File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Effect of osteoporotic fractures on overall survival in patients with non-metastatic prostatic cancer having androgen deprivation therapy

TitleEffect of osteoporotic fractures on overall survival in patients with non-metastatic prostatic cancer having androgen deprivation therapy
Authors
KeywordsMedical sciences
Urology and nephrology
Issue Date2012
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU
Citation
The 11th Asian Congress of Urology of the Urological Association of Asia, Pattaya, Thailand, 22-26 August 2012. In International Journal of Urology, 2012, v. 19 suppl. 1, p. 254, abstract no. OP2504P-04 How to Cite?
AbstractINTRODUCTION AND OBJECTIVES: Patients with prostatic cancer who received androgen deprivation therapy (ADT) have high risk of developing osteoporosis with prevalence as high as 80% after 10 years of ADT. These patients have higher risk in developing osteoporotic fracture, which may result in significant morbidity and mortality. We study the correlations of incidence of osteoporotic fractures on overall survival in patients with non-metastatic prostatic cancer receiving ADT. METHODS: We retrospectively reviewed the records of 118 patients with non-metastatic prostatic cancer who received ADT in terms of bilateral simple orchidectomy or luteinizing hormone releasing hormone analogue (LHRHa) injection from 2006-2011. Demographics, evidence of bone metastasis, incidence of osteoporotic fracture and overall mortality were analysed. RESULTS: Of the 118 patients, 63 underwent bilateral orchidectomy and 50 received LHRHa. 5 patients initially on LHRHa subsequently underwent bilateral simple orchidectomy. 88 had bone scan to confirm the absence of bone metastasis, with the rest showed no clinical evidence of bone metastases. The median follow-up was 32 months. Group 1 included 106 patients without fractures, and Group 2 included 12 patients who developed osteoporotic fractures, in which 3 were vertebral fractures and 9 were hip fractures. The two groups were demographically similar, with median age 77.5 vs. 74.2, p=0.4. The median survival of patients of Group 1 and 2 was 26 months (1-82 months) and 40 months (15-86 months) respectively. There is no statistically difference in overall survival of these two groups of patients (p=0.679). CONCLUSIONS: Osteoporotic fractures in non-metastatic prostatic cancer patients on ADT are not associated with the overall survival. Prevention of osteoporotic fractures may improve patientÕs quality of life and decrease morbidity but does not affect overall survival.
DescriptionThis journal suppl. is Special Issue: Abstracts of the 11th Asian Congress of Urology of the Urological Association of Asia, Thailand 2012
Conference Theme: New Era of Asian Urology
Abstract and Oral Presentation
Persistent Identifierhttp://hdl.handle.net/10722/169381
ISSN
2015 Impact Factor: 1.878
2015 SCImago Journal Rankings: 0.841
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, TCTen_US
dc.contributor.authorWong, JKWen_US
dc.contributor.authorTsang, CFen_US
dc.contributor.authorWong, EMHen_US
dc.contributor.authorWong, SCWen_US
dc.contributor.authorHo, KLen_US
dc.contributor.authorYiu, MKen_US
dc.date.accessioned2012-10-18T08:53:02Z-
dc.date.available2012-10-18T08:53:02Z-
dc.date.issued2012en_US
dc.identifier.citationThe 11th Asian Congress of Urology of the Urological Association of Asia, Pattaya, Thailand, 22-26 August 2012. In International Journal of Urology, 2012, v. 19 suppl. 1, p. 254, abstract no. OP2504P-04en_US
dc.identifier.issn0919-8172-
dc.identifier.urihttp://hdl.handle.net/10722/169381-
dc.descriptionThis journal suppl. is Special Issue: Abstracts of the 11th Asian Congress of Urology of the Urological Association of Asia, Thailand 2012-
dc.descriptionConference Theme: New Era of Asian Urology-
dc.descriptionAbstract and Oral Presentation-
dc.description.abstractINTRODUCTION AND OBJECTIVES: Patients with prostatic cancer who received androgen deprivation therapy (ADT) have high risk of developing osteoporosis with prevalence as high as 80% after 10 years of ADT. These patients have higher risk in developing osteoporotic fracture, which may result in significant morbidity and mortality. We study the correlations of incidence of osteoporotic fractures on overall survival in patients with non-metastatic prostatic cancer receiving ADT. METHODS: We retrospectively reviewed the records of 118 patients with non-metastatic prostatic cancer who received ADT in terms of bilateral simple orchidectomy or luteinizing hormone releasing hormone analogue (LHRHa) injection from 2006-2011. Demographics, evidence of bone metastasis, incidence of osteoporotic fracture and overall mortality were analysed. RESULTS: Of the 118 patients, 63 underwent bilateral orchidectomy and 50 received LHRHa. 5 patients initially on LHRHa subsequently underwent bilateral simple orchidectomy. 88 had bone scan to confirm the absence of bone metastasis, with the rest showed no clinical evidence of bone metastases. The median follow-up was 32 months. Group 1 included 106 patients without fractures, and Group 2 included 12 patients who developed osteoporotic fractures, in which 3 were vertebral fractures and 9 were hip fractures. The two groups were demographically similar, with median age 77.5 vs. 74.2, p=0.4. The median survival of patients of Group 1 and 2 was 26 months (1-82 months) and 40 months (15-86 months) respectively. There is no statistically difference in overall survival of these two groups of patients (p=0.679). CONCLUSIONS: Osteoporotic fractures in non-metastatic prostatic cancer patients on ADT are not associated with the overall survival. Prevention of osteoporotic fractures may improve patientÕs quality of life and decrease morbidity but does not affect overall survival.-
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU-
dc.relation.ispartofInternational Journal of Urologyen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectMedical sciences-
dc.subjectUrology and nephrology-
dc.titleEffect of osteoporotic fractures on overall survival in patients with non-metastatic prostatic cancer having androgen deprivation therapyen_US
dc.typeConference_Paperen_US
dc.identifier.emailLai, TCT: lctt@HKUSUA.hku.hken_US
dc.identifier.emailTsang, CF: ivantcf@HKUSUA.hku.hken_US
dc.identifier.emailWong, EMH: h9945812@HKUSUA.hku.hk-
dc.identifier.emailWong, SCW: wongcws@hku.hk-
dc.identifier.emailHo, KL: hkl218@hkucc.hku.hk-
dc.identifier.emailYiu, MK: pmkyiu@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1442-2042.2012.03167.x-
dc.identifier.hkuros212259en_US
dc.identifier.volume19en_US
dc.identifier.issuesuppl. 1en_US
dc.identifier.spage254en_US
dc.identifier.epage254en_US
dc.identifier.isiWOS:000308130600002-
dc.publisher.placeAustralia-
dc.description.otherThe 11th Asian Congress of Urology of the Urological Association of Asia, Pattaya, Thailand, 22-26 August 2012. In International Journal of Urology, 2012, v. 19 suppl. 1, p. 254, abstract no. OP2504P-04-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats