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Conference Paper: Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration
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TitleComparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration
 
AuthorsLi, G4
Zhang, XA4
Wang, H4
Wang, X4
Meng, CL4
Chan, CY4
Yew, DTW4
Tsang, KS4
Li, K4
Tsai, SN4
Ngai, SM4
Han, ZC3
Lin, MCM2
He, ML4
Kung, HF1 4
 
Issue Date2011
 
CitationAdvances In Experimental Medicine And Biology, 2011, v. 720, p. 51-68 [How to Cite?]
DOI: http://dx.doi.org/10.1007/978-1-4614-0254-1_5
 
AbstractUmbilical cord (UC) and placenta (P) have been suggested as alternatives to bone marrow (BM) as sources of mesenchymal stem cells (MSC) for cell therapy, with both UC- and P-MSC possess immunophenotypic and functional characteristics similar to BM-MSC. However, under defined conditions, the migration capacity of BM- and P-MSC was found to be 5.9- and 3.2-folds higher than that of UC-MSC, respectively. By the use of 2-DE and combined MS and MS/MS analysis, six differentially expressed proteins were identified among these MSC samples, with five of them known to be involved in cell migration as migration enhancing or inhibiting proteins. Interestingly, the expression levels of those proteins reflect perfectly the migration capacity of corresponding MSC, which is also proved by in vitro overexpression and silencing techniques. Our study indicates that a bunch of migration-related proteins are pivotal in governing the migration capacity of MSC. © 2011 Springer Science+Business Media, LLC.
 
ISSN0065-2598
2013 SCImago Journal Rankings: 0.973
 
DOIhttp://dx.doi.org/10.1007/978-1-4614-0254-1_5
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, G
 
dc.contributor.authorZhang, XA
 
dc.contributor.authorWang, H
 
dc.contributor.authorWang, X
 
dc.contributor.authorMeng, CL
 
dc.contributor.authorChan, CY
 
dc.contributor.authorYew, DTW
 
dc.contributor.authorTsang, KS
 
dc.contributor.authorLi, K
 
dc.contributor.authorTsai, SN
 
dc.contributor.authorNgai, SM
 
dc.contributor.authorHan, ZC
 
dc.contributor.authorLin, MCM
 
dc.contributor.authorHe, ML
 
dc.contributor.authorKung, HF
 
dc.date.accessioned2012-10-08T03:35:22Z
 
dc.date.available2012-10-08T03:35:22Z
 
dc.date.issued2011
 
dc.description.abstractUmbilical cord (UC) and placenta (P) have been suggested as alternatives to bone marrow (BM) as sources of mesenchymal stem cells (MSC) for cell therapy, with both UC- and P-MSC possess immunophenotypic and functional characteristics similar to BM-MSC. However, under defined conditions, the migration capacity of BM- and P-MSC was found to be 5.9- and 3.2-folds higher than that of UC-MSC, respectively. By the use of 2-DE and combined MS and MS/MS analysis, six differentially expressed proteins were identified among these MSC samples, with five of them known to be involved in cell migration as migration enhancing or inhibiting proteins. Interestingly, the expression levels of those proteins reflect perfectly the migration capacity of corresponding MSC, which is also proved by in vitro overexpression and silencing techniques. Our study indicates that a bunch of migration-related proteins are pivotal in governing the migration capacity of MSC. © 2011 Springer Science+Business Media, LLC.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAdvances In Experimental Medicine And Biology, 2011, v. 720, p. 51-68 [How to Cite?]
DOI: http://dx.doi.org/10.1007/978-1-4614-0254-1_5
 
dc.identifier.doihttp://dx.doi.org/10.1007/978-1-4614-0254-1_5
 
dc.identifier.epage68
 
dc.identifier.issn0065-2598
2013 SCImago Journal Rankings: 0.973
 
dc.identifier.scopuseid_2-s2.0-80053910493
 
dc.identifier.spage51
 
dc.identifier.urihttp://hdl.handle.net/10722/168877
 
dc.identifier.volume720
 
dc.languageeng
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAdvances in Experimental Medicine and Biology
 
dc.relation.referencesReferences in Scopus
 
dc.titleComparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration
 
dc.typeConference_Paper
 
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Author Affiliations
  1. Sun Yat-Sen University Cancer Center
  2. The University of Hong Kong
  3. Institute of Hematology and Blood Disease Hospital
  4. Chinese University of Hong Kong