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Article: A fascinating journey into history: Exploration of the world of isonitriles en route to complex amides

TitleA fascinating journey into history: Exploration of the world of isonitriles en route to complex amides
Authors
Issue Date2012
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie - International Edition, 2012, v. 51 n. 12, p. 2834-2848 How to Cite?
AbstractWe describe herein our recent explorations in the field of isonitrile chemistry. An array of broadly useful coupling methodologies has been developed for the formation of peptidyl and glycopeptidyl amide bonds. We further describe the application of these methods to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles. New take on an old classic: Recent explorations in the field of isonitrile chemistry led to the development of an array of broadly useful coupling methods for the formation of peptidyl and glycopeptidyl amide bonds. The methods were applied to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles (see scheme; FCMA=formimidate carboxylate mixed anhydride). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/168647
ISSN
2015 Impact Factor: 11.709
2015 SCImago Journal Rankings: 6.229
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWilson, RMen_US
dc.contributor.authorStockdill, JLen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorVadola, PAen_US
dc.contributor.authorPark, PKen_US
dc.contributor.authorWang, Pen_US
dc.contributor.authorDanishefsky, SJen_US
dc.date.accessioned2012-10-08T03:23:57Z-
dc.date.available2012-10-08T03:23:57Z-
dc.date.issued2012en_US
dc.identifier.citationAngewandte Chemie - International Edition, 2012, v. 51 n. 12, p. 2834-2848en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttp://hdl.handle.net/10722/168647-
dc.description.abstractWe describe herein our recent explorations in the field of isonitrile chemistry. An array of broadly useful coupling methodologies has been developed for the formation of peptidyl and glycopeptidyl amide bonds. We further describe the application of these methods to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles. New take on an old classic: Recent explorations in the field of isonitrile chemistry led to the development of an array of broadly useful coupling methods for the formation of peptidyl and glycopeptidyl amide bonds. The methods were applied to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles (see scheme; FCMA=formimidate carboxylate mixed anhydride). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_US
dc.relation.ispartofAngewandte Chemie - International Editionen_US
dc.subject.meshAmides - Chemistryen_US
dc.subject.meshCarboxylic Acids - Chemistryen_US
dc.subject.meshCyclosporine - Chemical Synthesis - Chemistryen_US
dc.subject.meshGlycopeptides - Chemical Synthesis - Chemistryen_US
dc.subject.meshHeterocyclic Compounds - Chemical Synthesis - Chemistryen_US
dc.subject.meshNitriles - Chemistryen_US
dc.subject.meshPeptides - Chemical Synthesis - Chemistryen_US
dc.subject.meshStereoisomerismen_US
dc.subject.meshSulfhydryl Compounds - Chemistryen_US
dc.titleA fascinating journey into history: Exploration of the world of isonitriles en route to complex amidesen_US
dc.typeArticleen_US
dc.identifier.emailLi, X:xuechenl@hku.hken_US
dc.identifier.authorityLi, X=rp00742en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/anie.201106628en_US
dc.identifier.pmid22368033-
dc.identifier.scopuseid_2-s2.0-84863230520en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863230520&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume51en_US
dc.identifier.issue12en_US
dc.identifier.spage2834en_US
dc.identifier.epage2848en_US
dc.identifier.isiWOS:000301430700005-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridWilson, RM=8884438700en_US
dc.identifier.scopusauthoridStockdill, JL=16643901200en_US
dc.identifier.scopusauthoridWu, X=26650236700en_US
dc.identifier.scopusauthoridLi, X=24168958800en_US
dc.identifier.scopusauthoridVadola, PA=26647922100en_US
dc.identifier.scopusauthoridPark, PK=7202425180en_US
dc.identifier.scopusauthoridWang, P=35220801200en_US
dc.identifier.scopusauthoridDanishefsky, SJ=7202925243en_US

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