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Article: Effect of alendronate on healing of extraction sockets and healing around implants

TitleEffect of alendronate on healing of extraction sockets and healing around implants
Authors
Issue Date2011
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
Citation
Oral Diseases, 2011, v. 17 n. 7, p. 705-711 How to Cite?
AbstractObjectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. © 2011 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/169583
ISSN
2014 Impact Factor: 2.427
2014 SCImago Journal Rankings: 0.746
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKim, JHen_US
dc.contributor.authorPark, YBen_US
dc.contributor.authorLi, Zen_US
dc.contributor.authorShim, JSen_US
dc.contributor.authorMoon, HSen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorChung, MKen_US
dc.date.accessioned2012-10-25T04:53:08Z-
dc.date.available2012-10-25T04:53:08Z-
dc.date.issued2011en_US
dc.identifier.citationOral Diseases, 2011, v. 17 n. 7, p. 705-711en_US
dc.identifier.issn1354-523Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169583-
dc.description.abstractObjectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. © 2011 John Wiley & Sons A/S.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1en_US
dc.relation.ispartofOral Diseasesen_US
dc.subject.meshAcid Phosphatase - Analysisen_US
dc.subject.meshAlendronate - Pharmacologyen_US
dc.subject.meshAlveolar Bone Loss - Prevention & Controlen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAzo Compounds - Diagnostic Useen_US
dc.subject.meshBiological Markers - Analysisen_US
dc.subject.meshBone Density Conservation Agents - Pharmacologyen_US
dc.subject.meshCollagen Type I - Analysisen_US
dc.subject.meshColoring Agents - Diagnostic Useen_US
dc.subject.meshDental Implantation, Endosseous - Instrumentationen_US
dc.subject.meshDental Implantsen_US
dc.subject.meshDental Materials - Chemistryen_US
dc.subject.meshEosine Yellowish-(Ys) - Diagnostic Useen_US
dc.subject.meshIsoenzymes - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMaxilla - Drug Effects - Pathologyen_US
dc.subject.meshMethyl Green - Diagnostic Useen_US
dc.subject.meshMolar - Surgeryen_US
dc.subject.meshOsseointegration - Drug Effectsen_US
dc.subject.meshOsteoclasts - Pathologyen_US
dc.subject.meshOsteogenesis - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTitanium - Chemistryen_US
dc.subject.meshTooth Extractionen_US
dc.subject.meshTooth Socket - Drug Effects - Pathologyen_US
dc.subject.meshWound Healing - Drug Effectsen_US
dc.titleEffect of alendronate on healing of extraction sockets and healing around implantsen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1601-0825.2011.01829.xen_US
dc.identifier.pmid21771209-
dc.identifier.scopuseid_2-s2.0-80052575518en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052575518&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue7en_US
dc.identifier.spage705en_US
dc.identifier.epage711en_US
dc.identifier.isiWOS:000295052100012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKim, JH=51763838500en_US
dc.identifier.scopusauthoridPark, YB=7405369878en_US
dc.identifier.scopusauthoridLi, Z=51763934300en_US
dc.identifier.scopusauthoridShim, JS=35325524200en_US
dc.identifier.scopusauthoridMoon, HS=36912762000en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridChung, MK=36514262900en_US

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