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Article: Sonic hedgehog signaling pathway in vertebrate epithelial appendage morphogenesis: Perspectives in development and evolution

TitleSonic hedgehog signaling pathway in vertebrate epithelial appendage morphogenesis: Perspectives in development and evolution
Authors
Issue Date2000
PublisherBirkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htm
Citation
Cellular And Molecular Life Sciences, 2000, v. 57 n. 12, p. 1672-1681 How to Cite?
AbstractVertebrate epithelial appendages are elaborate topological transformations of flat epithelia into complex organs that either protrude out of external (integument) and internal (oral cavity, gut) epithelia, or invaginate into the surrounding mesenchyme. Although they have specific structures and diverse functions, most epithelial appendages share similar developmental stages, including induction, morphogenesis, differentiation and cycling. The roles of the SHH pathway are analyzed in exemplary organs including feather, hair, tooth, tongue papilla, lung and foregut. SHH is not essential for induction and differentiation, but is involved heavily in morphogenetic processes including cell proliferation (size regulation), branching morphogenesis, mesenchymal condensation, fate determination (segmentation), polarizing activities and so on. Through differential activation of these processes by SHH in a spatiotemporal-specific fashion, organs of different shape and size are laid down. During evolution, new links of developmental pathways may occur and novel forms of epithelial appendages may emerge, upon which evolutionary selections can act. Sites of major variations have progressed from the body plan to the limb plan to the epithelial appendage plan. With its powerful morphogenetic activities, the SHH pathway would likely continue to play a major role in the evolution of novel epithelial appendages.
Persistent Identifierhttp://hdl.handle.net/10722/169536
ISSN
2015 Impact Factor: 5.694
2015 SCImago Journal Rankings: 3.388
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChuong, CMen_US
dc.contributor.authorPatel, Nen_US
dc.contributor.authorLin, Jen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorWidelitz, RBen_US
dc.date.accessioned2012-10-25T04:52:38Z-
dc.date.available2012-10-25T04:52:38Z-
dc.date.issued2000en_US
dc.identifier.citationCellular And Molecular Life Sciences, 2000, v. 57 n. 12, p. 1672-1681en_US
dc.identifier.issn1420-682Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169536-
dc.description.abstractVertebrate epithelial appendages are elaborate topological transformations of flat epithelia into complex organs that either protrude out of external (integument) and internal (oral cavity, gut) epithelia, or invaginate into the surrounding mesenchyme. Although they have specific structures and diverse functions, most epithelial appendages share similar developmental stages, including induction, morphogenesis, differentiation and cycling. The roles of the SHH pathway are analyzed in exemplary organs including feather, hair, tooth, tongue papilla, lung and foregut. SHH is not essential for induction and differentiation, but is involved heavily in morphogenetic processes including cell proliferation (size regulation), branching morphogenesis, mesenchymal condensation, fate determination (segmentation), polarizing activities and so on. Through differential activation of these processes by SHH in a spatiotemporal-specific fashion, organs of different shape and size are laid down. During evolution, new links of developmental pathways may occur and novel forms of epithelial appendages may emerge, upon which evolutionary selections can act. Sites of major variations have progressed from the body plan to the limb plan to the epithelial appendage plan. With its powerful morphogenetic activities, the SHH pathway would likely continue to play a major role in the evolution of novel epithelial appendages.en_US
dc.languageengen_US
dc.publisherBirkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htmen_US
dc.relation.ispartofCellular and Molecular Life Sciencesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Evolutionen_US
dc.subject.meshDigestive System - Growth & Developmenten_US
dc.subject.meshEpithelium - Growth & Developmenten_US
dc.subject.meshFeathers - Growth & Developmenten_US
dc.subject.meshHair - Growth & Developmenten_US
dc.subject.meshHedgehog Proteinsen_US
dc.subject.meshLung - Growth & Developmenten_US
dc.subject.meshProteins - Physiologyen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshSkin - Growth & Developmenten_US
dc.subject.meshTongue - Growth & Developmenten_US
dc.subject.meshTooth - Growth & Developmenten_US
dc.subject.meshTrans-Activatorsen_US
dc.subject.meshVertebratesen_US
dc.titleSonic hedgehog signaling pathway in vertebrate epithelial appendage morphogenesis: Perspectives in development and evolutionen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/PL00000650-
dc.identifier.pmid11130174-
dc.identifier.scopuseid_2-s2.0-0033695047en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033695047&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume57en_US
dc.identifier.issue12en_US
dc.identifier.spage1672en_US
dc.identifier.epage1681en_US
dc.identifier.isiWOS:000165691100002-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridChuong, CM=7103159962en_US
dc.identifier.scopusauthoridPatel, N=35601853200en_US
dc.identifier.scopusauthoridLin, J=8148328500en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridWidelitz, RB=6701556360en_US

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