Article: No association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinoma
| Title | No association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinoma |
|---|---|
| Authors | Zhu, X2 4 5 Wang, J4 Wang, Q3 Zhang, Y3 Chen, L3 Tian, L5 Shen, H4 Lin, MCM1 2 Wang, M4 Xie, D3 Kung, H5 |
| Issue Date | 2010 |
| Publisher | Hepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html |
| Citation | Hepato-Gastroenterology, 2010, v. 57 n. 102-103, p. 1191-1195 [How to Cite?] |
| Abstract | Background/Aims: Glucose-regulated protein 78 (GRP78), being a major chaperone, is implicated in the progression of hepatocellular carcinoma (HCC), and elevated GRP78 levels in tissues had been known to be related with poor prognosis in patients with HCC. In the present study, we investigated the possible association between the polymorphisms of haplotypic block in the 3′ untranslated region (UTR) of GRP78 and HCC risk in a Han Chinese population. Methodology: DNA from 576 unrelated patients with HCC and 539 sex- and age-matched healthy controls was typed for rsl6927997, rsll40763 and rsl2009 in the GRP78 gene by TaqMan assays. Polymorphism distributions were computed by logistic regression to test the association of certain alleles, genotypes, haplotypes and diplotypes with HCC risk. Results: Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distributions of allelotype, genotype, haplotype and diplotype in HCC patients were not significantly different from that in controls. Conclusion: The present study suggested that polymorphisms in the 3' UTR of GRP78 were not useful diagnostic markers to predict the HCC risk. © H.G.E. Update Medical Publishing S.A. |
| ISSN | 0172-6390 2011 Impact Factor: 0.658 2011 SCImago Journal Rankings: 0.077 |
| References | References in Scopus |
| dc.contributor.author | Zhu, X |
|---|---|
| dc.contributor.author | Wang, J |
| dc.contributor.author | Wang, Q |
| dc.contributor.author | Zhang, Y |
| dc.contributor.author | Chen, L |
| dc.contributor.author | Tian, L |
| dc.contributor.author | Shen, H |
| dc.contributor.author | Lin, MCM |
| dc.contributor.author | Wang, M |
| dc.contributor.author | Xie, D |
| dc.contributor.author | Kung, H |
| dc.date.accessioned | 2012-10-08T03:19:46Z |
| dc.date.available | 2012-10-08T03:19:46Z |
| dc.date.issued | 2010 |
| dc.description.abstract | Background/Aims: Glucose-regulated protein 78 (GRP78), being a major chaperone, is implicated in the progression of hepatocellular carcinoma (HCC), and elevated GRP78 levels in tissues had been known to be related with poor prognosis in patients with HCC. In the present study, we investigated the possible association between the polymorphisms of haplotypic block in the 3′ untranslated region (UTR) of GRP78 and HCC risk in a Han Chinese population. Methodology: DNA from 576 unrelated patients with HCC and 539 sex- and age-matched healthy controls was typed for rsl6927997, rsll40763 and rsl2009 in the GRP78 gene by TaqMan assays. Polymorphism distributions were computed by logistic regression to test the association of certain alleles, genotypes, haplotypes and diplotypes with HCC risk. Results: Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distributions of allelotype, genotype, haplotype and diplotype in HCC patients were not significantly different from that in controls. Conclusion: The present study suggested that polymorphisms in the 3' UTR of GRP78 were not useful diagnostic markers to predict the HCC risk. © H.G.E. Update Medical Publishing S.A. |
| dc.description.nature | Link_to_subscribed_fulltext |
| dc.identifier.citation | Hepato-Gastroenterology, 2010, v. 57 n. 102-103, p. 1191-1195 [How to Cite?] |
| dc.identifier.epage | 1195 |
| dc.identifier.issn | 0172-6390 2011 Impact Factor: 0.658 2011 SCImago Journal Rankings: 0.077 |
| dc.identifier.issue | 102-103 |
| dc.identifier.pmid | 21410057 |
| dc.identifier.scopus | eid_2-s2.0-79251574160 |
| dc.identifier.spage | 1191 |
| dc.identifier.uri | http://hdl.handle.net/10722/168505 |
| dc.identifier.volume | 57 |
| dc.language | eng |
| dc.publisher | Hepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html |
| dc.publisher.place | Greece |
| dc.relation.ispartof | Hepato-Gastroenterology |
| dc.relation.references | References in Scopus |
| dc.subject.mesh | 3' Untranslated Regions |
| dc.subject.mesh | Adult |
| dc.subject.mesh | Carcinoma, Hepatocellular - Etiology - Genetics |
| dc.subject.mesh | Female |
| dc.subject.mesh | Genetic Predisposition To Disease |
| dc.subject.mesh | Haplotypes |
| dc.subject.mesh | Heat-Shock Proteins - Genetics |
| dc.subject.mesh | Humans |
| dc.subject.mesh | Linkage Disequilibrium |
| dc.subject.mesh | Liver Neoplasms - Etiology - Genetics |
| dc.subject.mesh | Male |
| dc.subject.mesh | Middle Aged |
| dc.subject.mesh | Polymorphism, Single Nucleotide |
| dc.title | No association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinoma |
| dc.type | Article |
Author Affiliations
- Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
- Prince of Wales Hospital Hong Kong
- Sun Yat-Sen University
- Guangzhou Medical College
- Chinese University of Hong Kong