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Article: Functional and cortical adaptations to central vision loss

TitleFunctional and cortical adaptations to central vision loss
Authors
Issue Date2005
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=VNS
Citation
Visual Neuroscience, 2005, v. 22 n. 2, p. 187-201 How to Cite?
AbstractAge-related macular degeneration (AMD), affecting the retina, afflicts one out of ten people aged 80 years or older in the United States. AMD often results in vision loss to the central 15-20 deg of the visual field (i.e. central scotoma), and frequently afflicts both eyes. In most cases, when the central scotoma includes the fovea, patients will adopt an eccentric preferred retinal locus (PRL) for fixation. The onset of a central scotoma results in the absence of retinal inputs to corresponding regions of retinotopically mapped visual cortex. Animal studies have shown evidence for reorganization in adult mammals for such cortical areas following experimentally induced central scotomata. However, it is still unknown whether reorganization occurs in primary visual cortex (V1) of AMD patients. Nor is it known whether the adoption of a PRL corresponds to changes to the retinotopic mapping of V1. Two recent advances hold out the promise for addressing these issues and for contributing to the rehabilitation of AMD patients: improved methods for assessing visual function across the fields of AMD patients using the scanning laser ophthalmoscope, and the advent of brain-imaging methods for studying retinotopic mapping in humans. For the most part, specialists in these two areas come from different disciplines and communities, with few opportunities to interact. The purpose of this review is to summarize key findings on both the clinical and neuroscience issues related to questions about visual adaptation in AMD patients. Copyright © 2005 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/168989
ISSN
2015 Impact Factor: 1.871
2015 SCImago Journal Rankings: 1.231
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, SHen_US
dc.contributor.authorLegge, GEen_US
dc.date.accessioned2012-10-08T03:40:31Z-
dc.date.available2012-10-08T03:40:31Z-
dc.date.issued2005en_US
dc.identifier.citationVisual Neuroscience, 2005, v. 22 n. 2, p. 187-201en_US
dc.identifier.issn0952-5238en_US
dc.identifier.urihttp://hdl.handle.net/10722/168989-
dc.description.abstractAge-related macular degeneration (AMD), affecting the retina, afflicts one out of ten people aged 80 years or older in the United States. AMD often results in vision loss to the central 15-20 deg of the visual field (i.e. central scotoma), and frequently afflicts both eyes. In most cases, when the central scotoma includes the fovea, patients will adopt an eccentric preferred retinal locus (PRL) for fixation. The onset of a central scotoma results in the absence of retinal inputs to corresponding regions of retinotopically mapped visual cortex. Animal studies have shown evidence for reorganization in adult mammals for such cortical areas following experimentally induced central scotomata. However, it is still unknown whether reorganization occurs in primary visual cortex (V1) of AMD patients. Nor is it known whether the adoption of a PRL corresponds to changes to the retinotopic mapping of V1. Two recent advances hold out the promise for addressing these issues and for contributing to the rehabilitation of AMD patients: improved methods for assessing visual function across the fields of AMD patients using the scanning laser ophthalmoscope, and the advent of brain-imaging methods for studying retinotopic mapping in humans. For the most part, specialists in these two areas come from different disciplines and communities, with few opportunities to interact. The purpose of this review is to summarize key findings on both the clinical and neuroscience issues related to questions about visual adaptation in AMD patients. Copyright © 2005 Cambridge University Press.en_US
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=VNSen_US
dc.relation.ispartofVisual Neuroscienceen_US
dc.subject.meshAdaptation, Biological - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshMacular Degeneration - Physiopathologyen_US
dc.subject.meshNeuronal Plasticity - Physiologyen_US
dc.subject.meshRetina - Physiologyen_US
dc.subject.meshScotoma - Physiopathologyen_US
dc.subject.meshVisual Cortex - Physiologyen_US
dc.titleFunctional and cortical adaptations to central vision lossen_US
dc.typeArticleen_US
dc.identifier.emailCheung, SH:singhang@hku.hken_US
dc.identifier.authorityCheung, SH=rp00590en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1017/S0952523805222071en_US
dc.identifier.pmid15935111-
dc.identifier.pmcidPMC1255967-
dc.identifier.scopuseid_2-s2.0-21244443725en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21244443725&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue2en_US
dc.identifier.spage187en_US
dc.identifier.epage201en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, SH=7202473508en_US
dc.identifier.scopusauthoridLegge, GE=7005064208en_US
dc.identifier.citeulike1248464-

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