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Article: Ethanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish
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TitleEthanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish
 
AuthorsZhang, ZJ2 3
Cheang, LCV2
Wang, MW2
Li, GH1
Chu, IK1
Lin, ZX4
Lee, SMY2
 
Issue Date2012
 
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0272-4340
 
CitationCellular And Molecular Neurobiology, 2012, v. 32 n. 1, p. 27-40 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10571-011-9731-0
 
AbstractIn an attempt to understand the neuroprotective effect of Fructus Alpinia oxyphylla (AOE) and to elucidate its underlying mechanism of action, the ethanolic extract of AOE was investigated using zebrafish and PC12 cell models. AOE prevented and restored 6-hydroxydopamine (6-OHDA)-induced dopaminergic (DA) neuron degeneration and attenuated a deficit of locomotor activity in a zebrafish (Danio rerio) model of Parkinson's disease (PD). Treatment with AOE increased the viability of 6-OHDAtreated PC12 cells in vitro in a dose-dependent manner by attenuating cellular apoptosis. However, protocatechuic acid (PCA) and chrysin, two known polyphenol components of AOE, could not reproduce the neuroprotective activity of AOE in the PD zebrafish or PC12 cell models. A mechanistic study found that the protective effect of AOE against 6-OHDA-induced neuronal injury involved antiinflammatory action (down-regulation of gene expression of IL-1β and TNF-α) and anti-oxidative action (inhibition of NO production and iNOS expression in PC12 cells). Moreover, the PI3K-AKT pathway might be part of the mechanism of neuroprotection of AOE. The results of this research are expected to provide a scientific rationale for the use of AOE in the treatment of PD. However, it is important that the active components that contribute to the neuroprotective action of AOE are identified and characterized. © Springer Science+Business Media, LLC 2011.
 
ISSN0272-4340
2013 Impact Factor: 2.201
 
DOIhttp://dx.doi.org/10.1007/s10571-011-9731-0
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, ZJ
 
dc.contributor.authorCheang, LCV
 
dc.contributor.authorWang, MW
 
dc.contributor.authorLi, GH
 
dc.contributor.authorChu, IK
 
dc.contributor.authorLin, ZX
 
dc.contributor.authorLee, SMY
 
dc.date.accessioned2012-10-08T03:21:28Z
 
dc.date.available2012-10-08T03:21:28Z
 
dc.date.issued2012
 
dc.description.abstractIn an attempt to understand the neuroprotective effect of Fructus Alpinia oxyphylla (AOE) and to elucidate its underlying mechanism of action, the ethanolic extract of AOE was investigated using zebrafish and PC12 cell models. AOE prevented and restored 6-hydroxydopamine (6-OHDA)-induced dopaminergic (DA) neuron degeneration and attenuated a deficit of locomotor activity in a zebrafish (Danio rerio) model of Parkinson's disease (PD). Treatment with AOE increased the viability of 6-OHDAtreated PC12 cells in vitro in a dose-dependent manner by attenuating cellular apoptosis. However, protocatechuic acid (PCA) and chrysin, two known polyphenol components of AOE, could not reproduce the neuroprotective activity of AOE in the PD zebrafish or PC12 cell models. A mechanistic study found that the protective effect of AOE against 6-OHDA-induced neuronal injury involved antiinflammatory action (down-regulation of gene expression of IL-1β and TNF-α) and anti-oxidative action (inhibition of NO production and iNOS expression in PC12 cells). Moreover, the PI3K-AKT pathway might be part of the mechanism of neuroprotection of AOE. The results of this research are expected to provide a scientific rationale for the use of AOE in the treatment of PD. However, it is important that the active components that contribute to the neuroprotective action of AOE are identified and characterized. © Springer Science+Business Media, LLC 2011.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCellular And Molecular Neurobiology, 2012, v. 32 n. 1, p. 27-40 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10571-011-9731-0
 
dc.identifier.citeulike9547239
 
dc.identifier.doihttp://dx.doi.org/10.1007/s10571-011-9731-0
 
dc.identifier.epage40
 
dc.identifier.hkuros208681
 
dc.identifier.issn0272-4340
2013 Impact Factor: 2.201
 
dc.identifier.issue1
 
dc.identifier.pmid21744117
 
dc.identifier.scopuseid_2-s2.0-84856534483
 
dc.identifier.spage27
 
dc.identifier.urihttp://hdl.handle.net/10722/168606
 
dc.identifier.volume32
 
dc.languageeng
 
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0272-4340
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCellular and Molecular Neurobiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshBehavior, Animal - Drug Effects
 
dc.subject.meshCell Death - Drug Effects
 
dc.subject.meshCytoprotection - Drug Effects
 
dc.subject.meshDopaminergic Neurons - Drug Effects - Physiology
 
dc.subject.meshEmbryo, Nonmammalian
 
dc.subject.meshEthanol - Pharmacology
 
dc.subject.meshLarva - Drug Effects - Growth & Development - Physiology
 
dc.subject.meshLocomotion - Drug Effects
 
dc.subject.meshOxidopamine - Toxicity
 
dc.subject.meshPc12 Cells
 
dc.subject.meshPlant Extracts - Chemistry - Pharmacology
 
dc.subject.meshRats
 
dc.subject.meshZebrafish - Embryology - Growth & Development
 
dc.titleEthanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. University of Macau
  3. Jinan University
  4. Chinese University of Hong Kong