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Article: Effect of ecstasy use on neuropsychological function: A study in Hong Kong

TitleEffect of ecstasy use on neuropsychological function: A study in Hong Kong
Authors
Issue Date2005
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htm
Citation
Psychopharmacology, 2005, v. 179 n. 3, p. 620-628 How to Cite?
AbstractRationale: Previous studies on the effects of ecstasy on neuropsychological performance have often recruited small sample sizes. Objectives: The present study was conducted to validate previous findings regarding the effects of ecstasy consumption on neuropsychological performance. Method: A comprehensive neuropsychological investigation was conducted in 100 abstinent ecstasy users and 100 matched non-user counterparts on standardized measures of working memory, verbal and non-verbal memory, verbal and figural fluency, and selective and switching attention. Results: Abstinent ecstasy users were impaired on verbal and non-verbal memory, complex attention, and verbal fluency, but not on working memory, relative to their non-user counterparts. Of particular interest was the fact that abstinent ecstasy users performed better on figural fluency relative to their non-user counterparts. In addition, only cumulative ecstasy consumption correlated with neuropsychological performances among abstinent ecstasy users. Canonical discriminant analysis yielded verbal and visual memory, switching attention, and verbal fluency as potential core neuropsychological variables for differentiating abstinent ecstasy users from non-users. Levels of depression and general non-verbal intelligence, as measured by the Beck Depression Inventory and the test of non-verbal Intelligence, respectively, were not likely to affect these findings, since these measures were matched between ecstasy users and non-users. Conclusions: These findings suggest that previous ecstasy consumption can affect a wide range of neuropsychological performance, though figural fluency may be subsequently enhanced as a result of the phenomenon of "cortical disinhibition." Furthermore, measures of verbal and visual memory, switching attention, and verbal fluency may be particularly useful for differentiating abstinent ecstasy users from non-users. © Springer-Verlag 2005.
Persistent Identifierhttp://hdl.handle.net/10722/168985
ISSN
2015 Impact Factor: 3.54
2015 SCImago Journal Rankings: 1.687
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYip, JTHen_US
dc.contributor.authorLee, TMCen_US
dc.date.accessioned2012-10-08T03:40:29Z-
dc.date.available2012-10-08T03:40:29Z-
dc.date.issued2005en_US
dc.identifier.citationPsychopharmacology, 2005, v. 179 n. 3, p. 620-628en_US
dc.identifier.issn0033-3158en_US
dc.identifier.urihttp://hdl.handle.net/10722/168985-
dc.description.abstractRationale: Previous studies on the effects of ecstasy on neuropsychological performance have often recruited small sample sizes. Objectives: The present study was conducted to validate previous findings regarding the effects of ecstasy consumption on neuropsychological performance. Method: A comprehensive neuropsychological investigation was conducted in 100 abstinent ecstasy users and 100 matched non-user counterparts on standardized measures of working memory, verbal and non-verbal memory, verbal and figural fluency, and selective and switching attention. Results: Abstinent ecstasy users were impaired on verbal and non-verbal memory, complex attention, and verbal fluency, but not on working memory, relative to their non-user counterparts. Of particular interest was the fact that abstinent ecstasy users performed better on figural fluency relative to their non-user counterparts. In addition, only cumulative ecstasy consumption correlated with neuropsychological performances among abstinent ecstasy users. Canonical discriminant analysis yielded verbal and visual memory, switching attention, and verbal fluency as potential core neuropsychological variables for differentiating abstinent ecstasy users from non-users. Levels of depression and general non-verbal intelligence, as measured by the Beck Depression Inventory and the test of non-verbal Intelligence, respectively, were not likely to affect these findings, since these measures were matched between ecstasy users and non-users. Conclusions: These findings suggest that previous ecstasy consumption can affect a wide range of neuropsychological performance, though figural fluency may be subsequently enhanced as a result of the phenomenon of "cortical disinhibition." Furthermore, measures of verbal and visual memory, switching attention, and verbal fluency may be particularly useful for differentiating abstinent ecstasy users from non-users. © Springer-Verlag 2005.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htmen_US
dc.relation.ispartofPsychopharmacologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAttention - Drug Effects - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMemory - Drug Effects - Physiologyen_US
dc.subject.meshMemory Disorders - Chemically Induced - Psychologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshN-Methyl-3,4-Methylenedioxyamphetamine - Adverse Effects - Pharmacologyen_US
dc.subject.meshNeuropsychological Tests - Statistics & Numerical Dataen_US
dc.titleEffect of ecstasy use on neuropsychological function: A study in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailLee, TMC:tmclee@hku.hken_US
dc.identifier.authorityLee, TMC=rp00564en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00213-004-2083-4en_US
dc.identifier.pmid15650845-
dc.identifier.scopuseid_2-s2.0-18744367542en_US
dc.identifier.hkuros102201-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18744367542&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume179en_US
dc.identifier.issue3en_US
dc.identifier.spage620en_US
dc.identifier.epage628en_US
dc.identifier.isiWOS:000228850000013-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridYip, JTH=7006651184en_US
dc.identifier.scopusauthoridLee, TMC=7501437381en_US

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