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Conference Paper: Impact of skeletal-related events on overall survival in patients with metastatic carcinoma of prostate receiving androgen deprivation therapy

TitleImpact of skeletal-related events on overall survival in patients with metastatic carcinoma of prostate receiving androgen deprivation therapy
Authors
KeywordsMedical sciences
Urology and nephrology
Issue Date2012
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU
Citation
The 11th Asian Congress of Urology of the Urological Association of Asia, Pattaya, Thailand, 22-26 August 2012. In International Journal of Urology, 2012, v. 19 suppl. 1, p. 282, abstract no. MP2504P-15 How to Cite?
AbstractINTRODUCTION AND OBJECTIVES: To study the impact of skeletal-related events (SREs) on overall survival in patients with metastatic carcinoma of prostate receiving androgen deprivation therapy. METHODS: Patients with diagnosis of metastatic carcinoma of prostate and received hormonal therapy in terms of either bilateral orchidectomy or luteinizing hormone releasing hormone (LHRH) analogue injection from 2006 to 2011 in our hospital were reviewed. Demographic data, incidences of SREs and overall mortality were collected and analysed. RESULTS: There were in total 123 patients reviewed. The mean age at diagnosis was 75 years old. 58 patients had bilateral orchidectomy performed alone and 65 patients received LHRH analogue injection with 7 of them received subsequent bilateral orchidectomy. The SREs rate was 39.8% and overall mortality rate was 56.1%. The median follow up period was 21 months (Min: 1 month; Max: 125 months). Median time of survival for patients with SREs was significantly shorter than patients without SREs (25 vs 45 months, p =0.03). Timing of SREs after commencement of hormonal therapy (12 months) also have significant correlation to median survival (6 months vs 15 months, p =0.004) CONCLUSIONS: Occurrence and timing of SREs have significant correlation on median survival in patients with metastatic carcinoma of prostate. However, their causal relationships require further evaluation and elucidation. With such high prevalence of SREs and its impact on survival demonstrated in our study, every measure should be encouraged to minimize the incidence of SREs in this group of patient.
DescriptionThis journal suppl. is Special Issue: Abstracts of the 11th Asian Congress of Urology of the Urological Association of Asia, Thailand 2012
Conference Theme: New Era of Asian Urology
Abstract and Poster Presentation
Persistent Identifierhttp://hdl.handle.net/10722/169385
ISSN
2015 Impact Factor: 1.878
2015 SCImago Journal Rankings: 0.841
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, JKWen_US
dc.contributor.authorTsang, CFen_US
dc.contributor.authorWong, EMHen_US
dc.contributor.authorWong, SCWen_US
dc.contributor.authorHo, KLen_US
dc.contributor.authorYiu, MKen_US
dc.date.accessioned2012-10-18T08:53:08Z-
dc.date.available2012-10-18T08:53:08Z-
dc.date.issued2012en_US
dc.identifier.citationThe 11th Asian Congress of Urology of the Urological Association of Asia, Pattaya, Thailand, 22-26 August 2012. In International Journal of Urology, 2012, v. 19 suppl. 1, p. 282, abstract no. MP2504P-15en_US
dc.identifier.issn0919-8172-
dc.identifier.urihttp://hdl.handle.net/10722/169385-
dc.descriptionThis journal suppl. is Special Issue: Abstracts of the 11th Asian Congress of Urology of the Urological Association of Asia, Thailand 2012-
dc.descriptionConference Theme: New Era of Asian Urology-
dc.descriptionAbstract and Poster Presentation-
dc.description.abstractINTRODUCTION AND OBJECTIVES: To study the impact of skeletal-related events (SREs) on overall survival in patients with metastatic carcinoma of prostate receiving androgen deprivation therapy. METHODS: Patients with diagnosis of metastatic carcinoma of prostate and received hormonal therapy in terms of either bilateral orchidectomy or luteinizing hormone releasing hormone (LHRH) analogue injection from 2006 to 2011 in our hospital were reviewed. Demographic data, incidences of SREs and overall mortality were collected and analysed. RESULTS: There were in total 123 patients reviewed. The mean age at diagnosis was 75 years old. 58 patients had bilateral orchidectomy performed alone and 65 patients received LHRH analogue injection with 7 of them received subsequent bilateral orchidectomy. The SREs rate was 39.8% and overall mortality rate was 56.1%. The median follow up period was 21 months (Min: 1 month; Max: 125 months). Median time of survival for patients with SREs was significantly shorter than patients without SREs (25 vs 45 months, p =0.03). Timing of SREs after commencement of hormonal therapy (12 months) also have significant correlation to median survival (6 months vs 15 months, p =0.004) CONCLUSIONS: Occurrence and timing of SREs have significant correlation on median survival in patients with metastatic carcinoma of prostate. However, their causal relationships require further evaluation and elucidation. With such high prevalence of SREs and its impact on survival demonstrated in our study, every measure should be encouraged to minimize the incidence of SREs in this group of patient.-
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU-
dc.relation.ispartofInternational Journal of Urologyen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectMedical sciences-
dc.subjectUrology and nephrology-
dc.titleImpact of skeletal-related events on overall survival in patients with metastatic carcinoma of prostate receiving androgen deprivation therapyen_US
dc.typeConference_Paperen_US
dc.identifier.emailTsang, CF: ivantcf@HKUSUA.hku.hken_US
dc.identifier.emailWong, EMH: h9945812@HKUSUA.hku.hken_US
dc.identifier.emailWong, SCW: wongcws@hku.hk-
dc.identifier.emailHo, KL: hkl218@hkucc.hku.hk-
dc.identifier.emailYiu, MK: pmkyiu@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1442-2042.2012.03167.x-
dc.identifier.hkuros212263en_US
dc.identifier.volume19en_US
dc.identifier.issuesuppl. 1en_US
dc.identifier.spage282en_US
dc.identifier.epage282en_US
dc.identifier.isiWOS:000308130600002-
dc.publisher.placeAustralia-
dc.description.otherThe 11th Asian Congress of Urology of the Urological Association of Asia, Pattaya, Thailand, 22-26 August 2012. In International Journal of Urology, 2012, v. 19 suppl. 1, p. 282, abstract no. MP2504P-15-

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