Article: Heme oxygenase-1 system and gastrointestinal inflammation: A short review

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Publisher Website: 10.3748/wjg.v17.i38.4283
Scopus: eid_2-s2.0-80955151281
PMID: 22090784

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Title	Heme oxygenase-1 system and gastrointestinal inflammation: A short review
Authors	Zhu, X1 2 Fan, WG3 Li, DP3 Kung, H4 Lin, MCM4
Issue Date	2011
Publisher	Beijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation	World Journal Of Gastroenterology, 2011, v. 17 n. 38, p. 4283-4288 [How to Cite?] DOI: http://dx.doi.org/10.3748/wjg.v17.i38.4283
Abstract	Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved.
ISSN	1007-9327 2011 Impact Factor: 2.471 2011 SCImago Journal Rankings: 0.189
DOI	http://dx.doi.org/10.3748/wjg.v17.i38.4283
References	References in Scopus

DC Field	Value
dc.contributor.author	Zhu, X
dc.contributor.author	Fan, WG
dc.contributor.author	Li, DP
dc.contributor.author	Kung, H
dc.contributor.author	Lin, MCM
dc.date.accessioned	2012-10-08T03:21:06Z
dc.date.available	2012-10-08T03:21:06Z
dc.date.issued	2011
dc.description.abstract	Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	World Journal Of Gastroenterology, 2011, v. 17 n. 38, p. 4283-4288 [How to Cite?] DOI: http://dx.doi.org/10.3748/wjg.v17.i38.4283
dc.identifier.doi	http://dx.doi.org/10.3748/wjg.v17.i38.4283
dc.identifier.epage	4288
dc.identifier.issn	1007-9327 2011 Impact Factor: 2.471 2011 SCImago Journal Rankings: 0.189
dc.identifier.issue	38
dc.identifier.pmid	22090784
dc.identifier.scopus	eid_2-s2.0-80955151281
dc.identifier.spage	4283
dc.identifier.uri	http://hdl.handle.net/10722/168585
dc.identifier.volume	17
dc.language	eng
dc.publisher	Beijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
dc.publisher.place	China
dc.relation.ispartof	World Journal of Gastroenterology
dc.relation.references	References in Scopus
dc.subject.mesh	Animals
dc.subject.mesh	Bilirubin - Metabolism
dc.subject.mesh	Biliverdine - Metabolism
dc.subject.mesh	Gastrointestinal Tract - Enzymology - Pathology
dc.subject.mesh	Heme Oxygenase-1 - Genetics - Metabolism
dc.subject.mesh	Humans
dc.subject.mesh	Inflammation - Enzymology - Pathology
dc.subject.mesh	Iron - Metabolism
dc.subject.mesh	Isoenzymes - Genetics - Metabolism
dc.subject.mesh	Nitric Oxide Synthase Type Ii - Metabolism
dc.subject.mesh	Polymorphism, Genetic
dc.subject.mesh	Promoter Regions, Genetic
dc.subject.mesh	Up-Regulation
dc.title	Heme oxygenase-1 system and gastrointestinal inflammation: A short review
dc.type	Article

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Author Affiliations

Guangdong Medical College
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Sun Yat-Sen University
Chinese University of Hong Kong

Article: Heme oxygenase-1 system and gastrointestinal inflammation: A short review

The HKU Scholars Hub has contact details for these author(s).