Article: Function analysis of mesenchymal Bcor in tooth development by using RNA interference

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TitleFunction analysis of mesenchymal Bcor in tooth development by using RNA interference
AuthorsCai, J1 2
Kwak, S1
Lee, JM1
Kim, EJ1
Lee, MJ1
Park, GH1
Cho, SW1
Jung, HS1
Issue Date2010
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
CitationCell And Tissue Research, 2010, v. 341 n. 2, p. 251-258 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-010-0996-2
AbstractTeeth, an excellent model for studying organogenesis, develop from a series of epithelial-mesenchymal interactions that are mediated by a complex molecular network. Bcor (BCL-6 interacting corepressor) has recently been discovered, but little is known about its function in tooth development. Mutations in BCOR affect humans with oculofaciocardiodental syndrome, which is an X-linked dominant disorder with presumed male lethality and which comprises microphthalmia, congenital cataracts, radiculomegaly, and cardiac and digital abnormalities. In this study, the Bcor expression pattern has been intensively investigated during mouse molar development. Bcor is expressed in both dental epithelium and the mesenchyme at E11.5. To understand the function of Bcor, knockdown of Bcor has been examined by using lentivirus-mediated RNA interference. Silencing of Bcor expression in dental mesenchymal cells at E14.5 causes dentinogenesis defects and retardation of tooth root development. Thus, our results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. The function of Bcor expressed in the epithelium remains to be elucidated. © 2010 Springer-Verlag.
ISSN0302-766X
2011 Impact Factor: 3.114
2011 SCImago Journal Rankings: 0.333
DOIhttp://dx.doi.org/10.1007/s00441-010-0996-2
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCai, J
dc.contributor.authorKwak, S
dc.contributor.authorLee, JM
dc.contributor.authorKim, EJ
dc.contributor.authorLee, MJ
dc.contributor.authorPark, GH
dc.contributor.authorCho, SW
dc.contributor.authorJung, HS
dc.date.accessioned2012-10-25T04:52:59Z
dc.date.available2012-10-25T04:52:59Z
dc.date.issued2010
dc.description.abstractTeeth, an excellent model for studying organogenesis, develop from a series of epithelial-mesenchymal interactions that are mediated by a complex molecular network. Bcor (BCL-6 interacting corepressor) has recently been discovered, but little is known about its function in tooth development. Mutations in BCOR affect humans with oculofaciocardiodental syndrome, which is an X-linked dominant disorder with presumed male lethality and which comprises microphthalmia, congenital cataracts, radiculomegaly, and cardiac and digital abnormalities. In this study, the Bcor expression pattern has been intensively investigated during mouse molar development. Bcor is expressed in both dental epithelium and the mesenchyme at E11.5. To understand the function of Bcor, knockdown of Bcor has been examined by using lentivirus-mediated RNA interference. Silencing of Bcor expression in dental mesenchymal cells at E14.5 causes dentinogenesis defects and retardation of tooth root development. Thus, our results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. The function of Bcor expressed in the epithelium remains to be elucidated. © 2010 Springer-Verlag.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCell And Tissue Research, 2010, v. 341 n. 2, p. 251-258 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-010-0996-2
dc.identifier.citeulike7417126
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-010-0996-2
dc.identifier.epage258
dc.identifier.issn0302-766X
2011 Impact Factor: 3.114
2011 SCImago Journal Rankings: 0.333
dc.identifier.issue2
dc.identifier.pmid20563598
dc.identifier.scopuseid_2-s2.0-77956181588
dc.identifier.spage251
dc.identifier.urihttp://hdl.handle.net/10722/169571
dc.identifier.volume341
dc.languageeng
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
dc.publisher.placeGermany
dc.relation.ispartofCell and Tissue Research
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshGene Expression Regulation, Developmental
dc.subject.meshHumans
dc.subject.meshLentivirus - Genetics
dc.subject.meshMale
dc.subject.meshMesoderm - Embryology - Metabolism
dc.subject.meshMice
dc.subject.meshMice, Inbred Balb C
dc.subject.meshMice, Inbred Icr
dc.subject.meshOdontogenesis - Genetics
dc.subject.meshRna Interference
dc.subject.meshRepressor Proteins - Antagonists & Inhibitors - Genetics - Metabolism
dc.subject.meshTooth - Embryology - Metabolism
dc.titleFunction analysis of mesenchymal Bcor in tooth development by using RNA interference
dc.typeArticle
Author Affiliations
  1. Yonsei University
  2. Chinese Academy of Sciences