject.meshDental Materials - Chemistry
dc.subject.meshEosine Yellowish-(Ys) - Diagnostic Use
dc.subject.meshIsoenzymes - Analysis
dc.subject.meshMale
dc.subject.meshMaxilla - Drug Effects - Pathology
dc.subject.meshMethyl Green - Diagnostic Use
dc.subject.meshMolar - Surgery
dc.subject.meshOsseointegration - Drug Effects
dc.subject.meshOsteoclasts - Pathology
dc.subject.meshOsteogenesis - Drug Effects
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshTime Factors
dc.subject.meshTitanium - Chemistry
dc.subject.meshTooth Extraction
dc.subject.meshTooth Socket - Drug Effects - Pathology
dc.subject.meshWound Healing - Drug Effects
dc.titleEffect of alendronate on healing of extraction sockets and healing around implants
dc.typeArticle
Author Affiliations
  1. Yonsei University College of Medicine