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Article: Down-regulated genes in mouse dental papillae and pulp

TitleDown-regulated genes in mouse dental papillae and pulp
Authors
Issue Date2010
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2010, v. 89 n. 7, p. 679-683 How to Cite?
AbstractImportant factors involved in odontogenesis in mouse dental papillae disappear between the pre-and post-natal stages of development. Therefore, we hypothesized that certain genes involved in odontogenesis in dental papillae were subject to pre-/post-natal down-regulation. Our goal was to identify, by microarray analysis, which genes were down-regulated. Dental papillae were isolated from embryonic 16-day-, 18-day- (E16, E18), and post-natal 3-day-old (P3) murine first mandibular molar germs and analyzed by microarray. The number of down-regulated genes was 2269 between E16 and E18, and 3130 between E18 and P3. Drastic down-regulation (fold change > 10.0) of Adamts4, Aldha1a2, and Lef1 was observed at both E16 and E18, and quantitative RT-PCR revealed a post-natal reduction in their expression (Adamts4, 1/3; Aldh1a2, 1/13; and Lef1, 1/37). These results suggest that down-regulation of these three genes is an important factor in normal odontogenesis in dental papillae.
Persistent Identifierhttp://hdl.handle.net/10722/169569
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSasaki, Hen_US
dc.contributor.authorMuramatsu, Ten_US
dc.contributor.authorKwon, HJen_US
dc.contributor.authorYamamoto, Hen_US
dc.contributor.authorHashimoto, Sen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorShimono, Men_US
dc.date.accessioned2012-10-25T04:52:58Z-
dc.date.available2012-10-25T04:52:58Z-
dc.date.issued2010en_US
dc.identifier.citationJournal Of Dental Research, 2010, v. 89 n. 7, p. 679-683en_US
dc.identifier.issn0022-0345en_US
dc.identifier.urihttp://hdl.handle.net/10722/169569-
dc.description.abstractImportant factors involved in odontogenesis in mouse dental papillae disappear between the pre-and post-natal stages of development. Therefore, we hypothesized that certain genes involved in odontogenesis in dental papillae were subject to pre-/post-natal down-regulation. Our goal was to identify, by microarray analysis, which genes were down-regulated. Dental papillae were isolated from embryonic 16-day-, 18-day- (E16, E18), and post-natal 3-day-old (P3) murine first mandibular molar germs and analyzed by microarray. The number of down-regulated genes was 2269 between E16 and E18, and 3130 between E18 and P3. Drastic down-regulation (fold change > 10.0) of Adamts4, Aldha1a2, and Lef1 was observed at both E16 and E18, and quantitative RT-PCR revealed a post-natal reduction in their expression (Adamts4, 1/3; Aldh1a2, 1/13; and Lef1, 1/37). These results suggest that down-regulation of these three genes is an important factor in normal odontogenesis in dental papillae.en_US
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_US
dc.relation.ispartofJournal of Dental Researchen_US
dc.subject.meshAdam Proteins - Analysis - Geneticsen_US
dc.subject.meshAldehyde Dehydrogenase - Analysis - Geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Death - Geneticsen_US
dc.subject.meshDental Papilla - Cytology - Embryologyen_US
dc.subject.meshDental Pulp - Cytology - Embryologyen_US
dc.subject.meshDown-Regulation - Geneticsen_US
dc.subject.meshEpithelial Cells - Cytologyen_US
dc.subject.meshGene Expression Regulation, Developmental - Geneticsen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshLymphoid Enhancer-Binding Factor 1 - Analysis - Geneticsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshOdontoblasts - Cytologyen_US
dc.subject.meshOdontogenesis - Geneticsen_US
dc.subject.meshOligonucleotide Array Sequence Analysisen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshProcollagen N-Endopeptidase - Analysis - Geneticsen_US
dc.subject.meshTooth Calcification - Geneticsen_US
dc.subject.meshTooth Germ - Cytology - Embryologyen_US
dc.titleDown-regulated genes in mouse dental papillae and pulpen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/0022034510366844en_US
dc.identifier.pmid20448247-
dc.identifier.scopuseid_2-s2.0-77953786455en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953786455&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume89en_US
dc.identifier.issue7en_US
dc.identifier.spage679en_US
dc.identifier.epage683en_US
dc.identifier.isiWOS:000278829300004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSasaki, H=14038203400en_US
dc.identifier.scopusauthoridMuramatsu, T=7402581093en_US
dc.identifier.scopusauthoridKwon, HJ=18836582500en_US
dc.identifier.scopusauthoridYamamoto, H=7501429326en_US
dc.identifier.scopusauthoridHashimoto, S=35556628400en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridShimono, M=19536788600en_US

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