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Article: MicroRNAs: Potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma

TitleMicroRNAs: Potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma
Authors
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbaroco
Citation
Biochimica Et Biophysica Acta - Reviews On Cancer, 2012, v. 1825 n. 1, p. 1-10 How to Cite?
Abstract
Nasopharyngeal carcinoma (NPC) is a highly malignant cancer with local invasion and early distant metastasis. NPC is highly prevalent in the Southern China and South-eastern Asia. The genetic susceptibility, endemic environment factors, and Epstein-Barr virus (EBV) infection are believed to be the major etiologic factors of NPC. Once metastasis occurs, the prognosis is very poor. It is urgently needed to develop biomarkers for early clinical diagnosis/prognosis, and novel effective therapies for nasopharyngeal carcinoma. In this paper, we systematically reviewed the current progress of miRNA studies in NPC. It has been shown that both host encoded miRNAs and EBV encoded miRNAs play key roles in almost all the steps of epithelia cell carcinogenesis, including epithelial-mesenchymal to stem-like transition, cell growth, migration, invasion, and tumorigenesis. More importantly, some miRNAs could be secreted out and play a role in the microenvironments. The level of sera miRNAs is correlated with the copy numbers of host miRNAs in tumor biopsies. Promising results of gene therapy have been also achieved by lentiviral delivered miRNAs. Taken together, cell free miRNAs would be potential biomarkers of early clinical diagnosis/prognosis; while some miRNAs could be further developed into therapeutic agents in the future. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/168571
ISSN
2013 Impact Factor: 7.584
2013 SCImago Journal Rankings: 3.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHe, MLen_US
dc.contributor.authorLuo, MXMen_US
dc.contributor.authorLin, MCen_US
dc.contributor.authorKung, HFen_US
dc.date.accessioned2012-10-08T03:20:54Z-
dc.date.available2012-10-08T03:20:54Z-
dc.date.issued2012en_US
dc.identifier.citationBiochimica Et Biophysica Acta - Reviews On Cancer, 2012, v. 1825 n. 1, p. 1-10en_US
dc.identifier.issn0304-419Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/168571-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a highly malignant cancer with local invasion and early distant metastasis. NPC is highly prevalent in the Southern China and South-eastern Asia. The genetic susceptibility, endemic environment factors, and Epstein-Barr virus (EBV) infection are believed to be the major etiologic factors of NPC. Once metastasis occurs, the prognosis is very poor. It is urgently needed to develop biomarkers for early clinical diagnosis/prognosis, and novel effective therapies for nasopharyngeal carcinoma. In this paper, we systematically reviewed the current progress of miRNA studies in NPC. It has been shown that both host encoded miRNAs and EBV encoded miRNAs play key roles in almost all the steps of epithelia cell carcinogenesis, including epithelial-mesenchymal to stem-like transition, cell growth, migration, invasion, and tumorigenesis. More importantly, some miRNAs could be secreted out and play a role in the microenvironments. The level of sera miRNAs is correlated with the copy numbers of host miRNAs in tumor biopsies. Promising results of gene therapy have been also achieved by lentiviral delivered miRNAs. Taken together, cell free miRNAs would be potential biomarkers of early clinical diagnosis/prognosis; while some miRNAs could be further developed into therapeutic agents in the future. © 2011 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbarocoen_US
dc.relation.ispartofBiochimica et Biophysica Acta - Reviews on Canceren_US
dc.subject.meshGene Therapy - Methodsen_US
dc.subject.meshHerpesvirus 4, Human - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMicrornas - Analysisen_US
dc.subject.meshMolecular Targeted Therapyen_US
dc.subject.meshNasopharyngeal Neoplasms - Diagnosis - Genetics - Therapy - Virologyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRna, Viral - Analysisen_US
dc.subject.meshTumor Markers, Biological - Analysisen_US
dc.titleMicroRNAs: Potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbcan.2011.09.001en_US
dc.identifier.pmid21958739en_US
dc.identifier.scopuseid_2-s2.0-80053537922en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053537922&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1825en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage10en_US
dc.identifier.isiWOS:000299986800001-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridHe, ML=35080389700en_US
dc.identifier.scopusauthoridLuo, MXM=54783022000en_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US
dc.identifier.scopusauthoridKung, HF=7402514190en_US
dc.identifier.citeulike9857921-

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