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Article: Metal complexes in medicine with a focus on enzyme inhibition

TitleMetal complexes in medicine with a focus on enzyme inhibition
Authors
Issue Date2010
PublisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/cbi
Citation
Current Opinion In Chemical Biology, 2010, v. 14 n. 2, p. 255-261 How to Cite?
AbstractSince the clinical success of cisplatin and its derivatives, considerable effort has been expended by academics and pharmacological companies to the development of novel metal-based drugs. DNA is believed to be the main target of cisplatin, and there have been extensive studies on the binding between metal complexes and DNA targets. Recently, new light has been shed on the discovery of metal-based drugs that inhibit enzymatic activities or even target proteins directly. This review highlights some exciting results published recently on the development of platinum, gold, and ruthenium complexes as enzyme inhibitors for potential therapeutic applications. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/168443
ISSN
2015 Impact Factor: 7.643
2015 SCImago Journal Rankings: 3.614
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChe, CMen_US
dc.contributor.authorSiu, FMen_US
dc.date.accessioned2012-10-08T03:18:59Z-
dc.date.available2012-10-08T03:18:59Z-
dc.date.issued2010en_US
dc.identifier.citationCurrent Opinion In Chemical Biology, 2010, v. 14 n. 2, p. 255-261en_US
dc.identifier.issn1367-5931en_US
dc.identifier.urihttp://hdl.handle.net/10722/168443-
dc.description.abstractSince the clinical success of cisplatin and its derivatives, considerable effort has been expended by academics and pharmacological companies to the development of novel metal-based drugs. DNA is believed to be the main target of cisplatin, and there have been extensive studies on the binding between metal complexes and DNA targets. Recently, new light has been shed on the discovery of metal-based drugs that inhibit enzymatic activities or even target proteins directly. This review highlights some exciting results published recently on the development of platinum, gold, and ruthenium complexes as enzyme inhibitors for potential therapeutic applications. © 2009 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/cbien_US
dc.relation.ispartofCurrent Opinion in Chemical Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoordination Complexes - Pharmacology - Therapeutic Useen_US
dc.subject.meshEnzyme Inhibitors - Pharmacology - Therapeutic Useen_US
dc.subject.meshGold Compounds - Pharmacology - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshPlatinum Compounds - Pharmacology - Therapeutic Useen_US
dc.subject.meshRuthenium Compounds - Pharmacology - Therapeutic Useen_US
dc.titleMetal complexes in medicine with a focus on enzyme inhibitionen_US
dc.typeArticleen_US
dc.identifier.emailChe, CM:cmche@hku.hken_US
dc.identifier.emailSiu, FM:fmsiu@hku.hken_US
dc.identifier.authorityChe, CM=rp00670en_US
dc.identifier.authoritySiu, FM=rp00776en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cbpa.2009.11.015en_US
dc.identifier.pmid20018553-
dc.identifier.scopuseid_2-s2.0-77949889854en_US
dc.identifier.hkuros171403-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949889854&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue2en_US
dc.identifier.spage255en_US
dc.identifier.epage261en_US
dc.identifier.isiWOS:000277110800019-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChe, CM=7102442791en_US
dc.identifier.scopusauthoridSiu, FM=6701518489en_US
dc.identifier.citeulike6407000-

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