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Article: MicroRNAs: Potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma
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TitleMicroRNAs: Potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma
 
AuthorsHe, ML1
Luo, MXM1
Lin, MC1
Kung, HF1
 
Issue Date2012
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbaroco
 
CitationBiochimica Et Biophysica Acta - Reviews On Cancer, 2012, v. 1825 n. 1, p. 1-10 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.bbcan.2011.09.001
 
AbstractNasopharyngeal carcinoma (NPC) is a highly malignant cancer with local invasion and early distant metastasis. NPC is highly prevalent in the Southern China and South-eastern Asia. The genetic susceptibility, endemic environment factors, and Epstein-Barr virus (EBV) infection are believed to be the major etiologic factors of NPC. Once metastasis occurs, the prognosis is very poor. It is urgently needed to develop biomarkers for early clinical diagnosis/prognosis, and novel effective therapies for nasopharyngeal carcinoma. In this paper, we systematically reviewed the current progress of miRNA studies in NPC. It has been shown that both host encoded miRNAs and EBV encoded miRNAs play key roles in almost all the steps of epithelia cell carcinogenesis, including epithelial-mesenchymal to stem-like transition, cell growth, migration, invasion, and tumorigenesis. More importantly, some miRNAs could be secreted out and play a role in the microenvironments. The level of sera miRNAs is correlated with the copy numbers of host miRNAs in tumor biopsies. Promising results of gene therapy have been also achieved by lentiviral delivered miRNAs. Taken together, cell free miRNAs would be potential biomarkers of early clinical diagnosis/prognosis; while some miRNAs could be further developed into therapeutic agents in the future. © 2011 Elsevier B.V.
 
ISSN0304-419X
2013 Impact Factor: 7.584
2013 SCImago Journal Rankings: 3.823
 
DOIhttp://dx.doi.org/10.1016/j.bbcan.2011.09.001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHe, ML
 
dc.contributor.authorLuo, MXM
 
dc.contributor.authorLin, MC
 
dc.contributor.authorKung, HF
 
dc.date.accessioned2012-10-08T03:20:54Z
 
dc.date.available2012-10-08T03:20:54Z
 
dc.date.issued2012
 
dc.description.abstractNasopharyngeal carcinoma (NPC) is a highly malignant cancer with local invasion and early distant metastasis. NPC is highly prevalent in the Southern China and South-eastern Asia. The genetic susceptibility, endemic environment factors, and Epstein-Barr virus (EBV) infection are believed to be the major etiologic factors of NPC. Once metastasis occurs, the prognosis is very poor. It is urgently needed to develop biomarkers for early clinical diagnosis/prognosis, and novel effective therapies for nasopharyngeal carcinoma. In this paper, we systematically reviewed the current progress of miRNA studies in NPC. It has been shown that both host encoded miRNAs and EBV encoded miRNAs play key roles in almost all the steps of epithelia cell carcinogenesis, including epithelial-mesenchymal to stem-like transition, cell growth, migration, invasion, and tumorigenesis. More importantly, some miRNAs could be secreted out and play a role in the microenvironments. The level of sera miRNAs is correlated with the copy numbers of host miRNAs in tumor biopsies. Promising results of gene therapy have been also achieved by lentiviral delivered miRNAs. Taken together, cell free miRNAs would be potential biomarkers of early clinical diagnosis/prognosis; while some miRNAs could be further developed into therapeutic agents in the future. © 2011 Elsevier B.V.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBiochimica Et Biophysica Acta - Reviews On Cancer, 2012, v. 1825 n. 1, p. 1-10 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.bbcan.2011.09.001
 
dc.identifier.citeulike9857921
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbcan.2011.09.001
 
dc.identifier.epage10
 
dc.identifier.issn0304-419X
2013 Impact Factor: 7.584
2013 SCImago Journal Rankings: 3.823
 
dc.identifier.issue1
 
dc.identifier.pmid21958739
 
dc.identifier.scopuseid_2-s2.0-80053537922
 
dc.identifier.spage1
 
dc.identifier.urihttp://hdl.handle.net/10722/168571
 
dc.identifier.volume1825
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbaroco
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofBiochimica et Biophysica Acta - Reviews on Cancer
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshGene Therapy - Methods
 
dc.subject.meshHerpesvirus 4, Human - Genetics
 
dc.subject.meshHumans
 
dc.subject.meshMicrornas - Analysis
 
dc.subject.meshMolecular Targeted Therapy
 
dc.subject.meshNasopharyngeal Neoplasms - Diagnosis - Genetics - Therapy - Virology
 
dc.subject.meshPrognosis
 
dc.subject.meshRna, Viral - Analysis
 
dc.subject.meshTumor Markers, Biological - Analysis
 
dc.titleMicroRNAs: Potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma
 
dc.typeArticle
 
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Author Affiliations
  1. Chinese University of Hong Kong