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Article: Function analysis of mesenchymal Bcor in tooth development by using RNA interference
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TitleFunction analysis of mesenchymal Bcor in tooth development by using RNA interference
 
AuthorsCai, J1 2
Kwak, S1
Lee, JM1
Kim, EJ1
Lee, MJ1
Park, GH1
Cho, SW1
Jung, HS1
 
Issue Date2010
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
 
CitationCell And Tissue Research, 2010, v. 341 n. 2, p. 251-258 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-010-0996-2
 
AbstractTeeth, an excellent model for studying organogenesis, develop from a series of epithelial-mesenchymal interactions that are mediated by a complex molecular network. Bcor (BCL-6 interacting corepressor) has recently been discovered, but little is known about its function in tooth development. Mutations in BCOR affect humans with oculofaciocardiodental syndrome, which is an X-linked dominant disorder with presumed male lethality and which comprises microphthalmia, congenital cataracts, radiculomegaly, and cardiac and digital abnormalities. In this study, the Bcor expression pattern has been intensively investigated during mouse molar development. Bcor is expressed in both dental epithelium and the mesenchyme at E11.5. To understand the function of Bcor, knockdown of Bcor has been examined by using lentivirus-mediated RNA interference. Silencing of Bcor expression in dental mesenchymal cells at E14.5 causes dentinogenesis defects and retardation of tooth root development. Thus, our results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. The function of Bcor expressed in the epithelium remains to be elucidated. © 2010 Springer-Verlag.
 
ISSN0302-766X
2013 Impact Factor: 3.333
 
DOIhttp://dx.doi.org/10.1007/s00441-010-0996-2
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCai, J
 
dc.contributor.authorKwak, S
 
dc.contributor.authorLee, JM
 
dc.contributor.authorKim, EJ
 
dc.contributor.authorLee, MJ
 
dc.contributor.authorPark, GH
 
dc.contributor.authorCho, SW
 
dc.contributor.authorJung, HS
 
dc.date.accessioned2012-10-25T04:52:59Z
 
dc.date.available2012-10-25T04:52:59Z
 
dc.date.issued2010
 
dc.description.abstractTeeth, an excellent model for studying organogenesis, develop from a series of epithelial-mesenchymal interactions that are mediated by a complex molecular network. Bcor (BCL-6 interacting corepressor) has recently been discovered, but little is known about its function in tooth development. Mutations in BCOR affect humans with oculofaciocardiodental syndrome, which is an X-linked dominant disorder with presumed male lethality and which comprises microphthalmia, congenital cataracts, radiculomegaly, and cardiac and digital abnormalities. In this study, the Bcor expression pattern has been intensively investigated during mouse molar development. Bcor is expressed in both dental epithelium and the mesenchyme at E11.5. To understand the function of Bcor, knockdown of Bcor has been examined by using lentivirus-mediated RNA interference. Silencing of Bcor expression in dental mesenchymal cells at E14.5 causes dentinogenesis defects and retardation of tooth root development. Thus, our results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. The function of Bcor expressed in the epithelium remains to be elucidated. © 2010 Springer-Verlag.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCell And Tissue Research, 2010, v. 341 n. 2, p. 251-258 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-010-0996-2
 
dc.identifier.citeulike7417126
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-010-0996-2
 
dc.identifier.epage258
 
dc.identifier.issn0302-766X
2013 Impact Factor: 3.333
 
dc.identifier.issue2
 
dc.identifier.pmid20563598
 
dc.identifier.scopuseid_2-s2.0-77956181588
 
dc.identifier.spage251
 
dc.identifier.urihttp://hdl.handle.net/10722/169571
 
dc.identifier.volume341
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofCell and Tissue Research
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshGene Expression Regulation, Developmental
 
dc.subject.meshHumans
 
dc.subject.meshLentivirus - Genetics
 
dc.subject.meshMale
 
dc.subject.meshMesoderm - Embryology - Metabolism
 
dc.subject.meshMice
 
dc.subject.meshMice, Inbred Balb C
 
dc.subject.meshMice, Inbred Icr
 
dc.subject.meshOdontogenesis - Genetics
 
dc.subject.meshRna Interference
 
dc.subject.meshRepressor Proteins - Antagonists & Inhibitors - Genetics - Metabolism
 
dc.subject.meshTooth - Embryology - Metabolism
 
dc.titleFunction analysis of mesenchymal Bcor in tooth development by using RNA interference
 
dc.typeArticle
 
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Author Affiliations
  1. Yonsei University
  2. Chinese Academy of Sciences