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Article: Group 9 metal-based inhibitors of β-amyloid (1-40) fibrillation as potential therapeutic agents for Alzheimer's disease

TitleGroup 9 metal-based inhibitors of β-amyloid (1-40) fibrillation as potential therapeutic agents for Alzheimer's disease
Authors
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
Citation
Chemical Science, 2011, v. 2 n. 5, p. 917-921 How to Cite?
AbstractWe report here the first application of Group 9 metal complexes (i.e. iridium(III) and rhodium(III)) as inhibitors of amyloid fibrillogenesis and as luminescent probes for Aβ 1-40 peptide. These complexes contained aromatic co-ligands to interact with the hydrophobic residues around the N-terminal domain of the Aβ 1-40 peptide, as well as solvato co-ligands to allow coordinative bond formation with histidine residues. We demonstrate that these complexes could inhibit Aβ 1-40 peptide aggregation in vitro, with potency superior to previous metal-based inhibitors reported. Furthermore, we have demonstrated the first example of luminescent detection of Aβ 1-40 peptides by transition metal complexes. © The Royal Society of Chemistry 2011.
Persistent Identifierhttp://hdl.handle.net/10722/168525
ISSN
2015 Impact Factor: 9.144
2015 SCImago Journal Rankings: 4.974
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMan, BYWen_US
dc.contributor.authorChan, HMen_US
dc.contributor.authorLeung, CHen_US
dc.contributor.authorChan, DSHen_US
dc.contributor.authorBai, LPen_US
dc.contributor.authorJiang, ZHen_US
dc.contributor.authorLi, HWen_US
dc.contributor.authorMa, DLen_US
dc.date.accessioned2012-10-08T03:20:02Z-
dc.date.available2012-10-08T03:20:02Z-
dc.date.issued2011en_US
dc.identifier.citationChemical Science, 2011, v. 2 n. 5, p. 917-921en_US
dc.identifier.issn2041-6520en_US
dc.identifier.urihttp://hdl.handle.net/10722/168525-
dc.description.abstractWe report here the first application of Group 9 metal complexes (i.e. iridium(III) and rhodium(III)) as inhibitors of amyloid fibrillogenesis and as luminescent probes for Aβ 1-40 peptide. These complexes contained aromatic co-ligands to interact with the hydrophobic residues around the N-terminal domain of the Aβ 1-40 peptide, as well as solvato co-ligands to allow coordinative bond formation with histidine residues. We demonstrate that these complexes could inhibit Aβ 1-40 peptide aggregation in vitro, with potency superior to previous metal-based inhibitors reported. Furthermore, we have demonstrated the first example of luminescent detection of Aβ 1-40 peptides by transition metal complexes. © The Royal Society of Chemistry 2011.en_US
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.aspen_US
dc.relation.ispartofChemical Scienceen_US
dc.titleGroup 9 metal-based inhibitors of β-amyloid (1-40) fibrillation as potential therapeutic agents for Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_US
dc.identifier.emailMa, DL:edmondma@hku.hken_US
dc.identifier.authorityLeung, CH=rp00730en_US
dc.identifier.authorityMa, DL=rp00760en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1039/c0sc00636jen_US
dc.identifier.scopuseid_2-s2.0-79955607317en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955607317&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_US
dc.identifier.issue5en_US
dc.identifier.spage917en_US
dc.identifier.epage921en_US
dc.identifier.isiWOS:000290629600011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMan, BYW=36652999800en_US
dc.identifier.scopusauthoridChan, HM=37025584000en_US
dc.identifier.scopusauthoridLeung, CH=7402612570en_US
dc.identifier.scopusauthoridChan, DSH=35285471900en_US
dc.identifier.scopusauthoridBai, LP=35995180600en_US
dc.identifier.scopusauthoridJiang, ZH=7404279415en_US
dc.identifier.scopusauthoridLi, HW=35388768600en_US
dc.identifier.scopusauthoridMa, DL=7402075538en_US

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