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Article: Ethanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish

TitleEthanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish
Authors
Issue Date2012
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0272-4340
Citation
Cellular And Molecular Neurobiology, 2012, v. 32 n. 1, p. 27-40 How to Cite?
Abstract
In an attempt to understand the neuroprotective effect of Fructus Alpinia oxyphylla (AOE) and to elucidate its underlying mechanism of action, the ethanolic extract of AOE was investigated using zebrafish and PC12 cell models. AOE prevented and restored 6-hydroxydopamine (6-OHDA)-induced dopaminergic (DA) neuron degeneration and attenuated a deficit of locomotor activity in a zebrafish (Danio rerio) model of Parkinson's disease (PD). Treatment with AOE increased the viability of 6-OHDAtreated PC12 cells in vitro in a dose-dependent manner by attenuating cellular apoptosis. However, protocatechuic acid (PCA) and chrysin, two known polyphenol components of AOE, could not reproduce the neuroprotective activity of AOE in the PD zebrafish or PC12 cell models. A mechanistic study found that the protective effect of AOE against 6-OHDA-induced neuronal injury involved antiinflammatory action (down-regulation of gene expression of IL-1β and TNF-α) and anti-oxidative action (inhibition of NO production and iNOS expression in PC12 cells). Moreover, the PI3K-AKT pathway might be part of the mechanism of neuroprotection of AOE. The results of this research are expected to provide a scientific rationale for the use of AOE in the treatment of PD. However, it is important that the active components that contribute to the neuroprotective action of AOE are identified and characterized. © Springer Science+Business Media, LLC 2011.
Persistent Identifierhttp://hdl.handle.net/10722/168606
ISSN
2013 Impact Factor: 2.201
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. University of Macau
  3. Jinan University
  4. Chinese University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorZhang, ZJen_US
dc.contributor.authorCheang, LCVen_US
dc.contributor.authorWang, MWen_US
dc.contributor.authorLi, GHen_US
dc.contributor.authorChu, IKen_US
dc.contributor.authorLin, ZXen_US
dc.contributor.authorLee, SMYen_US
dc.date.accessioned2012-10-08T03:21:28Z-
dc.date.available2012-10-08T03:21:28Z-
dc.date.issued2012en_US
dc.identifier.citationCellular And Molecular Neurobiology, 2012, v. 32 n. 1, p. 27-40en_US
dc.identifier.issn0272-4340en_US
dc.identifier.urihttp://hdl.handle.net/10722/168606-
dc.description.abstractIn an attempt to understand the neuroprotective effect of Fructus Alpinia oxyphylla (AOE) and to elucidate its underlying mechanism of action, the ethanolic extract of AOE was investigated using zebrafish and PC12 cell models. AOE prevented and restored 6-hydroxydopamine (6-OHDA)-induced dopaminergic (DA) neuron degeneration and attenuated a deficit of locomotor activity in a zebrafish (Danio rerio) model of Parkinson's disease (PD). Treatment with AOE increased the viability of 6-OHDAtreated PC12 cells in vitro in a dose-dependent manner by attenuating cellular apoptosis. However, protocatechuic acid (PCA) and chrysin, two known polyphenol components of AOE, could not reproduce the neuroprotective activity of AOE in the PD zebrafish or PC12 cell models. A mechanistic study found that the protective effect of AOE against 6-OHDA-induced neuronal injury involved antiinflammatory action (down-regulation of gene expression of IL-1β and TNF-α) and anti-oxidative action (inhibition of NO production and iNOS expression in PC12 cells). Moreover, the PI3K-AKT pathway might be part of the mechanism of neuroprotection of AOE. The results of this research are expected to provide a scientific rationale for the use of AOE in the treatment of PD. However, it is important that the active components that contribute to the neuroprotective action of AOE are identified and characterized. © Springer Science+Business Media, LLC 2011.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0272-4340en_US
dc.relation.ispartofCellular and Molecular Neurobiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animal - Drug Effectsen_US
dc.subject.meshCell Death - Drug Effectsen_US
dc.subject.meshCytoprotection - Drug Effectsen_US
dc.subject.meshDopaminergic Neurons - Drug Effects - Physiologyen_US
dc.subject.meshEmbryo, Nonmammalianen_US
dc.subject.meshEthanol - Pharmacologyen_US
dc.subject.meshLarva - Drug Effects - Growth & Development - Physiologyen_US
dc.subject.meshLocomotion - Drug Effectsen_US
dc.subject.meshOxidopamine - Toxicityen_US
dc.subject.meshPc12 Cellsen_US
dc.subject.meshPlant Extracts - Chemistry - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshZebrafish - Embryology - Growth & Developmenten_US
dc.titleEthanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafishen_US
dc.typeArticleen_US
dc.identifier.emailChu, IK:ivankchu@hku.hken_US
dc.identifier.authorityChu, IK=rp00683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10571-011-9731-0en_US
dc.identifier.pmid21744117en_US
dc.identifier.scopuseid_2-s2.0-84856534483en_US
dc.identifier.hkuros208681-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856534483&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue1en_US
dc.identifier.spage27en_US
dc.identifier.epage40en_US
dc.identifier.isiWOS:000299328600004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, ZJ=35742521800en_US
dc.identifier.scopusauthoridCheang, LCV=54947709800en_US
dc.identifier.scopusauthoridWang, MW=42263404500en_US
dc.identifier.scopusauthoridLi, GH=40462073700en_US
dc.identifier.scopusauthoridChu, IK=7103327484en_US
dc.identifier.scopusauthoridLin, ZX=26433004200en_US
dc.identifier.scopusauthoridLee, SMY=54947119900en_US
dc.identifier.citeulike9547239-

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