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Article: An intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers
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TitleAn intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers
 
AuthorsZhu, X1 3
Chen, L4
Fan, W4
Lin, MCM2
Tian, L5
Wang, M3
Lin, S2
Wang, Z2
Zhang, J5
Wang, J3
Yao, H2 5
Kung, H5
Li, D4
 
Issue Date2011
 
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
CitationPlos One, 2011, v. 6 n. 7 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0021997
 
AbstractBackground: Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis. Methodology/Principal Findings: 539 non-HBV-infected individuals, 205 self-limited infection and 496 persistent HBV infection were recruited between January 2001 and April 2005 from the hospitals in Southern China. Genomic DNA was genotyped for rs430397. The associations between the variation and susceptibility to liver cirrhosis (LC) in persistent HBV infection were examined. We observed that individuals carrying allele rs430397A were more likely to become HBV-related LC. When persistently infected patients were divided into four subgroups, patients with phase IV had an increased allele A and genotype AG compared with phase I and/or phase III. Decreased serum albumin and prolonged plasma prothrombin time (PT) were showed in LC patients carrying genotype AA. Furthermore, rs430397 genotype had an increased susceptibility to LC with dose-dependent manners (P-trend = 0.005), and the genotype did constitute a risk factor for the development of advanced LC (Child-Pugh classification C and B, P-trend = 0.021). Conclusions/Significance: rs430397 polymorphism may be a contributing factor to LC in persistent HBV carriers. © 2011 Zhu et al.
 
ISSN1932-6203
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
 
DOIhttp://dx.doi.org/10.1371/journal.pone.0021997
 
ISI Accession Number IDWOS:000292811300033
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhu, X
 
dc.contributor.authorChen, L
 
dc.contributor.authorFan, W
 
dc.contributor.authorLin, MCM
 
dc.contributor.authorTian, L
 
dc.contributor.authorWang, M
 
dc.contributor.authorLin, S
 
dc.contributor.authorWang, Z
 
dc.contributor.authorZhang, J
 
dc.contributor.authorWang, J
 
dc.contributor.authorYao, H
 
dc.contributor.authorKung, H
 
dc.contributor.authorLi, D
 
dc.date.accessioned2012-10-08T03:20:20Z
 
dc.date.available2012-10-08T03:20:20Z
 
dc.date.issued2011
 
dc.description.abstractBackground: Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis. Methodology/Principal Findings: 539 non-HBV-infected individuals, 205 self-limited infection and 496 persistent HBV infection were recruited between January 2001 and April 2005 from the hospitals in Southern China. Genomic DNA was genotyped for rs430397. The associations between the variation and susceptibility to liver cirrhosis (LC) in persistent HBV infection were examined. We observed that individuals carrying allele rs430397A were more likely to become HBV-related LC. When persistently infected patients were divided into four subgroups, patients with phase IV had an increased allele A and genotype AG compared with phase I and/or phase III. Decreased serum albumin and prolonged plasma prothrombin time (PT) were showed in LC patients carrying genotype AA. Furthermore, rs430397 genotype had an increased susceptibility to LC with dose-dependent manners (P-trend = 0.005), and the genotype did constitute a risk factor for the development of advanced LC (Child-Pugh classification C and B, P-trend = 0.021). Conclusions/Significance: rs430397 polymorphism may be a contributing factor to LC in persistent HBV carriers. © 2011 Zhu et al.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPlos One, 2011, v. 6 n. 7 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0021997
 
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0021997
 
dc.identifier.isiWOS:000292811300033
 
dc.identifier.issn1932-6203
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
 
dc.identifier.issue7
 
dc.identifier.pmid21779363
 
dc.identifier.scopuseid_2-s2.0-79960292957
 
dc.identifier.urihttp://hdl.handle.net/10722/168540
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPLoS ONE
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.titleAn intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers
 
dc.typeArticle
 
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<contributor.author>Chen, L</contributor.author>
<contributor.author>Fan, W</contributor.author>
<contributor.author>Lin, MCM</contributor.author>
<contributor.author>Tian, L</contributor.author>
<contributor.author>Wang, M</contributor.author>
<contributor.author>Lin, S</contributor.author>
<contributor.author>Wang, Z</contributor.author>
<contributor.author>Zhang, J</contributor.author>
<contributor.author>Wang, J</contributor.author>
<contributor.author>Yao, H</contributor.author>
<contributor.author>Kung, H</contributor.author>
<contributor.author>Li, D</contributor.author>
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<description.abstract>Background: Our previous study indicated that a common variant (rs430397 G&gt;A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis. Methodology/Principal Findings: 539 non-HBV-infected individuals, 205 self-limited infection and 496 persistent HBV infection were recruited between January 2001 and April 2005 from the hospitals in Southern China. Genomic DNA was genotyped for rs430397. The associations between the variation and susceptibility to liver cirrhosis (LC) in persistent HBV infection were examined. We observed that individuals carrying allele rs430397A were more likely to become HBV-related LC. When persistently infected patients were divided into four subgroups, patients with phase IV had an increased allele A and genotype AG compared with phase I and/or phase III. Decreased serum albumin and prolonged plasma prothrombin time (PT) were showed in LC patients carrying genotype AA. Furthermore, rs430397 genotype had an increased susceptibility to LC with dose-dependent manners (P-trend = 0.005), and the genotype did constitute a risk factor for the development of advanced LC (Child-Pugh classification C and B, P-trend = 0.021). Conclusions/Significance: rs430397 polymorphism may be a contributing factor to LC in persistent HBV carriers. &#169; 2011 Zhu et al.</description.abstract>
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Author Affiliations
  1. Guangdong Medical College
  2. Prince of Wales Hospital Hong Kong
  3. Cancer Institute and Hospital, Chinese Academy of Medical Sciences
  4. Sun Yat-Sen University
  5. Chinese University of Hong Kong