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Article: The role of BMP4 in HERS during tooth root development

TitleThe role of BMP4 in HERS during tooth root development
Authors
KeywordsBead Implantation
Bone Morphogenetic Protein 4
Hertwig's Epithelial Root Sheath
Noggin
Root Formation
Issue Date2008
Citation
Journal Of Oral Biosciences, 2008, v. 50 n. 3, p. 160-166 How to Cite?
Abstract
Tooth development is regulated by reciprocal interactions between epithelial and mesenchymal cells. Several morphological studies suggest that growth factors secreted from these cells regulate tooth development. These growth factors induce undifferentiated cells in the tooth germ to differentiate into tooth-forming cells. Many growth factors are reportedly expressed in the developing tooth, but the key molecule underlying tooth root development is still unknown. There is a considerable amount of data on the expression and function of bone morphogenetic proteins (BMPs) during tooth development, but the relationship between BMPs and tooth root development has not been analyzed extensively. This prompted us to examine the expression patterns of BMP4 and BMP receptors (BMPRs) at the apical region of the tooth germ during mouse tooth root development. We found that BMP4 was strictly expressed in the apical mesenchyme, and that BMPRs were localized in Hertwig's epithelial root sheath (HERS). We also investigated the possible roles of BMP4 in HERS during the early stage of tooth root development. Our organ-culture results indicated that BMP4 regulates HERS formation via harmonious interactions with its own antagonist, noggin, by preventing elongation and maintaining cell proliferation. BMP4 may therefore be useful in various tissue-engineering applications as a regulator of tooth root formation.
Persistent Identifierhttp://hdl.handle.net/10722/169551
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorJung, HSen_US
dc.contributor.authorHosoya, Aen_US
dc.contributor.authorKim, JYen_US
dc.contributor.authorCho, SWen_US
dc.date.accessioned2012-10-25T04:52:47Z-
dc.date.available2012-10-25T04:52:47Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of Oral Biosciences, 2008, v. 50 n. 3, p. 160-166en_US
dc.identifier.issn1349-0079en_US
dc.identifier.urihttp://hdl.handle.net/10722/169551-
dc.description.abstractTooth development is regulated by reciprocal interactions between epithelial and mesenchymal cells. Several morphological studies suggest that growth factors secreted from these cells regulate tooth development. These growth factors induce undifferentiated cells in the tooth germ to differentiate into tooth-forming cells. Many growth factors are reportedly expressed in the developing tooth, but the key molecule underlying tooth root development is still unknown. There is a considerable amount of data on the expression and function of bone morphogenetic proteins (BMPs) during tooth development, but the relationship between BMPs and tooth root development has not been analyzed extensively. This prompted us to examine the expression patterns of BMP4 and BMP receptors (BMPRs) at the apical region of the tooth germ during mouse tooth root development. We found that BMP4 was strictly expressed in the apical mesenchyme, and that BMPRs were localized in Hertwig's epithelial root sheath (HERS). We also investigated the possible roles of BMP4 in HERS during the early stage of tooth root development. Our organ-culture results indicated that BMP4 regulates HERS formation via harmonious interactions with its own antagonist, noggin, by preventing elongation and maintaining cell proliferation. BMP4 may therefore be useful in various tissue-engineering applications as a regulator of tooth root formation.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Oral Biosciencesen_US
dc.subjectBead Implantationen_US
dc.subjectBone Morphogenetic Protein 4en_US
dc.subjectHertwig's Epithelial Root Sheathen_US
dc.subjectNogginen_US
dc.subjectRoot Formationen_US
dc.titleThe role of BMP4 in HERS during tooth root developmenten_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2330/joralbiosci.50.160en_US
dc.identifier.scopuseid_2-s2.0-55149109659en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55149109659&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume50en_US
dc.identifier.issue3en_US
dc.identifier.spage160en_US
dc.identifier.epage166en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridHosoya, A=8651007100en_US
dc.identifier.scopusauthoridKim, JY=7601381285en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US

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