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Article: Function analysis of mesenchymal Bcor in tooth development by using RNA interference

TitleFunction analysis of mesenchymal Bcor in tooth development by using RNA interference
Authors
Issue Date2010
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell And Tissue Research, 2010, v. 341 n. 2, p. 251-258 How to Cite?
AbstractTeeth, an excellent model for studying organogenesis, develop from a series of epithelial-mesenchymal interactions that are mediated by a complex molecular network. Bcor (BCL-6 interacting corepressor) has recently been discovered, but little is known about its function in tooth development. Mutations in BCOR affect humans with oculofaciocardiodental syndrome, which is an X-linked dominant disorder with presumed male lethality and which comprises microphthalmia, congenital cataracts, radiculomegaly, and cardiac and digital abnormalities. In this study, the Bcor expression pattern has been intensively investigated during mouse molar development. Bcor is expressed in both dental epithelium and the mesenchyme at E11.5. To understand the function of Bcor, knockdown of Bcor has been examined by using lentivirus-mediated RNA interference. Silencing of Bcor expression in dental mesenchymal cells at E14.5 causes dentinogenesis defects and retardation of tooth root development. Thus, our results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. The function of Bcor expressed in the epithelium remains to be elucidated. © 2010 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/169571
ISSN
2014 Impact Factor: 3.565
2014 SCImago Journal Rankings: 1.293
References

 

DC FieldValueLanguage
dc.contributor.authorCai, Jen_US
dc.contributor.authorKwak, Sen_US
dc.contributor.authorLee, JMen_US
dc.contributor.authorKim, EJen_US
dc.contributor.authorLee, MJen_US
dc.contributor.authorPark, GHen_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:52:59Z-
dc.date.available2012-10-25T04:52:59Z-
dc.date.issued2010en_US
dc.identifier.citationCell And Tissue Research, 2010, v. 341 n. 2, p. 251-258en_US
dc.identifier.issn0302-766Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169571-
dc.description.abstractTeeth, an excellent model for studying organogenesis, develop from a series of epithelial-mesenchymal interactions that are mediated by a complex molecular network. Bcor (BCL-6 interacting corepressor) has recently been discovered, but little is known about its function in tooth development. Mutations in BCOR affect humans with oculofaciocardiodental syndrome, which is an X-linked dominant disorder with presumed male lethality and which comprises microphthalmia, congenital cataracts, radiculomegaly, and cardiac and digital abnormalities. In this study, the Bcor expression pattern has been intensively investigated during mouse molar development. Bcor is expressed in both dental epithelium and the mesenchyme at E11.5. To understand the function of Bcor, knockdown of Bcor has been examined by using lentivirus-mediated RNA interference. Silencing of Bcor expression in dental mesenchymal cells at E14.5 causes dentinogenesis defects and retardation of tooth root development. Thus, our results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. The function of Bcor expressed in the epithelium remains to be elucidated. © 2010 Springer-Verlag.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htmen_US
dc.relation.ispartofCell and Tissue Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshHumansen_US
dc.subject.meshLentivirus - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMesoderm - Embryology - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshOdontogenesis - Geneticsen_US
dc.subject.meshRna Interferenceen_US
dc.subject.meshRepressor Proteins - Antagonists & Inhibitors - Genetics - Metabolismen_US
dc.subject.meshTooth - Embryology - Metabolismen_US
dc.titleFunction analysis of mesenchymal Bcor in tooth development by using RNA interferenceen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00441-010-0996-2en_US
dc.identifier.pmid20563598en_US
dc.identifier.scopuseid_2-s2.0-77956181588en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956181588&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume341en_US
dc.identifier.issue2en_US
dc.identifier.spage251en_US
dc.identifier.epage258en_US
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridCai, J=9246458800en_US
dc.identifier.scopusauthoridKwak, S=7202607781en_US
dc.identifier.scopusauthoridLee, JM=25622544900en_US
dc.identifier.scopusauthoridKim, EJ=36064163200en_US
dc.identifier.scopusauthoridLee, MJ=35264472100en_US
dc.identifier.scopusauthoridPark, GH=36497189000en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.citeulike7417126-

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