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Article: No association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinoma

TitleNo association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinoma
Authors
Issue Date2010
PublisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html
Citation
Hepato-Gastroenterology, 2010, v. 57 n. 102-103, p. 1191-1195 How to Cite?
Abstract
Background/Aims: Glucose-regulated protein 78 (GRP78), being a major chaperone, is implicated in the progression of hepatocellular carcinoma (HCC), and elevated GRP78 levels in tissues had been known to be related with poor prognosis in patients with HCC. In the present study, we investigated the possible association between the polymorphisms of haplotypic block in the 3′ untranslated region (UTR) of GRP78 and HCC risk in a Han Chinese population. Methodology: DNA from 576 unrelated patients with HCC and 539 sex- and age-matched healthy controls was typed for rsl6927997, rsll40763 and rsl2009 in the GRP78 gene by TaqMan assays. Polymorphism distributions were computed by logistic regression to test the association of certain alleles, genotypes, haplotypes and diplotypes with HCC risk. Results: Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distributions of allelotype, genotype, haplotype and diplotype in HCC patients were not significantly different from that in controls. Conclusion: The present study suggested that polymorphisms in the 3' UTR of GRP78 were not useful diagnostic markers to predict the HCC risk. © H.G.E. Update Medical Publishing S.A.
Persistent Identifierhttp://hdl.handle.net/10722/168505
ISSN
2013 Impact Factor: 0.907
2013 SCImago Journal Rankings: 0.431
ISI Accession Number ID
References

 

Author Affiliations
  1. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
  2. Prince of Wales Hospital Hong Kong
  3. Sun Yat-Sen University
  4. Guangzhou Medical College
  5. Chinese University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorZhu, Xen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorChen, Len_US
dc.contributor.authorTian, Len_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorLin, MCMen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorXie, Den_US
dc.contributor.authorKung, Hen_US
dc.date.accessioned2012-10-08T03:19:46Z-
dc.date.available2012-10-08T03:19:46Z-
dc.date.issued2010en_US
dc.identifier.citationHepato-Gastroenterology, 2010, v. 57 n. 102-103, p. 1191-1195en_US
dc.identifier.issn0172-6390en_US
dc.identifier.urihttp://hdl.handle.net/10722/168505-
dc.description.abstractBackground/Aims: Glucose-regulated protein 78 (GRP78), being a major chaperone, is implicated in the progression of hepatocellular carcinoma (HCC), and elevated GRP78 levels in tissues had been known to be related with poor prognosis in patients with HCC. In the present study, we investigated the possible association between the polymorphisms of haplotypic block in the 3′ untranslated region (UTR) of GRP78 and HCC risk in a Han Chinese population. Methodology: DNA from 576 unrelated patients with HCC and 539 sex- and age-matched healthy controls was typed for rsl6927997, rsll40763 and rsl2009 in the GRP78 gene by TaqMan assays. Polymorphism distributions were computed by logistic regression to test the association of certain alleles, genotypes, haplotypes and diplotypes with HCC risk. Results: Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distributions of allelotype, genotype, haplotype and diplotype in HCC patients were not significantly different from that in controls. Conclusion: The present study suggested that polymorphisms in the 3' UTR of GRP78 were not useful diagnostic markers to predict the HCC risk. © H.G.E. Update Medical Publishing S.A.en_US
dc.languageengen_US
dc.publisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.htmlen_US
dc.relation.ispartofHepato-Gastroenterologyen_US
dc.subject.mesh3' Untranslated Regionsen_US
dc.subject.meshAdulten_US
dc.subject.meshCarcinoma, Hepatocellular - Etiology - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHeat-Shock Proteins - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshLiver Neoplasms - Etiology - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.titleNo association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MCM=rp00746en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid21410057en_US
dc.identifier.scopuseid_2-s2.0-79251574160en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79251574160&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume57en_US
dc.identifier.issue102-103en_US
dc.identifier.spage1191en_US
dc.identifier.epage1195en_US
dc.identifier.isiWOS:000286564100037-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridZhu, X=23491117800en_US
dc.identifier.scopusauthoridWang, J=37113358200en_US
dc.identifier.scopusauthoridWang, Q=37113225200en_US
dc.identifier.scopusauthoridZhang, Y=36019742000en_US
dc.identifier.scopusauthoridChen, L=37112067500en_US
dc.identifier.scopusauthoridTian, L=7202296490en_US
dc.identifier.scopusauthoridShen, H=37113152500en_US
dc.identifier.scopusauthoridLin, MCM=7404816359en_US
dc.identifier.scopusauthoridWang, M=37113204600en_US
dc.identifier.scopusauthoridXie, D=35070710200en_US
dc.identifier.scopusauthoridKung, H=7402514190en_US

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