Article: Heme oxygenase-1 system and gastrointestinal tumors

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TitleHeme oxygenase-1 system and gastrointestinal tumors
AuthorsZhu, X3
Fan, WG2
Li, DP2
Lin, MCM1
Kung, H4
Issue Date2010
PublisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
CitationWorld Journal Of Gastroenterology, 2010, v. 16 n. 21, p. 2633-2637 [How to Cite?]
DOI: http://dx.doi.org/10.3748/wjg.v16.i21.2633
AbstractHeme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in many physiological and pathophysiological processes. A great deal of data has demonstrated the roles of HO-1 in the formation, growth and metastasis of tumors. The interest in this system by investigators involved in gastrointestinal tumors is fairly recent, and few papers on HO-1 have touched upon this subject. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to date. The implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed. © 2010 Baishideng. All rights reserved.
ISSN1007-9327
2011 Impact Factor: 2.471
2011 SCImago Journal Rankings: 0.189
DOIhttp://dx.doi.org/10.3748/wjg.v16.i21.2633
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhu, X
dc.contributor.authorFan, WG
dc.contributor.authorLi, DP
dc.contributor.authorLin, MCM
dc.contributor.authorKung, H
dc.date.accessioned2012-10-08T03:19:15Z
dc.date.available2012-10-08T03:19:15Z
dc.date.issued2010
dc.description.abstractHeme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in many physiological and pathophysiological processes. A great deal of data has demonstrated the roles of HO-1 in the formation, growth and metastasis of tumors. The interest in this system by investigators involved in gastrointestinal tumors is fairly recent, and few papers on HO-1 have touched upon this subject. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to date. The implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed. © 2010 Baishideng. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationWorld Journal Of Gastroenterology, 2010, v. 16 n. 21, p. 2633-2637 [How to Cite?]
DOI: http://dx.doi.org/10.3748/wjg.v16.i21.2633
dc.identifier.doihttp://dx.doi.org/10.3748/wjg.v16.i21.2633
dc.identifier.epage2637
dc.identifier.issn1007-9327
2011 Impact Factor: 2.471
2011 SCImago Journal Rankings: 0.189
dc.identifier.issue21
dc.identifier.pmid20518085
dc.identifier.scopuseid_2-s2.0-77953512037
dc.identifier.spage2633
dc.identifier.urihttp://hdl.handle.net/10722/168463
dc.identifier.volume16
dc.languageeng
dc.publisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
dc.publisher.placeChina
dc.relation.ispartofWorld Journal of Gastroenterology
dc.relation.referencesReferences in Scopus
dc.subject.meshEnzyme Induction
dc.subject.meshGastrointestinal Neoplasms - Enzymology - Pathology
dc.subject.meshHeme - Metabolism
dc.subject.meshHeme Oxygenase-1 - Genetics - Metabolism
dc.subject.meshHumans
dc.subject.meshIsoenzymes - Genetics - Metabolism
dc.subject.meshPolymorphism, Genetic
dc.subject.meshPromoter Regions, Genetic
dc.titleHeme oxygenase-1 system and gastrointestinal tumors
dc.typeArticle
Author Affiliations
  1. Prince of Wales Hospital Hong Kong
  2. Sun Yat-Sen University
  3. Guangzhou Medical College
  4. Chinese University of Hong Kong