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Article: An intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers

TitleAn intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 7 How to Cite?
Abstract
Background: Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis. Methodology/Principal Findings: 539 non-HBV-infected individuals, 205 self-limited infection and 496 persistent HBV infection were recruited between January 2001 and April 2005 from the hospitals in Southern China. Genomic DNA was genotyped for rs430397. The associations between the variation and susceptibility to liver cirrhosis (LC) in persistent HBV infection were examined. We observed that individuals carrying allele rs430397A were more likely to become HBV-related LC. When persistently infected patients were divided into four subgroups, patients with phase IV had an increased allele A and genotype AG compared with phase I and/or phase III. Decreased serum albumin and prolonged plasma prothrombin time (PT) were showed in LC patients carrying genotype AA. Furthermore, rs430397 genotype had an increased susceptibility to LC with dose-dependent manners (P-trend = 0.005), and the genotype did constitute a risk factor for the development of advanced LC (Child-Pugh classification C and B, P-trend = 0.021). Conclusions/Significance: rs430397 polymorphism may be a contributing factor to LC in persistent HBV carriers. © 2011 Zhu et al.
Persistent Identifierhttp://hdl.handle.net/10722/168540
ISSN
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
ISI Accession Number ID
References

 

Author Affiliations
  1. Guangdong Medical College
  2. Prince of Wales Hospital Hong Kong
  3. Cancer Institute and Hospital, Chinese Academy of Medical Sciences
  4. Sun Yat-Sen University
  5. Chinese University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorZhu, Xen_US
dc.contributor.authorChen, Len_US
dc.contributor.authorFan, Wen_US
dc.contributor.authorLin, MCMen_US
dc.contributor.authorTian, Len_US
dc.contributor.authorWang, Men_US
dc.contributor.authorLin, Sen_US
dc.contributor.authorWang, Zen_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorYao, Hen_US
dc.contributor.authorKung, Hen_US
dc.contributor.authorLi, Den_US
dc.date.accessioned2012-10-08T03:20:20Z-
dc.date.available2012-10-08T03:20:20Z-
dc.date.issued2011en_US
dc.identifier.citationPlos One, 2011, v. 6 n. 7en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/168540-
dc.description.abstractBackground: Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis. Methodology/Principal Findings: 539 non-HBV-infected individuals, 205 self-limited infection and 496 persistent HBV infection were recruited between January 2001 and April 2005 from the hospitals in Southern China. Genomic DNA was genotyped for rs430397. The associations between the variation and susceptibility to liver cirrhosis (LC) in persistent HBV infection were examined. We observed that individuals carrying allele rs430397A were more likely to become HBV-related LC. When persistently infected patients were divided into four subgroups, patients with phase IV had an increased allele A and genotype AG compared with phase I and/or phase III. Decreased serum albumin and prolonged plasma prothrombin time (PT) were showed in LC patients carrying genotype AA. Furthermore, rs430397 genotype had an increased susceptibility to LC with dose-dependent manners (P-trend = 0.005), and the genotype did constitute a risk factor for the development of advanced LC (Child-Pugh classification C and B, P-trend = 0.021). Conclusions/Significance: rs430397 polymorphism may be a contributing factor to LC in persistent HBV carriers. © 2011 Zhu et al.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAn intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriersen_US
dc.typeArticleen_US
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MCM=rp00746en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0021997en_US
dc.identifier.pmid21779363-
dc.identifier.scopuseid_2-s2.0-79960292957en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960292957&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue7en_US
dc.identifier.isiWOS:000292811300033-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhu, X=23491117800en_US
dc.identifier.scopusauthoridChen, L=37112067500en_US
dc.identifier.scopusauthoridFan, W=24070406000en_US
dc.identifier.scopusauthoridLin, MCM=7404816359en_US
dc.identifier.scopusauthoridTian, L=7202296490en_US
dc.identifier.scopusauthoridWang, M=46261729500en_US
dc.identifier.scopusauthoridLin, S=46261455900en_US
dc.identifier.scopusauthoridWang, Z=46261621900en_US
dc.identifier.scopusauthoridZhang, J=46261770200en_US
dc.identifier.scopusauthoridWang, J=46261635300en_US
dc.identifier.scopusauthoridYao, H=13104506400en_US
dc.identifier.scopusauthoridKung, H=7402514190en_US
dc.identifier.scopusauthoridLi, D=24463373900en_US

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