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Article: The role of BMP4 in HERS during tooth root development
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TitleThe role of BMP4 in HERS during tooth root development
 
AuthorsJung, HS2
Hosoya, A2 1
Kim, JY2
Cho, SW2
 
KeywordsBead Implantation
Bone Morphogenetic Protein 4
Hertwig's Epithelial Root Sheath
Noggin
Root Formation
 
Issue Date2008
 
CitationJournal Of Oral Biosciences, 2008, v. 50 n. 3, p. 160-166 [How to Cite?]
DOI: http://dx.doi.org/10.2330/joralbiosci.50.160
 
AbstractTooth development is regulated by reciprocal interactions between epithelial and mesenchymal cells. Several morphological studies suggest that growth factors secreted from these cells regulate tooth development. These growth factors induce undifferentiated cells in the tooth germ to differentiate into tooth-forming cells. Many growth factors are reportedly expressed in the developing tooth, but the key molecule underlying tooth root development is still unknown. There is a considerable amount of data on the expression and function of bone morphogenetic proteins (BMPs) during tooth development, but the relationship between BMPs and tooth root development has not been analyzed extensively. This prompted us to examine the expression patterns of BMP4 and BMP receptors (BMPRs) at the apical region of the tooth germ during mouse tooth root development. We found that BMP4 was strictly expressed in the apical mesenchyme, and that BMPRs were localized in Hertwig's epithelial root sheath (HERS). We also investigated the possible roles of BMP4 in HERS during the early stage of tooth root development. Our organ-culture results indicated that BMP4 regulates HERS formation via harmonious interactions with its own antagonist, noggin, by preventing elongation and maintaining cell proliferation. BMP4 may therefore be useful in various tissue-engineering applications as a regulator of tooth root formation.
 
ISSN1349-0079
 
DOIhttp://dx.doi.org/10.2330/joralbiosci.50.160
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorJung, HS
 
dc.contributor.authorHosoya, A
 
dc.contributor.authorKim, JY
 
dc.contributor.authorCho, SW
 
dc.date.accessioned2012-10-25T04:52:47Z
 
dc.date.available2012-10-25T04:52:47Z
 
dc.date.issued2008
 
dc.description.abstractTooth development is regulated by reciprocal interactions between epithelial and mesenchymal cells. Several morphological studies suggest that growth factors secreted from these cells regulate tooth development. These growth factors induce undifferentiated cells in the tooth germ to differentiate into tooth-forming cells. Many growth factors are reportedly expressed in the developing tooth, but the key molecule underlying tooth root development is still unknown. There is a considerable amount of data on the expression and function of bone morphogenetic proteins (BMPs) during tooth development, but the relationship between BMPs and tooth root development has not been analyzed extensively. This prompted us to examine the expression patterns of BMP4 and BMP receptors (BMPRs) at the apical region of the tooth germ during mouse tooth root development. We found that BMP4 was strictly expressed in the apical mesenchyme, and that BMPRs were localized in Hertwig's epithelial root sheath (HERS). We also investigated the possible roles of BMP4 in HERS during the early stage of tooth root development. Our organ-culture results indicated that BMP4 regulates HERS formation via harmonious interactions with its own antagonist, noggin, by preventing elongation and maintaining cell proliferation. BMP4 may therefore be useful in various tissue-engineering applications as a regulator of tooth root formation.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Oral Biosciences, 2008, v. 50 n. 3, p. 160-166 [How to Cite?]
DOI: http://dx.doi.org/10.2330/joralbiosci.50.160
 
dc.identifier.doihttp://dx.doi.org/10.2330/joralbiosci.50.160
 
dc.identifier.epage166
 
dc.identifier.issn1349-0079
 
dc.identifier.issue3
 
dc.identifier.scopuseid_2-s2.0-55149109659
 
dc.identifier.spage160
 
dc.identifier.urihttp://hdl.handle.net/10722/169551
 
dc.identifier.volume50
 
dc.languageeng
 
dc.relation.ispartofJournal of Oral Biosciences
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBead Implantation
 
dc.subjectBone Morphogenetic Protein 4
 
dc.subjectHertwig's Epithelial Root Sheath
 
dc.subjectNoggin
 
dc.subjectRoot Formation
 
dc.titleThe role of BMP4 in HERS during tooth root development
 
dc.typeArticle
 
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<contributor.author>Cho, SW</contributor.author>
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Author Affiliations
  1. Matsumoto Dental University
  2. Yonsei University College of Medicine