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Article: No association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinoma
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TitleNo association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinoma
 
AuthorsZhu, X4 2 5
Wang, J4
Wang, Q3
Zhang, Y3
Chen, L3
Tian, L5
Shen, H4
Lin, MCM2 1
Wang, M4
Xie, D3
Kung, H5
 
Issue Date2010
 
PublisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html
 
CitationHepato-Gastroenterology, 2010, v. 57 n. 102-103, p. 1191-1195 [How to Cite?]
 
AbstractBackground/Aims: Glucose-regulated protein 78 (GRP78), being a major chaperone, is implicated in the progression of hepatocellular carcinoma (HCC), and elevated GRP78 levels in tissues had been known to be related with poor prognosis in patients with HCC. In the present study, we investigated the possible association between the polymorphisms of haplotypic block in the 3′ untranslated region (UTR) of GRP78 and HCC risk in a Han Chinese population. Methodology: DNA from 576 unrelated patients with HCC and 539 sex- and age-matched healthy controls was typed for rsl6927997, rsll40763 and rsl2009 in the GRP78 gene by TaqMan assays. Polymorphism distributions were computed by logistic regression to test the association of certain alleles, genotypes, haplotypes and diplotypes with HCC risk. Results: Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distributions of allelotype, genotype, haplotype and diplotype in HCC patients were not significantly different from that in controls. Conclusion: The present study suggested that polymorphisms in the 3' UTR of GRP78 were not useful diagnostic markers to predict the HCC risk. © H.G.E. Update Medical Publishing S.A.
 
ISSN0172-6390
2012 Impact Factor: 0.774
2012 SCImago Journal Rankings: 0.363
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhu, X
 
dc.contributor.authorWang, J
 
dc.contributor.authorWang, Q
 
dc.contributor.authorZhang, Y
 
dc.contributor.authorChen, L
 
dc.contributor.authorTian, L
 
dc.contributor.authorShen, H
 
dc.contributor.authorLin, MCM
 
dc.contributor.authorWang, M
 
dc.contributor.authorXie, D
 
dc.contributor.authorKung, H
 
dc.date.accessioned2012-10-08T03:19:46Z
 
dc.date.available2012-10-08T03:19:46Z
 
dc.date.issued2010
 
dc.description.abstractBackground/Aims: Glucose-regulated protein 78 (GRP78), being a major chaperone, is implicated in the progression of hepatocellular carcinoma (HCC), and elevated GRP78 levels in tissues had been known to be related with poor prognosis in patients with HCC. In the present study, we investigated the possible association between the polymorphisms of haplotypic block in the 3′ untranslated region (UTR) of GRP78 and HCC risk in a Han Chinese population. Methodology: DNA from 576 unrelated patients with HCC and 539 sex- and age-matched healthy controls was typed for rsl6927997, rsll40763 and rsl2009 in the GRP78 gene by TaqMan assays. Polymorphism distributions were computed by logistic regression to test the association of certain alleles, genotypes, haplotypes and diplotypes with HCC risk. Results: Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distributions of allelotype, genotype, haplotype and diplotype in HCC patients were not significantly different from that in controls. Conclusion: The present study suggested that polymorphisms in the 3' UTR of GRP78 were not useful diagnostic markers to predict the HCC risk. © H.G.E. Update Medical Publishing S.A.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHepato-Gastroenterology, 2010, v. 57 n. 102-103, p. 1191-1195 [How to Cite?]
 
dc.identifier.epage1195
 
dc.identifier.issn0172-6390
2012 Impact Factor: 0.774
2012 SCImago Journal Rankings: 0.363
 
dc.identifier.issue102-103
 
dc.identifier.pmid21410057
 
dc.identifier.scopuseid_2-s2.0-79251574160
 
dc.identifier.spage1191
 
dc.identifier.urihttp://hdl.handle.net/10722/168505
 
dc.identifier.volume57
 
dc.languageeng
 
dc.publisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html
 
dc.publisher.placeGreece
 
dc.relation.ispartofHepato-Gastroenterology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.mesh3' Untranslated Regions
 
dc.subject.meshAdult
 
dc.subject.meshCarcinoma, Hepatocellular - Etiology - Genetics
 
dc.subject.meshFemale
 
dc.subject.meshGenetic Predisposition To Disease
 
dc.subject.meshHaplotypes
 
dc.subject.meshHeat-Shock Proteins - Genetics
 
dc.subject.meshHumans
 
dc.subject.meshLinkage Disequilibrium
 
dc.subject.meshLiver Neoplasms - Etiology - Genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.titleNo association between the haplotypic block in the 3′ UTR of GRP78 and risk of hepatocellular carcinoma
 
dc.typeArticle
 
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<contributor.author>Wang, J</contributor.author>
<contributor.author>Wang, Q</contributor.author>
<contributor.author>Zhang, Y</contributor.author>
<contributor.author>Chen, L</contributor.author>
<contributor.author>Tian, L</contributor.author>
<contributor.author>Shen, H</contributor.author>
<contributor.author>Lin, MCM</contributor.author>
<contributor.author>Wang, M</contributor.author>
<contributor.author>Xie, D</contributor.author>
<contributor.author>Kung, H</contributor.author>
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<date.available>2012-10-08T03:19:46Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>Hepato-Gastroenterology, 2010, v. 57 n. 102-103, p. 1191-1195</identifier.citation>
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<description.abstract>Background/Aims: Glucose-regulated protein 78 (GRP78), being a major chaperone, is implicated in the progression of hepatocellular carcinoma (HCC), and elevated GRP78 levels in tissues had been known to be related with poor prognosis in patients with HCC. In the present study, we investigated the possible association between the polymorphisms of haplotypic block in the 3&#8242; untranslated region (UTR) of GRP78 and HCC risk in a Han Chinese population. Methodology: DNA from 576 unrelated patients with HCC and 539 sex- and age-matched healthy controls was typed for rsl6927997, rsll40763 and rsl2009 in the GRP78 gene by TaqMan assays. Polymorphism distributions were computed by logistic regression to test the association of certain alleles, genotypes, haplotypes and diplotypes with HCC risk. Results: Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distributions of allelotype, genotype, haplotype and diplotype in HCC patients were not significantly different from that in controls. Conclusion: The present study suggested that polymorphisms in the 3&apos; UTR of GRP78 were not useful diagnostic markers to predict the HCC risk. &#169; H.G.E. Update Medical Publishing S.A.</description.abstract>
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Author Affiliations
  1. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
  2. Prince of Wales Hospital Hong Kong
  3. Sun Yat-Sen University
  4. Guangzhou Medical College
  5. Chinese University of Hong Kong