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Article: Heme oxygenase-1 system and gastrointestinal inflammation: A short review
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TitleHeme oxygenase-1 system and gastrointestinal inflammation: A short review
 
AuthorsZhu, X1 3
Fan, WG4
Li, DP4
Kung, H5
Lin, MCM2
 
Issue Date2011
 
PublisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
 
CitationWorld Journal Of Gastroenterology, 2011, v. 17 n. 38, p. 4283-4288 [How to Cite?]
DOI: http://dx.doi.org/10.3748/wjg.v17.i38.4283
 
AbstractHeme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved.
 
ISSN1007-9327
2013 Impact Factor: 2.433
2013 SCImago Journal Rankings: 1.022
 
DOIhttp://dx.doi.org/10.3748/wjg.v17.i38.4283
 
PubMed Central IDPMC3214703
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhu, X
 
dc.contributor.authorFan, WG
 
dc.contributor.authorLi, DP
 
dc.contributor.authorKung, H
 
dc.contributor.authorLin, MCM
 
dc.date.accessioned2012-10-08T03:21:06Z
 
dc.date.available2012-10-08T03:21:06Z
 
dc.date.issued2011
 
dc.description.abstractHeme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved.
 
dc.description.naturePublished_or_final_version
 
dc.identifier.citationWorld Journal Of Gastroenterology, 2011, v. 17 n. 38, p. 4283-4288 [How to Cite?]
DOI: http://dx.doi.org/10.3748/wjg.v17.i38.4283
 
dc.identifier.doihttp://dx.doi.org/10.3748/wjg.v17.i38.4283
 
dc.identifier.epage4288
 
dc.identifier.issn1007-9327
2013 Impact Factor: 2.433
2013 SCImago Journal Rankings: 1.022
 
dc.identifier.issue38
 
dc.identifier.pmcidPMC3214703
 
dc.identifier.pmid22090784
 
dc.identifier.scopuseid_2-s2.0-80955151281
 
dc.identifier.spage4283
 
dc.identifier.urihttp://hdl.handle.net/10722/168585
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
 
dc.publisher.placeChina
 
dc.relation.ispartofWorld Journal of Gastroenterology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAnimals
 
dc.subject.meshBilirubin - Metabolism
 
dc.subject.meshBiliverdine - Metabolism
 
dc.subject.meshGastrointestinal Tract - Enzymology - Pathology
 
dc.subject.meshHeme Oxygenase-1 - Genetics - Metabolism
 
dc.subject.meshHumans
 
dc.subject.meshInflammation - Enzymology - Pathology
 
dc.subject.meshIron - Metabolism
 
dc.subject.meshIsoenzymes - Genetics - Metabolism
 
dc.subject.meshNitric Oxide Synthase Type Ii - Metabolism
 
dc.subject.meshPolymorphism, Genetic
 
dc.subject.meshPromoter Regions, Genetic
 
dc.subject.meshUp-Regulation
 
dc.titleHeme oxygenase-1 system and gastrointestinal inflammation: A short review
 
dc.typeArticle
 
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<contributor.author>Lin, MCM</contributor.author>
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Author Affiliations
  1. Guangdong Medical College
  2. Prince of Wales Hospital Hong Kong
  3. Cancer Institute and Hospital, Chinese Academy of Medical Sciences
  4. Sun Yat-Sen University
  5. Chinese University of Hong Kong