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Article: Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning

TitleLocal inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning
Authors
Issue Date1998
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 1998, v. 196 n. 1, p. 11-23 How to Cite?
AbstractThe formation of periodic patterns is fundamental in biology. Theoretical models describing these phenomena have been proposed for feather patterning; however, no molecular candidates have been identified. Here we show that the feather tract is initiated by a continuous stripe of Shh, Fgf- 4, and Ptc expression in the epithelium, which then segregates into discrete feather primordia that are more strongly Shh and Fgf-4 positive. The primordia also become Bmp-2 and Bmp-4 positive. Bead-mediated delivery of BMPs inhibits local feather formation in contrast with the activators, SHH and FGF4, which induce feather formation. Both FGF-4 and SHH induce local expression of Bmp-4, while BMP-4 suppresses local expression of both. FGF-4 also induces Shh. Based on these findings, we propose a model that involves (1) homogeneously distributed global activators that define the field, (2) a position-dependent activator of competence that propagates across the field, and (3) local activators and inhibitors triggered in sites of individual primordia that act in a reaction-diffusion mechanism. A computer simulation model for feather pattern formation is also presented.
Persistent Identifierhttp://hdl.handle.net/10722/169528
ISSN
2015 Impact Factor: 3.155
2015 SCImago Journal Rankings: 2.554
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJung, HSen_US
dc.contributor.authorFrancisWest, PHen_US
dc.contributor.authorWidelitz, RBen_US
dc.contributor.authorJiang, TXen_US
dc.contributor.authorTingBerreth, Sen_US
dc.contributor.authorTickle, Cen_US
dc.contributor.authorWolpert, Len_US
dc.contributor.authorChuong, CMen_US
dc.date.accessioned2012-10-25T04:52:34Z-
dc.date.available2012-10-25T04:52:34Z-
dc.date.issued1998en_US
dc.identifier.citationDevelopmental Biology, 1998, v. 196 n. 1, p. 11-23en_US
dc.identifier.issn0012-1606en_US
dc.identifier.urihttp://hdl.handle.net/10722/169528-
dc.description.abstractThe formation of periodic patterns is fundamental in biology. Theoretical models describing these phenomena have been proposed for feather patterning; however, no molecular candidates have been identified. Here we show that the feather tract is initiated by a continuous stripe of Shh, Fgf- 4, and Ptc expression in the epithelium, which then segregates into discrete feather primordia that are more strongly Shh and Fgf-4 positive. The primordia also become Bmp-2 and Bmp-4 positive. Bead-mediated delivery of BMPs inhibits local feather formation in contrast with the activators, SHH and FGF4, which induce feather formation. Both FGF-4 and SHH induce local expression of Bmp-4, while BMP-4 suppresses local expression of both. FGF-4 also induces Shh. Based on these findings, we propose a model that involves (1) homogeneously distributed global activators that define the field, (2) a position-dependent activator of competence that propagates across the field, and (3) local activators and inhibitors triggered in sites of individual primordia that act in a reaction-diffusion mechanism. A computer simulation model for feather pattern formation is also presented.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_US
dc.relation.ispartofDevelopmental Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Patterningen_US
dc.subject.meshBone Morphogenetic Protein 2en_US
dc.subject.meshBone Morphogenetic Protein 4en_US
dc.subject.meshBone Morphogenetic Proteins - Pharmacologyen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFactor Ix - Metabolismen_US
dc.subject.meshFeathers - Embryologyen_US
dc.subject.meshFibroblast Growth Factor 4en_US
dc.subject.meshFibroblast Growth Factors - Metabolismen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshHedgehog Proteinsen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshPeriodicityen_US
dc.subject.meshProteins - Metabolismen_US
dc.subject.meshProto-Oncogene Proteins - Metabolismen_US
dc.subject.meshSkin - Embryologyen_US
dc.subject.meshTissue Distributionen_US
dc.subject.meshTrans-Activatorsen_US
dc.subject.meshTransforming Growth Factor Betaen_US
dc.titleLocal inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterningen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/dbio.1998.8850en_US
dc.identifier.pmid9527877en_US
dc.identifier.scopuseid_2-s2.0-0032054895en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032054895&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume196en_US
dc.identifier.issue1en_US
dc.identifier.spage11en_US
dc.identifier.epage23en_US
dc.identifier.isiWOS:000073170500002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridFrancisWest, PH=7003730165en_US
dc.identifier.scopusauthoridWidelitz, RB=6701556360en_US
dc.identifier.scopusauthoridJiang, TX=7402148591en_US
dc.identifier.scopusauthoridTingBerreth, S=6506000954en_US
dc.identifier.scopusauthoridTickle, C=7005294923en_US
dc.identifier.scopusauthoridWolpert, L=7005114065en_US
dc.identifier.scopusauthoridChuong, CM=7103159962en_US

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