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Article: The role of long range, local and direct signalling molecules during chick feather bud development involving the BMPs, Follistatin and the Eph receptor tyrosine kinase Eph-A4

TitleThe role of long range, local and direct signalling molecules during chick feather bud development involving the BMPs, Follistatin and the Eph receptor tyrosine kinase Eph-A4
Authors
Issue Date1999
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/modo
Citation
Mechanisms Of Development, 1999, v. 86 n. 1-2, p. 51-62 How to Cite?
AbstractThe development of the feather buds during avian embryogenesis is a classic example of a spacing pattern. The regular arrangement of feather buds is achieved by a process of lateral inhibition whereby one developing feather bud prevents the formation of similar buds in the immediate vicinity. Lateral inhibition during feather formation implicates a role of long range signalling during this process. Recent work has shown that BMPs are able to enforce lateral inhibition during feather bud formation. However these results do not explain how the feather bud escapes the inhibition itself. We show that this could be achieved by the expression of the BMP antagonist, Follistatin. Furthermore we show that local application of Follistatin leads to the development of ectopic feather buds. We suggest that Follistatin locally antagonises the action of the BMPs and so permits the cellular changes associated with feather placode formation. We also provide evidence for the role of short range signalling during feather formation. We have correlated changes in cellular morphology in feather placodes with the expression of the gene Eph-A4 which encodes a receptor tyrosine kinase that requires direct cell-cell contact for activation. We show that the expression of this gene precedes cellular reorganisation required for feather bud formation. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/169530
ISSN
2015 Impact Factor: 2.041
2015 SCImago Journal Rankings: 1.368
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPatel, Ken_US
dc.contributor.authorMakarenkova, Hen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:52:35Z-
dc.date.available2012-10-25T04:52:35Z-
dc.date.issued1999en_US
dc.identifier.citationMechanisms Of Development, 1999, v. 86 n. 1-2, p. 51-62en_US
dc.identifier.issn0925-4773en_US
dc.identifier.urihttp://hdl.handle.net/10722/169530-
dc.description.abstractThe development of the feather buds during avian embryogenesis is a classic example of a spacing pattern. The regular arrangement of feather buds is achieved by a process of lateral inhibition whereby one developing feather bud prevents the formation of similar buds in the immediate vicinity. Lateral inhibition during feather formation implicates a role of long range signalling during this process. Recent work has shown that BMPs are able to enforce lateral inhibition during feather bud formation. However these results do not explain how the feather bud escapes the inhibition itself. We show that this could be achieved by the expression of the BMP antagonist, Follistatin. Furthermore we show that local application of Follistatin leads to the development of ectopic feather buds. We suggest that Follistatin locally antagonises the action of the BMPs and so permits the cellular changes associated with feather placode formation. We also provide evidence for the role of short range signalling during feather formation. We have correlated changes in cellular morphology in feather placodes with the expression of the gene Eph-A4 which encodes a receptor tyrosine kinase that requires direct cell-cell contact for activation. We show that the expression of this gene precedes cellular reorganisation required for feather bud formation. Copyright (C) 1999 Elsevier Science Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/modoen_US
dc.relation.ispartofMechanisms of Developmenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Morphogenetic Protein 7en_US
dc.subject.meshBone Morphogenetic Proteins - Genetics - Metabolismen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshFeathers - Drug Effects - Embryology - Metabolismen_US
dc.subject.meshFetal Proteins - Genetics - Metabolismen_US
dc.subject.meshFibroblast Growth Factor 4en_US
dc.subject.meshFibroblast Growth Factors - Metabolismen_US
dc.subject.meshFollistatinen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshGlycoproteins - Genetics - Metabolism - Pharmacologyen_US
dc.subject.meshProto-Oncogene Proteins - Metabolismen_US
dc.subject.meshReceptor Protein-Tyrosine Kinases - Genetics - Metabolismen_US
dc.subject.meshReceptor, Epha4en_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshSkin - Cytology - Metabolismen_US
dc.subject.meshTransforming Growth Factor Betaen_US
dc.titleThe role of long range, local and direct signalling molecules during chick feather bud development involving the BMPs, Follistatin and the Eph receptor tyrosine kinase Eph-A4en_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0925-4773(99)00107-0en_US
dc.identifier.pmid10446265en_US
dc.identifier.scopuseid_2-s2.0-0032780157en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032780157&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume86en_US
dc.identifier.issue1-2en_US
dc.identifier.spage51en_US
dc.identifier.epage62en_US
dc.identifier.isiWOS:000082277200005-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridPatel, K=7402235263en_US
dc.identifier.scopusauthoridMakarenkova, H=6602505431en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US

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