Conference Paper: Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration

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Publisher Website: 10.1007/978-1-4614-0254-1_5
Scopus: eid_2-s2.0-80053910493

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Title	Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration
Authors	Li, G4 Zhang, XA4 Wang, H4 Wang, X4 Meng, CL4 Chan, CY4 Yew, DTW4 Tsang, KS4 Li, K4 Tsai, SN4 Ngai, SM4 Han, ZC3 Lin, MCM2 He, ML4 Kung, HF1 4
Issue Date	2011
Citation	Advances In Experimental Medicine And Biology, 2011, v. 720, p. 51-68 [How to Cite?] DOI: http://dx.doi.org/10.1007/978-1-4614-0254-1_5
Abstract	Umbilical cord (UC) and placenta (P) have been suggested as alternatives to bone marrow (BM) as sources of mesenchymal stem cells (MSC) for cell therapy, with both UC- and P-MSC possess immunophenotypic and functional characteristics similar to BM-MSC. However, under defined conditions, the migration capacity of BM- and P-MSC was found to be 5.9- and 3.2-folds higher than that of UC-MSC, respectively. By the use of 2-DE and combined MS and MS/MS analysis, six differentially expressed proteins were identified among these MSC samples, with five of them known to be involved in cell migration as migration enhancing or inhibiting proteins. Interestingly, the expression levels of those proteins reflect perfectly the migration capacity of corresponding MSC, which is also proved by in vitro overexpression and silencing techniques. Our study indicates that a bunch of migration-related proteins are pivotal in governing the migration capacity of MSC. © 2011 Springer Science+Business Media, LLC.
ISSN	0065-2598 2011 Impact Factor: 1.093 2011 SCImago Journal Rankings: 0.177
DOI	http://dx.doi.org/10.1007/978-1-4614-0254-1_5
References	References in Scopus

DC Field	Value
dc.contributor.author	Li, G
dc.contributor.author	Zhang, XA
dc.contributor.author	Wang, H
dc.contributor.author	Wang, X
dc.contributor.author	Meng, CL
dc.contributor.author	Chan, CY
dc.contributor.author	Yew, DTW
dc.contributor.author	Tsang, KS
dc.contributor.author	Li, K
dc.contributor.author	Tsai, SN
dc.contributor.author	Ngai, SM
dc.contributor.author	Han, ZC
dc.contributor.author	Lin, MCM
dc.contributor.author	He, ML
dc.contributor.author	Kung, HF
dc.date.accessioned	2012-10-08T03:35:22Z
dc.date.available	2012-10-08T03:35:22Z
dc.date.issued	2011
dc.description.abstract	Umbilical cord (UC) and placenta (P) have been suggested as alternatives to bone marrow (BM) as sources of mesenchymal stem cells (MSC) for cell therapy, with both UC- and P-MSC possess immunophenotypic and functional characteristics similar to BM-MSC. However, under defined conditions, the migration capacity of BM- and P-MSC was found to be 5.9- and 3.2-folds higher than that of UC-MSC, respectively. By the use of 2-DE and combined MS and MS/MS analysis, six differentially expressed proteins were identified among these MSC samples, with five of them known to be involved in cell migration as migration enhancing or inhibiting proteins. Interestingly, the expression levels of those proteins reflect perfectly the migration capacity of corresponding MSC, which is also proved by in vitro overexpression and silencing techniques. Our study indicates that a bunch of migration-related proteins are pivotal in governing the migration capacity of MSC. © 2011 Springer Science+Business Media, LLC.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Advances In Experimental Medicine And Biology, 2011, v. 720, p. 51-68 [How to Cite?] DOI: http://dx.doi.org/10.1007/978-1-4614-0254-1_5
dc.identifier.doi	http://dx.doi.org/10.1007/978-1-4614-0254-1_5
dc.identifier.epage	68
dc.identifier.issn	0065-2598 2011 Impact Factor: 1.093 2011 SCImago Journal Rankings: 0.177
dc.identifier.scopus	eid_2-s2.0-80053910493
dc.identifier.spage	51
dc.identifier.uri	http://hdl.handle.net/10722/168877
dc.identifier.volume	720
dc.language	eng
dc.publisher.place	United States
dc.relation.ispartof	Advances in Experimental Medicine and Biology
dc.relation.references	References in Scopus
dc.title	Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration
dc.type	Conference_Paper

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Author Affiliations

Sun Yat-Sen University Cancer Center
The University of Hong Kong
Institute of Hematology and Blood Disease Hospital
Chinese University of Hong Kong

Conference Paper: Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration

The HKU Scholars Hub has contact details for these author(s).