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Article: The neural basis special for processing fearful expression

TitleThe neural basis special for processing fearful expression
Authors
KeywordsAmygdala
Emotions
Frontal Lobe
Gyrus Cinguli
Issue Date2005
Citation
Chinese Journal Of Neurology, 2005, v. 38 n. 12, p. 769-772 How to Cite?
AbstractObjective: To find out the profile of perception of emotion in patients with lesions in bilateral cingulate gyrus, bilateral hippocampus and prefrontal cortex, and to test which of these areas are involved in the special network of fear processing. Methods: A six-basic-emotion continum with 30 morphed emotional faces across happiness-surprise-fear-sadness-disgust-anger-happiness was developed. A labeling task with these morphed emotional faces was administered to measure the ability of recognizing the emotional expressions. Results: A group of 12 cases with prefrontal lesions, showed a gross impairment of recognition of expressions across all 6 basic emotions (the correct scores for 6 basic emotions are 18.41, 16.58, 11.08, 15.67, 12.92 and 15.33 respectively, P < 0.01). Case 1 (with lesion in bilateral hippocampus) showed normal ability in recognizing all emotional faces, but an obvious impairment of episodic memory. Case 2 (with bilateral anterior cingulate gyrus lesions and a very small lesion in the right amygdale) manifested a robust deficit in recognition of fearful expressions (the correct score for fear is 4.67, P < 0.01 in comparison with normal and schizophrenic controls) sparing other emotions except disgust processing (barely borderline different from normal controls). Many cases had shown that unilateral lesion in the amygdala, whether left or right, was not enough to impair fear processing. Although case 2 had a very small lesion in the right amygdala, the result of his performance suggested that bilateral cingulate gyrus, like bilateral amygdala, were selectively involved in fear processing. Conclusions: It is suggested that bilateral amygdala and cingulate gyrus be all selectively involved in fear processing (in parallel or at different levels), while the prefrontal cortex functions as unselective processor for processing of all emotions. It is also possible that hippocampus be involved in the episodic memory, but not in emotional process.
Persistent Identifierhttp://hdl.handle.net/10722/169003
ISSN
2015 SCImago Journal Rankings: 0.103
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Ken_US
dc.contributor.authorLee, TMCen_US
dc.contributor.authorGu, JHen_US
dc.contributor.authorDong, Yen_US
dc.contributor.authorXia, HTen_US
dc.contributor.authorFeng, ZHen_US
dc.contributor.authorMeng, Yen_US
dc.contributor.authorYin, SJen_US
dc.date.accessioned2012-10-08T03:40:40Z-
dc.date.available2012-10-08T03:40:40Z-
dc.date.issued2005en_US
dc.identifier.citationChinese Journal Of Neurology, 2005, v. 38 n. 12, p. 769-772en_US
dc.identifier.issn1006-7876en_US
dc.identifier.urihttp://hdl.handle.net/10722/169003-
dc.description.abstractObjective: To find out the profile of perception of emotion in patients with lesions in bilateral cingulate gyrus, bilateral hippocampus and prefrontal cortex, and to test which of these areas are involved in the special network of fear processing. Methods: A six-basic-emotion continum with 30 morphed emotional faces across happiness-surprise-fear-sadness-disgust-anger-happiness was developed. A labeling task with these morphed emotional faces was administered to measure the ability of recognizing the emotional expressions. Results: A group of 12 cases with prefrontal lesions, showed a gross impairment of recognition of expressions across all 6 basic emotions (the correct scores for 6 basic emotions are 18.41, 16.58, 11.08, 15.67, 12.92 and 15.33 respectively, P < 0.01). Case 1 (with lesion in bilateral hippocampus) showed normal ability in recognizing all emotional faces, but an obvious impairment of episodic memory. Case 2 (with bilateral anterior cingulate gyrus lesions and a very small lesion in the right amygdale) manifested a robust deficit in recognition of fearful expressions (the correct score for fear is 4.67, P < 0.01 in comparison with normal and schizophrenic controls) sparing other emotions except disgust processing (barely borderline different from normal controls). Many cases had shown that unilateral lesion in the amygdala, whether left or right, was not enough to impair fear processing. Although case 2 had a very small lesion in the right amygdala, the result of his performance suggested that bilateral cingulate gyrus, like bilateral amygdala, were selectively involved in fear processing. Conclusions: It is suggested that bilateral amygdala and cingulate gyrus be all selectively involved in fear processing (in parallel or at different levels), while the prefrontal cortex functions as unselective processor for processing of all emotions. It is also possible that hippocampus be involved in the episodic memory, but not in emotional process.en_US
dc.languageengen_US
dc.relation.ispartofChinese Journal of Neurologyen_US
dc.subjectAmygdalaen_US
dc.subjectEmotionsen_US
dc.subjectFrontal Lobeen_US
dc.subjectGyrus Cingulien_US
dc.titleThe neural basis special for processing fearful expressionen_US
dc.typeArticleen_US
dc.identifier.emailLee, TMC:tmclee@hku.hken_US
dc.identifier.authorityLee, TMC=rp00564en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33644912628en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644912628&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume38en_US
dc.identifier.issue12en_US
dc.identifier.spage769en_US
dc.identifier.epage772en_US
dc.identifier.scopusauthoridWang, K=7501399461en_US
dc.identifier.scopusauthoridLee, TMC=7501437381en_US
dc.identifier.scopusauthoridGu, JH=7403130053en_US
dc.identifier.scopusauthoridDong, Y=55244663500en_US
dc.identifier.scopusauthoridXia, HT=12778845200en_US
dc.identifier.scopusauthoridFeng, ZH=15061090600en_US
dc.identifier.scopusauthoridMeng, Y=16425963400en_US
dc.identifier.scopusauthoridYin, SJ=55106518000en_US

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