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Article: Heme oxygenase-1 system and gastrointestinal inflammation: A short review

TitleHeme oxygenase-1 system and gastrointestinal inflammation: A short review
Authors
Issue Date2011
PublisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2011, v. 17 n. 38, p. 4283-4288 How to Cite?
Abstract
Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/168585
ISSN
2013 Impact Factor: 2.433
2013 SCImago Journal Rankings: 1.022
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, Xen_US
dc.contributor.authorFan, WGen_US
dc.contributor.authorLi, DPen_US
dc.contributor.authorKung, Hen_US
dc.contributor.authorLin, MCMen_US
dc.date.accessioned2012-10-08T03:21:06Z-
dc.date.available2012-10-08T03:21:06Z-
dc.date.issued2011en_US
dc.identifier.citationWorld Journal Of Gastroenterology, 2011, v. 17 n. 38, p. 4283-4288en_US
dc.identifier.issn1007-9327en_US
dc.identifier.urihttp://hdl.handle.net/10722/168585-
dc.description.abstractHeme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved.en_US
dc.languageengen_US
dc.publisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_US
dc.relation.ispartofWorld Journal of Gastroenterologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnimalsen_US
dc.subject.meshBilirubin - Metabolismen_US
dc.subject.meshBiliverdine - Metabolismen_US
dc.subject.meshGastrointestinal Tract - Enzymology - Pathologyen_US
dc.subject.meshHeme Oxygenase-1 - Genetics - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation - Enzymology - Pathologyen_US
dc.subject.meshIron - Metabolismen_US
dc.subject.meshIsoenzymes - Genetics - Metabolismen_US
dc.subject.meshNitric Oxide Synthase Type Ii - Metabolismen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshUp-Regulationen_US
dc.titleHeme oxygenase-1 system and gastrointestinal inflammation: A short reviewen_US
dc.typeArticleen_US
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MCM=rp00746en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.3748/wjg.v17.i38.4283en_US
dc.identifier.pmid22090784en_US
dc.identifier.pmcidPMC3214703-
dc.identifier.scopuseid_2-s2.0-80955151281en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80955151281&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue38en_US
dc.identifier.spage4283en_US
dc.identifier.epage4288en_US
dc.identifier.isiWOS:000297220600005-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridZhu, X=34869035800en_US
dc.identifier.scopusauthoridFan, WG=24070406000en_US
dc.identifier.scopusauthoridLi, DP=54412759300en_US
dc.identifier.scopusauthoridKung, H=7402514190en_US
dc.identifier.scopusauthoridLin, MCM=7404816359en_US

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